Regulatory effect of anti-gp130 functional mAb on IL-6 mediated RANKL and Wnt5a expression through JAK-STAT3 signaling pathway in FLS

We investigated the effect on rheumatoid arthritis (RA) of an anti-gp130 monoclonal antibody (mAb) and its mechanism using RA fibroblast-like synoviocytes (FLS) and a collagen antibody–induced arthritis (CAIA) mouse model. We determined the interleukin 6 (IL-6), IL-6 receptor α (IL-6Rα), gp130, rece...

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Detalles Bibliográficos
Autores principales: Miao, Ping, Zhou, Xiao Wei, Wang, Ping, Zhao, Rong, Chen, Ninan, Hu, Chao Ying, Chen, Xue Hua, Qian, Liu, Yu, Qi Wen, Zhang, Ji Ying, Xu, Rong, He, Dong Yi, Xiao, Lian Bo, Li, Pu, Lu, Mason, Zhang, Dong Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945543/
https://www.ncbi.nlm.nih.gov/pubmed/29755657
http://dx.doi.org/10.18632/oncotarget.23917

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