Cargando…

Leg Movement Activity During Sleep in Adults With Attention-Deficit/Hyperactivity Disorder

Objectives: To conduct a first detailed analysis of the pattern of leg movement (LM) activity during sleep in adult subjects with Attention-Deficit/Hyperactivity Disorder (ADHD) compared to healthy controls. Methods: Fifteen ADHD patients and 18 control subjects underwent an in-lab polysomnographic...

Descripción completa

Detalles Bibliográficos
Autores principales: Garbazza, Corrado, Sauter, Cornelia, Paul, Juliane, Kollek, Jenny, Dujardin, Catharine, Hackethal, Sandra, Dorn, Hans, Peter, Anita, Hansen, Marie-Luise, Manconi, Mauro, Ferri, Raffaele, Danker-Hopfe, Heidi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945883/
https://www.ncbi.nlm.nih.gov/pubmed/29780335
http://dx.doi.org/10.3389/fpsyt.2018.00179
_version_ 1783322079637012480
author Garbazza, Corrado
Sauter, Cornelia
Paul, Juliane
Kollek, Jenny
Dujardin, Catharine
Hackethal, Sandra
Dorn, Hans
Peter, Anita
Hansen, Marie-Luise
Manconi, Mauro
Ferri, Raffaele
Danker-Hopfe, Heidi
author_facet Garbazza, Corrado
Sauter, Cornelia
Paul, Juliane
Kollek, Jenny
Dujardin, Catharine
Hackethal, Sandra
Dorn, Hans
Peter, Anita
Hansen, Marie-Luise
Manconi, Mauro
Ferri, Raffaele
Danker-Hopfe, Heidi
author_sort Garbazza, Corrado
collection PubMed
description Objectives: To conduct a first detailed analysis of the pattern of leg movement (LM) activity during sleep in adult subjects with Attention-Deficit/Hyperactivity Disorder (ADHD) compared to healthy controls. Methods: Fifteen ADHD patients and 18 control subjects underwent an in-lab polysomnographic sleep study. The periodic character of LMs was evaluated with established markers of “periodicity,” i.e., the periodicity index, intermovement intervals, and time distribution of LM during sleep, in addition to standard parameters such as the periodic leg movement during sleep index (PLMSI) and the periodic leg movement during sleep arousal index (PLMSAI). Subjective sleep and psychiatric symptoms were assessed using several, self-administered, screening questionnaires. Results: Objective sleep parameters from the baseline night did not significantly differ between ADHD and control subjects, except for a longer sleep latency (SL), a longer duration of the periodic leg movements during sleep (PLMS) in REM sleep and a higher PLMSI also in REM sleep. Data from the sleep questionnaires showed perception of poor sleep quality in ADHD patients. Conclusions: Leg movements during sleep in ADHD adults are not significantly more frequent than in healthy controls and the nocturnal motor events do not show an increased periodicity in these patients. The non-periodic character of LMs in ADHD has already been shown in children and seems to differentiate ADHD from other pathophysiological related conditions like restless legs syndrome (RLS) or periodic limb movement disorder (PLMD). The reduced subjective sleep quality reported by ADHD adults contrasted with the normal objective polysomnographic parameters, which could suggest a sleep-state misperception in these individuals or more subtle sleep abnormalities not picked up by the traditional sleep staging.
format Online
Article
Text
id pubmed-5945883
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-59458832018-05-18 Leg Movement Activity During Sleep in Adults With Attention-Deficit/Hyperactivity Disorder Garbazza, Corrado Sauter, Cornelia Paul, Juliane Kollek, Jenny Dujardin, Catharine Hackethal, Sandra Dorn, Hans Peter, Anita Hansen, Marie-Luise Manconi, Mauro Ferri, Raffaele Danker-Hopfe, Heidi Front Psychiatry Psychiatry Objectives: To conduct a first detailed analysis of the pattern of leg movement (LM) activity during sleep in adult subjects with Attention-Deficit/Hyperactivity Disorder (ADHD) compared to healthy controls. Methods: Fifteen ADHD patients and 18 control subjects underwent an in-lab polysomnographic sleep study. The periodic character of LMs was evaluated with established markers of “periodicity,” i.e., the