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Altered attentional control over the salience network in complex regional pain syndrome

The degree and salience of pain have been known to be constantly monitored and modulated by the brain. In the case of maladaptive neural responses as reported in centralized pain conditions such as complex regional pain syndrome (CRPS), the perception of pain is amplified and remains elevated even w...

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Autores principales: Kim, Jungyoon, Kang, Ilhyang, Chung, Yong-An, Kim, Tae-Suk, Namgung, Eun, Lee, Suji, Oh, Jin Kyoung, Jeong, Hyeonseok S., Cho, Hanbyul, Kim, Myeong Ju, Kim, Tammy D., Choi, Soo Hyun, Lim, Soo Mee, Lyoo, In Kyoon, Yoon, Sujung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945627/
https://www.ncbi.nlm.nih.gov/pubmed/29748588
http://dx.doi.org/10.1038/s41598-018-25757-2
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author Kim, Jungyoon
Kang, Ilhyang
Chung, Yong-An
Kim, Tae-Suk
Namgung, Eun
Lee, Suji
Oh, Jin Kyoung
Jeong, Hyeonseok S.
Cho, Hanbyul
Kim, Myeong Ju
Kim, Tammy D.
Choi, Soo Hyun
Lim, Soo Mee
Lyoo, In Kyoon
Yoon, Sujung
author_facet Kim, Jungyoon
Kang, Ilhyang
Chung, Yong-An
Kim, Tae-Suk
Namgung, Eun
Lee, Suji
Oh, Jin Kyoung
Jeong, Hyeonseok S.
Cho, Hanbyul
Kim, Myeong Ju
Kim, Tammy D.
Choi, Soo Hyun
Lim, Soo Mee
Lyoo, In Kyoon
Yoon, Sujung
author_sort Kim, Jungyoon
collection PubMed
description The degree and salience of pain have been known to be constantly monitored and modulated by the brain. In the case of maladaptive neural responses as reported in centralized pain conditions such as complex regional pain syndrome (CRPS), the perception of pain is amplified and remains elevated even without sustained peripheral pain inputs. Given that the attentional state of the brain greatly influences the perception and interpretation of pain, we investigated the role of the attention network and its dynamic interactions with other pain-related networks of the brain in CRPS. We examined alterations in the intra- and inter-network functional connectivities in 21 individuals with CRPS and 49 controls. CRPS-related reduction in intra-network functional connectivity was found in the attention network. Individuals with CRPS had greater inter-network connectivities between the attention and salience networks as compared with healthy controls. Furthermore, individuals within the CRPS group with high levels of pain catastrophizing showed greater inter-network connectivities between the attention and salience networks. Taken together, the current findings suggest that these altered connectivities may be potentially associated with the maladaptive pain coping as found in CRPS patients.
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spelling pubmed-59456272018-05-14 Altered attentional control over the salience network in complex regional pain syndrome Kim, Jungyoon Kang, Ilhyang Chung, Yong-An Kim, Tae-Suk Namgung, Eun Lee, Suji Oh, Jin Kyoung Jeong, Hyeonseok S. Cho, Hanbyul Kim, Myeong Ju Kim, Tammy D. Choi, Soo Hyun Lim, Soo Mee Lyoo, In Kyoon Yoon, Sujung Sci Rep Article The degree and salience of pain have been known to be constantly monitored and modulated by the brain. In the case of maladaptive neural responses as reported in centralized pain conditions such as complex regional pain syndrome (CRPS), the perception of pain is amplified and remains elevated even without sustained peripheral pain inputs. Given that the attentional state of the brain greatly influences the perception and interpretation of pain, we investigated the role of the attention network and its dynamic interactions with other pain-related networks of the brain in CRPS. We examined alterations in the intra- and inter-network functional connectivities in 21 individuals with CRPS and 49 controls. CRPS-related reduction in intra-network functional connectivity was found in the attention network. Individuals with CRPS had greater inter-network connectivities between the attention and salience networks as compared with healthy controls. Furthermore, individuals within the CRPS group with high levels of pain catastrophizing showed greater inter-network connectivities between the attention and salience networks. Taken together, the current findings suggest that these altered connectivities may be potentially associated with the maladaptive pain coping as found in CRPS patients. Nature Publishing Group UK 2018-05-10 /pmc/articles/PMC5945627/ /pubmed/29748588 http://dx.doi.org/10.1038/s41598-018-25757-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kim, Jungyoon
Kang, Ilhyang
Chung, Yong-An
Kim, Tae-Suk
Namgung, Eun
Lee, Suji
Oh, Jin Kyoung
Jeong, Hyeonseok S.
Cho, Hanbyul
Kim, Myeong Ju
Kim, Tammy D.
Choi, Soo Hyun
Lim, Soo Mee
Lyoo, In Kyoon
Yoon, Sujung
Altered attentional control over the salience network in complex regional pain syndrome
title Altered attentional control over the salience network in complex regional pain syndrome
title_full Altered attentional control over the salience network in complex regional pain syndrome
title_fullStr Altered attentional control over the salience network in complex regional pain syndrome
title_full_unstemmed Altered attentional control over the salience network in complex regional pain syndrome
title_short Altered attentional control over the salience network in complex regional pain syndrome
title_sort altered attentional control over the salience network in complex regional pain syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945627/
https://www.ncbi.nlm.nih.gov/pubmed/29748588
http://dx.doi.org/10.1038/s41598-018-25757-2
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