Cargando…

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity

Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, non-coding variants from which pinpointing causal genes remains challenging. Here, we combined data from 718,7...

Descripción completa

Detalles Bibliográficos
Autores principales:	Turcot, Valérie, Lu, Yingchang, Highland, Heather M, Schurmann, Claudia, Justice, Anne E, Fine, Rebecca S, Bradfield, Jonathan P, Esko, Tõnu, Giri, Ayush, Graff, Mariaelisa, Guo, Xiuqing, Hendricks, Audrey E, Karaderi, Tugce, Lempradl, Adelheid, Locke, Adam E, Mahajan, Anubha, Marouli, Eirini, Sivapalaratnam, Suthesh, Young, Kristin L, Alfred, Tamuno, Feitosa, Mary F, Masca, Nicholas GD, Manning, Alisa K, Medina-Gomez, Carolina, Mudgal, Poorva, Ng, Maggie CY, Reiner, Alex P, Vedantam, Sailaja, Willems, Sara M, Winkler, Thomas W, Abecasis, Goncalo, Aben, Katja K, Alam, Dewan S, Alharthi, Sameer E, Allison, Matthew, Amouyel, Philippe, Asselbergs, Folkert W, Auer, Paul L, Balkau, Beverley, Bang, Lia E, Barroso, Inês, Bastarache, Lisa, Benn, Marianne, Bergmann, Sven, Bielak, Lawrence F, Blüher, Matthias, Boehnke, Michael, Boeing, Heiner, Boerwinkle, Eric, Böger, Carsten A, Bork-Jensen, Jette, Bots, Michiel L, Bottinger, Erwin P, Bowden, Donald W, Brandslund, Ivan, Breen, Gerome, Brilliant, Murray H, Broer, Linda, Brumat, Marco, Burt, Amber A, Butterworth, Adam S, Campbell, Peter T, Cappellani, Stefania, Carey, David J, Catamo, Eulalia, Caulfield, Mark J, Chambers, John C, Chasman, Daniel I, Chen, Yii-Der Ida, Chowdhury, Rajiv, Christensen, Cramer, Chu, Audrey Y, Cocca, Massimiliano, Collins, Francis S, Cook, James P, Corley, Janie, Galbany, Jordi Corominas, Cox, Amanda J, Crosslin, David S, Cuellar-Partida, Gabriel, D'Eustacchio, Angela, Danesh, John, Davies, Gail, de Bakker, Paul IW, de Groot, Mark CH, de Mutsert, Renée, Deary, Ian J, Dedoussis, George, Demerath, Ellen W, den Heijer, Martin, den Hollander, Anneke I, den Ruijter, Hester M, Dennis, Joe G, Denny, Josh C, Di Angelantonio, Emanuele, Drenos, Fotios, Du, Mengmeng, Dubé, Marie-Pierre, Dunning, Alison M, Easton, Douglas F, Edwards, Todd L, Ellinghaus, David, Ellinor, Patrick T, Elliott, Paul, Evangelou, Evangelos, Farmaki, Aliki-Eleni, Farooqi, I. Sadaf, Faul, Jessica D, Fauser, Sascha, Feng, Shuang, Ferrannini, Ele, Ferrieres, Jean, Florez, Jose C, Ford, Ian, Fornage, Myriam, Franco, Oscar H, Franke, Andre, Franks, Paul W, Friedrich, Nele, Frikke-Schmidt, Ruth, Galesloot, Tessel E., Gan, Wei, Gandin, Ilaria, Gasparini, Paolo, Gibson, Jane, Giedraitis, Vilmantas, Gjesing, Anette P, Gordon-Larsen, Penny, Gorski, Mathias, Grabe, Hans-Jörgen, Grant, Struan FA, Grarup, Niels, Griffiths, Helen L, Grove, Megan L, Gudnason, Vilmundur, Gustafsson, Stefan, Haessler, Jeff, Hakonarson, Hakon, Hammerschlag, Anke R, Hansen, Torben, Harris, Kathleen Mullan, Harris, Tamara B, Hattersley, Andrew T, Have, Christian T, Hayward, Caroline, He, Liang, Heard-Costa, Nancy L, Heath, Andrew C, Heid, Iris M, Helgeland, Øyvind, Hernesniemi, Jussi, Hewitt, Alex W, Holmen, Oddgeir L, Hovingh, G Kees, Howson, Joanna MM, Hu, Yao, Huang, Paul L, Huffman, Jennifer E, Ikram, M Arfan, Ingelsson, Erik, Jackson, Anne U, Jansson, Jan-Håkan, Jarvik, Gail P, Jensen, Gorm B, Jia, Yucheng, Johansson, Stefan, Jørgensen, Marit E, Jørgensen, Torben, Jukema, J Wouter, Kahali, Bratati, Kahn, René S, Kähönen, Mika, Kamstrup, Pia R, Kanoni, Stavroula, Kaprio, Jaakko, Karaleftheri, Maria, Kardia, Sharon