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The role of complement components C1q, MBL and C1 inhibitor in pathogenesis of endometriosis
PURPOSE: The purpose of the work was to evaluate possible associations between the complement components C1q, mannose-binding lectin (MBL) and C1 inhibitor (C1INH) with pathogenesis of endometriosis. METHODS: Concentrations of C1q, MBL and C1INH were measured by ELISA in peritoneal fluid (PF) in 80...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945730/ https://www.ncbi.nlm.nih.gov/pubmed/29572748 http://dx.doi.org/10.1007/s00404-018-4754-0 |
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author | Sikora, Justyna Wróblewska-Czech, Agnieszka Smycz-Kubańska, Marta Mielczarek-Palacz, Aleksandra Cygal, Anna Witek, Andrzej Kondera-Anasz, Zdzisława |
author_facet | Sikora, Justyna Wróblewska-Czech, Agnieszka Smycz-Kubańska, Marta Mielczarek-Palacz, Aleksandra Cygal, Anna Witek, Andrzej Kondera-Anasz, Zdzisława |
author_sort | Sikora, Justyna |
collection | PubMed |
description | PURPOSE: The purpose of the work was to evaluate possible associations between the complement components C1q, mannose-binding lectin (MBL) and C1 inhibitor (C1INH) with pathogenesis of endometriosis. METHODS: Concentrations of C1q, MBL and C1INH were measured by ELISA in peritoneal fluid (PF) in 80 women with or without endometriosis. RESULTS: Significantly higher PF levels of C1q, MBL and C1INH in women with endometriosis compared to control group were observed (p < 0.0001). A higher concentration of the studied parameter was found in PF of women at the early stage of the disease, as compared to women with advanced endometriosis (p < 0.0001). CONCLUSIONS: Our research suggests that in the peritoneal cavity in women with endometriosis there are abnormal regulations of both the classical and lectin pathways of the complement system. This can suggest impairments in purification of peritoneal cavity from ectopic endometrial cells and augmented local inflammation in endometriosis patients. |
format | Online Article Text |
id | pubmed-5945730 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer Berlin Heidelberg |
record_format | MEDLINE/PubMed |
spelling | pubmed-59457302018-05-15 The role of complement components C1q, MBL and C1 inhibitor in pathogenesis of endometriosis Sikora, Justyna Wróblewska-Czech, Agnieszka Smycz-Kubańska, Marta Mielczarek-Palacz, Aleksandra Cygal, Anna Witek, Andrzej Kondera-Anasz, Zdzisława Arch Gynecol Obstet General Gynecology PURPOSE: The purpose of the work was to evaluate possible associations between the complement components C1q, mannose-binding lectin (MBL) and C1 inhibitor (C1INH) with pathogenesis of endometriosis. METHODS: Concentrations of C1q, MBL and C1INH were measured by ELISA in peritoneal fluid (PF) in 80 women with or without endometriosis. RESULTS: Significantly higher PF levels of C1q, MBL and C1INH in women with endometriosis compared to control group were observed (p < 0.0001). A higher concentration of the studied parameter was found in PF of women at the early stage of the disease, as compared to women with advanced endometriosis (p < 0.0001). CONCLUSIONS: Our research suggests that in the peritoneal cavity in women with endometriosis there are abnormal regulations of both the classical and lectin pathways of the complement system. This can suggest impairments in purification of peritoneal cavity from ectopic endometrial cells and augmented local inflammation in endometriosis patients. Springer Berlin Heidelberg 2018-03-23 2018 /pmc/articles/PMC5945730/ /pubmed/29572748 http://dx.doi.org/10.1007/s00404-018-4754-0 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | General Gynecology Sikora, Justyna Wróblewska-Czech, Agnieszka Smycz-Kubańska, Marta Mielczarek-Palacz, Aleksandra Cygal, Anna Witek, Andrzej Kondera-Anasz, Zdzisława The role of complement components C1q, MBL and C1 inhibitor in pathogenesis of endometriosis |
title | The role of complement components C1q, MBL and C1 inhibitor in pathogenesis of endometriosis |
title_full | The role of complement components C1q, MBL and C1 inhibitor in pathogenesis of endometriosis |
title_fullStr | The role of complement components C1q, MBL and C1 inhibitor in pathogenesis of endometriosis |
title_full_unstemmed | The role of complement components C1q, MBL and C1 inhibitor in pathogenesis of endometriosis |
title_short | The role of complement components C1q, MBL and C1 inhibitor in pathogenesis of endometriosis |
title_sort | role of complement components c1q, mbl and c1 inhibitor in pathogenesis of endometriosis |
topic | General Gynecology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945730/ https://www.ncbi.nlm.nih.gov/pubmed/29572748 http://dx.doi.org/10.1007/s00404-018-4754-0 |
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