Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation

Accumulating evidence revealed that mesenchymal stem cells (MSCs) confer cardioprotection against myocardial infarction (MI). However, the poor survival and engraftment rate of the transplanted cells limited their therapeutic efficacy in the heart. The enhanced leptin production associated with hypo...

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Detalles Bibliográficos
Autores principales: Yang, Fan, Wu, Rongrong, Jiang, Zhi, Chen, Jinghai, Nan, Jinliang, Su, Sheng’an, Zhang, Na, Wang, Chen, Zhao, Jing, Ni, Cheng, Wang, Yingchao, Hu, Wangxing, Zeng, Zhiru, Zhu, Keyang, Liu, Xianbao, Hu, Xinyang, Zhu, Wei, Yu, Hong, Huang, Jinyu, Wang, Jian’an
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945599/
https://www.ncbi.nlm.nih.gov/pubmed/29748581
http://dx.doi.org/10.1038/s41419-018-0579-9

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