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CRISPR-LbCpf1 prevents choroidal neovascularization in a mouse model of age-related macular degeneration

LbCpf1, derived from Lachnospiraceae bacterium ND2006, is a CRISPR RNA-guided endonuclease and holds promise for therapeutic applications. Here we show that LbCpf1 can be used for therapeutic gene editing in a mouse model of age-related macular degeneration (AMD). The intravitreal delivery of LbCpf1...

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Detalles Bibliográficos
Autores principales:	Koo, Taeyoung, Park, Sung Wook, Jo, Dong Hyun, Kim, Daesik, Kim, Jin Hyoung, Cho, Hee-Yeon, Kim, Jeungeun, Kim, Jeong Hun, Kim, Jin-Soo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945874/ https://www.ncbi.nlm.nih.gov/pubmed/29748595 http://dx.doi.org/10.1038/s41467-018-04175-y

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