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Semaphorin 4D correlates with increased bone resorption, hypercalcemia, and disease stage in newly diagnosed patients with multiple myeloma

Multiple myeloma (MM) is characterized by bone destruction due to increased bone resorption and decreased bone formation. Semaphorin 4D (CD100, Sema4D) is expressed by osteoclasts, binds to its receptor Plexin-B1, and acts as a mediator of osteoclast–osteoblast interaction that ultimately inhibits o...

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Detalles Bibliográficos
Autores principales:	Terpos, Evangelos, Ntanasis-Stathopoulos, Ioannis, Christoulas, Dimitrios, Bagratuni, Tina, Bakogeorgos, Marios, Gavriatopoulou, Maria, Eleutherakis-Papaiakovou, Evangelos, Kanellias, Nikolaos, Kastritis, Efstathios, Dimopoulos, Meletios A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945651/ https://www.ncbi.nlm.nih.gov/pubmed/29748532 http://dx.doi.org/10.1038/s41408-018-0075-6

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