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Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis

Hemoglobinuria is associated with kidney injury in various hemolytic pathologies. Currently, there is no treatment available and its pathophysiology is not completely understood. Here we studied the potential detrimental effects of hemoglobin (Hb) exposure to the distal nephron (DN). Involvement of...

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Detalles Bibliográficos
Autores principales:	van Swelm, Rachel P. L., Vos, Madelon, Verhoeven, Frank, Thévenod, Frank, Swinkels, Dorine W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945780/ https://www.ncbi.nlm.nih.gov/pubmed/29749404 http://dx.doi.org/10.1038/s41419-018-0568-z

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