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The thioredoxin-1 system is essential for fueling DNA synthesis during T-cell metabolic reprogramming and proliferation

The thioredoxin-1 (Trx1) system is an important contributor to cellular redox balance and is a sensor of energy and glucose metabolism. Here we show critical c-Myc-dependent activation of the Trx1 system during thymocyte and peripheral T-cell proliferation, but repression during T-cell quiescence. D...

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Detalles Bibliográficos
Autores principales:	Muri, Jonathan, Heer, Sebastian, Matsushita, Mai, Pohlmeier, Lea, Tortola, Luigi, Fuhrer, Tobias, Conrad, Marcus, Zamboni, Nicola, Kisielow, Jan, Kopf, Manfred
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945637/ https://www.ncbi.nlm.nih.gov/pubmed/29749372 http://dx.doi.org/10.1038/s41467-018-04274-w

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