Cargando…

Gene-by-environment interactions that disrupt mitochondrial homeostasis cause neurodegeneration in C. elegans Parkinson’s models

Parkinson’s disease (PD) is a complex multifactorial disorder where environmental factors interact with genetic susceptibility. Accumulating evidence suggests that mitochondria have a central role in the progression of neurodegeneration in sporadic and/or genetic forms of PD. We previously reported...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Hanna, Perentis, Rylee J., Caldwell, Guy A., Caldwell, Kim A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945629/ https://www.ncbi.nlm.nih.gov/pubmed/29748634 http://dx.doi.org/10.1038/s41419-018-0619-5

Ejemplares similares

Modeling neurodegeneration in Caenorhabditis elegans
por: Caldwell, Kim A., et al.
Publicado: (2020)

An Environmental Contributor to Parkinson’s Disease Causes a Hormetic Lifespan Effect in C. elegans
por: Thies, Jennifer, et al.
Publicado: (2021)

An Environmental Contributor to Parkinson’s Disease Causes a Hormetic Lifespan Effect in C. elegans
por: Thies, Jennifer, et al.
Publicado: (2021)

Mitochondrial dysfunction, oxidative stress, and neurodegeneration elicited by a bacterial metabolite in a C. elegans Parkinson's model
por: Ray, A, et al.
Publicado: (2014)

Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration
por: Hartman, Jessica H., et al.
Publicado: (2019)

Functional Modulators of Resilience to Age-Associated Dopaminergic Neurodegeneration in C. elegans
por: Caldwell, Guy
Publicado: (2020)

Found in Translation: The Utility of C. elegans Alpha-Synuclein Models of Parkinson’s Disease
por: Gaeta, Anthony L., et al.
Publicado: (2019)

Mechanistic impacts of bacterial diet on dopaminergic neurodegeneration in a Caenorhabditis elegans α-synuclein model of Parkinson’s disease
por: Gaeta, Anthony L., et al.
Publicado: (2023)

Attenuation of Dopaminergic Neurodegeneration in a C. elegans Parkinson’s Model through Regulation of Xanthine Dehydrogenase (XDH-1) Expression by the RNA Editase, ADR-2
por: Starr, Lindsey A., et al.
Publicado: (2023)

Xanthine Dehydrogenase Is a Modulator of Dopaminergic Neurodegeneration in Response to Bacterial Metabolite Exposure in C. elegans
por: Thies, Jennifer L., et al.
Publicado: (2023)

No Country for Old Worms: A Systematic Review of the Application of C. elegans to Investigate a Bacterial Source of Environmental Neurotoxicity in Parkinson’s Disease
por: Caldwell, Kim A., et al.
Publicado: (2018)

Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans
por: Gaeta, Anthony L., et al.
Publicado: (2022)

ApoE-associated modulation of neuroprotection from Aβ-mediated neurodegeneration in transgenic Caenorhabditis elegans
por: Griffin, Edward F., et al.
Publicado: (2019)

Presenilin mutations deregulate mitochondrial Ca(2+) homeostasis and metabolic activity causing neurodegeneration in Caenorhabditis elegans
por: Sarasija, Shaarika, et al.
Publicado: (2018)

Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production
por: Cvetko, Filip, et al.
Publicado: (2020)

Enhanced pentylenetetrazole sensitivity in a C. elegans mutant associated with DNM1 encephalopathy
por: Vaji, Madeline A., et al.
Publicado: (2020)

Phenotypic modulation of pentylenetetrazole-induced convulsive behaviors in C. elegans carrying a mutation associated with Alzheimer’s disease
por: Vaji, Madeline A., et al.
Publicado: (2020)

Prohibitins in neurodegeneration and mitochondrial homeostasis
por: Fernandez-Abascal, Jesus, et al.
Publicado: (2022)

TorsinA rescues ER-associated stress and locomotive defects in C. elegans models of ALS
por: Thompson, Michelle L., et al.
Publicado: (2014)

Back to the future through the wormhole: Caenorhabditis elegans as a preclinical model
por: Caldwell, Guy A.
Publicado: (2023)

Chemical Compensation of Mitochondrial Phospholipid Depletion in Yeast and Animal Models of Parkinson’s Disease
por: Wang, Shaoxiao, et al.
Publicado: (2016)

Disruption of Mitochondrial Homeostasis: The Role of PINK1 in Parkinson’s Disease
por: Vizziello, Maria, et al.
Publicado: (2021)

The Crosstalk between Microbiome and Mitochondrial Homeostasis in Neurodegeneration
por: Borbolis, Fivos, et al.
Publicado: (2023)

Exposure to Mitochondrial Genotoxins and Dopaminergic Neurodegeneration in Caenorhabditis elegans
por: González-Hunt, Claudia P., et al.
Publicado: (2014)

Lipase regulation of cellular fatty acid homeostasis as a Parkinson’s disease therapeutic strategy
por: Fanning, Saranna, et al.
Publicado: (2022)

A mechanosensory defect in a C. elegans amyloid-beta glutamatergic neuron model is reversed following exposure to Salvia species extracts
por: Schlein, Melissa L, et al.
Publicado: (2023)

m-AAA proteases, mitochondrial calcium homeostasis and neurodegeneration
por: Patron, Maria, et al.
Publicado: (2018)

Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson’s disease
por: Nim, Satra, et al.
Publicado: (2023)

Mitochondrial Uncoupling Attenuates Age-Dependent Neurodegeneration in C. elegans
por: Cho, Injeong, et al.
Publicado: (2017)

Role of Presenilin in Mitochondrial Oxidative Stress and Neurodegeneration in Caenorhabditis elegans
por: Sarasija, Shaarika, et al.
Publicado: (2018)

Flavonoids mitigate neurodegeneration in aged Caenorhabditis elegans by mitochondrial uncoupling
por: Cho, Injeong, et al.
Publicado: (2020)

Mutant TDP-43 and FUS Cause Age-Dependent Paralysis and Neurodegeneration in C. elegans
por: Vaccaro, Alexandra, et al.
Publicado: (2012)

Impaired mitochondrial homeostasis and neurodegeneration: towards new therapeutic targets?
por: Corona, Juan Carlos, et al.
Publicado: (2014)

A bacterial metabolite induces glutathione-tractable proteostatic damage, proteasomal disturbances, and PINK1-dependent autophagy in C. elegans
por: Martinez, B A, et al.
Publicado: (2015)

Oxidative Stress Mechanisms Underlying Parkinson’s Disease-Associated Neurodegeneration in C. elegans
por: Chakraborty, Sudipta, et al.
Publicado: (2013)

Brain Mitochondrial Dysfunction in Aging, Neurodegeneration, and Parkinson's Disease
por: Navarro, Ana, et al.
Publicado: (2010)

Investigating Bacterial Sources of Toxicity as an Environmental Contributor to Dopaminergic Neurodegeneration
por: Caldwell, Kim A., et al.
Publicado: (2009)

Disrupted glycosylation of lipids and proteins is a cause of neurodegeneration
por: Moll, Tobias, et al.
Publicado: (2020)

Parkinson’s disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes
por: Wang, Wenzhang, et al.
Publicado: (2015)

Necrotic Neurodegeneration in Caenorhabditis Elegans
por: Xu, Keli, et al.
Publicado: (2001)

Cannot write session to /tmp/vufind_sessions/sess_ip7b6rnqlhcdp7h7dvmt164snl