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Direct neurotransmitter activation of voltage-gated potassium channels

Voltage-gated potassium channels KCNQ2–5 generate the M-current, which controls neuronal excitability. KCNQ2–5 subunits each harbor a high-affinity anticonvulsant drug-binding pocket containing an essential tryptophan (W265 in human KCNQ3) conserved for >500 million years, yet lacking a known phy...

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Detalles Bibliográficos
Autores principales:	Manville, Rían W., Papanikolaou, Maria, Abbott, Geoffrey W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945843/ https://www.ncbi.nlm.nih.gov/pubmed/29748663 http://dx.doi.org/10.1038/s41467-018-04266-w

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