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Clinically relevant mutations in the ABCG2 transporter uncovered by genetic analysis linked to erythrocyte membrane protein expression

The ABCG2 membrane protein is a key xeno- and endobiotic transporter, modulating the absorption and metabolism of pharmacological agents and causing multidrug resistance in cancer. ABCG2 is also involved in uric acid elimination and its impaired function is causative in gout. Analysis of ABCG2 expre...

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Detalles Bibliográficos
Autores principales:	Zámbó, Boglárka, Bartos, Zsuzsa, Mózner, Orsolya, Szabó, Edit, Várady, György, Poór, Gyula, Pálinkás, Márton, Andrikovics, Hajnalka, Hegedűs, Tamás, Homolya, László, Sarkadi, Balázs
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945641/ https://www.ncbi.nlm.nih.gov/pubmed/29749379 http://dx.doi.org/10.1038/s41598-018-25695-z

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