periodicity index, intermovement intervals, and time distribution of LM during sleep, in addition to standard parameters such as the periodic leg movement during sleep index (PLMSI) and the periodic leg movement during sleep arousal index (PLMSAI). Subjective sleep and psychiatric symptoms were assessed using several, self-administered, screening questionnaires. Results: Objective sleep parameters from the baseline night did not significantly differ between ADHD and control subjects, except for a longer sleep latency (SL), a longer duration of the periodic leg movements during sleep (PLMS) in REM sleep and a higher PLMSI also in REM sleep. Data from the sleep questionnaires showed perception of poor sleep quality in ADHD patients. Conclusions: Leg movements during sleep in ADHD adults are not significantly more frequent than in healthy controls and the nocturnal motor events do not show an increased periodicity in these patients. The non-periodic character of LMs in ADHD has already been shown in children and seems to differentiate ADHD from other pathophysiological related conditions like restless legs syndrome (RLS) or periodic limb movement disorder (PLMD). The reduced subjective sleep quality reported by ADHD adults contrasted with the normal objective polysomnographic parameters, which could suggest a sleep-state misperception in these individuals or more subtle sleep abnormalities not picked up by the traditional sleep staging. Frontiers Media S.A. 2018-05-04 /pmc/articles/PMC5945883/ /pubmed/29780335 http://dx.doi.org/10.3389/fpsyt.2018.00179 Text en Copyright © 2018 Garbazza, Sauter, Paul, Kollek, Dujardin, Hackethal, Dorn, Peter, Hansen, Manconi, Ferri and Danker-Hopfe. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychiatry
Garbazza, Corrado
Sauter, Cornelia
Paul, Juliane
Kollek, Jenny
Dujardin, Catharine
Hackethal, Sandra
Dorn, Hans
Peter, Anita
Hansen, Marie-Luise
Manconi, Mauro
Ferri, Raffaele
Danker-Hopfe, Heidi
Leg Movement Activity During Sleep in Adults With Attention-Deficit/Hyperactivity Disorder
title Leg Movement Activity During Sleep in Adults With Attention-Deficit/Hyperactivity Disorder
title_full Leg Movement Activity During Sleep in Adults With Attention-Deficit/Hyperactivity Disorder
title_fullStr Leg Movement Activity During Sleep in Adults With Attention-Deficit/Hyperactivity Disorder
title_full_unstemmed Leg Movement Activity During Sleep in Adults With Attention-Deficit/Hyperactivity Disorder
title_short Leg Movement Activity During Sleep in Adults With Attention-Deficit/Hyperactivity Disorder
title_sort leg movement activity during sleep in adults with attention-deficit/hyperactivity disorder
topic Psychiatry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945883/
https://www.ncbi.nlm.nih.gov/pubmed/29780335
http://dx.doi.org/10.3389/fpsyt.2018.00179
work_keys_str_mv AT garbazzacorrado legmovementactivityduringsleepinadultswithattentiondeficithyperactivitydisorder
AT sautercornelia legmovementactivityduringsleepinadultswithattentiondeficithyperactivitydisorder
AT pauljuliane legmovementactivityduringsleepinadultswithattentiondeficithyperactivitydisorder
AT kollekjenny legmovementactivityduringsleepinadultswithattentiondeficithyperactivitydisorder
AT dujardincatharine legmovementactivityduringsleepinadultswithattentiondeficithyperactivitydisorder
AT hackethalsandra legmovementactivityduringsleepinadultswithattentiondeficithyperactivitydisorder
AT dornhans legmovementactivityduringsleepinadultswithattentiondeficithyperactivitydisorder
AT peteranita legmovementactivityduringsleepinadultswithattentiondeficithyperactivitydisorder
AT hansenmarieluise legmovementactivityduringsleepinadultswithattentiondeficithyperactivitydisorder
AT manconimauro legmovementactivityduringsleepinadultswithattentiondeficithyperactivitydisorder
AT ferriraffaele legmovementactivityduringsleepinadultswithattentiondeficithyperactivitydisorder
AT dankerhopfeheidi legmovementactivityduringsleepinadultswithattentiondeficithyperactivitydisorder