LR, Karpe, Fredrik, Kathiresan, Sekar, Kee, Frank, Kiemeney, Lambertus A, Kim, Eric, Kitajima, Hidetoshi, Komulainen, Pirjo, Kooner, Jaspal S, Kooperberg, Charles, Korhonen, Tellervo, Kovacs, Peter, Kuivaniemi, Helena, Kutalik, Zoltán, Kuulasmaa, Kari, Kuusisto, Johanna, Laakso, Markku, Lakka, Timo A, Lamparter, David, Lange, Ethan M, Lange, Leslie A, Langenberg, Claudia, Larson, Eric B, Lee, Nanette R, Lehtimäki, Terho, Lewis, Cora E, Li, Huaixing, Li, Jin, Li-Gao, Ruifang, Lin, Honghuang, Lin, Keng-Hung, Lin, Li-An, Lin, Xu, Lind, Lars, Lindström, Jaana, Linneberg, Allan, Liu, Ching-Ti, Liu, Dajiang J, Liu, Yongmei, Lo, Ken Sin, Lophatananon, Artitaya, Lotery, Andrew J, Loukola, Anu, Luan, Jian'an, Lubitz, Steven A, Lyytikäinen, Leo-Pekka, Männistö, Satu, Marenne, Gaëlle, Mazul, Angela L, McCarthy, Mark I, McKean-Cowdin, Roberta, Medland, Sarah E, Meidtner, Karina, Milani, Lili, Mistry, Vanisha, Mitchell, Paul, Mohlke, Karen L, Moilanen, Leena, Moitry, Marie, Montgomery, Grant W, Mook-Kanamori, Dennis O, Moore, Carmel, Mori, Trevor A, Morris, Andrew D, Morris, Andrew P, Müller-Nurasyid, Martina, Munroe, Patricia B, Nalls, Mike A, Narisu, Narisu, Nelson, Christopher P, Neville, Matt, Nielsen, Sune F, Nikus, Kjell, Njølstad, Pål R, Nordestgaard, Børge G, Nyholt, Dale R, O'Connel, Jeffrey R, O’Donoghue, Michelle L., Olde Loohuis, Loes M, Ophoff, Roel A, Owen, Katharine R, Packard, Chris J, Padmanabhan, Sandosh, Palmer, Colin NA, Palmer, Nicholette D, Pasterkamp, Gerard, Patel, Aniruddh P, Pattie, Alison, Pedersen, Oluf, Peissig, Peggy L, Peloso, Gina M, Pennell, Craig E, Perola, Markus, Perry, James A, Perry, John RB, Pers, Tune H, Person, Thomas N, Peters, Annette, Petersen, Eva RB, Peyser, Patricia A, Pirie, Ailith, Polasek, Ozren, Polderman, Tinca J, Puolijoki, Hannu, Raitakari, Olli T, Rasheed, Asif, Rauramaa, Rainer, Reilly, Dermot F, Renström, Frida, Rheinberger, Myriam, Ridker, Paul M, Rioux, John D, Rivas, Manuel A, Roberts, David J, Robertson, Neil R, Robino, Antonietta, Rolandsson, Olov, Rudan, Igor, Ruth, Katherine S, Saleheen, Danish, Salomaa, Veikko, Samani, Nilesh J, Sapkota, Yadav, Sattar, Naveed, Schoen, Robert E, Schreiner, Pamela J, Schulze, Matthias B, Scott, Robert A, Segura-Lepe, Marcelo P, Shah, Svati H, Sheu, Wayne H-H, Sim, Xueling, Slater, Andrew J, Small, Kerrin S, Smith, Albert Vernon, Southam, Lorraine, Spector, Timothy D, Speliotes, Elizabeth K, Starr, John M, Stefansson, Kari, Steinthorsdottir, Valgerdur, Stirrups, Kathleen E, Strauch, Konstantin, Stringham, Heather M, Stumvoll, Michael, Sun, Liang, Surendran, Praveen, Swift, Amy J, Tada, Hayato, Tansey, Katherine E, Tardif, Jean-Claude, Taylor, Kent D, Teumer, Alexander, Thompson, Deborah J, Thorleifsson, Gudmar, Thorsteinsdottir, Unnur, Thuesen, Betina H, Tönjes, Anke, Tromp, Gerard, Trompet, Stella, Tsafantakis, Emmanouil, Tuomilehto, Jaakko, Tybjaerg-Hansen, Anne, Tyrer, Jonathan P, Uher, Rudolf, Uitterlinden, André G, Uusitupa, Matti, van der Laan, Sander W, van Duijn, Cornelia M, van Leeuwen, Nienke, van Setten, Jessica, Vanhala, Mauno, Varbo, Anette, Varga, Tibor V, Varma, Rohit, Velez Edwards, Digna R, Vermeulen, Sita H, Veronesi, Giovanni, Vestergaard, Henrik, Vitart, Veronique, Vogt, Thomas F, Völker, Uwe, Vuckovic, Dragana, Wagenknecht, Lynne E, Walker, Mark, Wallentin, Lars, Wang, Feijie, Wang, Carol A, Wang, Shuai, Wang, Yiqin, Ware, Erin B, Wareham, Nicholas J, Warren, Helen R, Waterworth, Dawn M, Wessel, Jennifer, White, Harvey D, Willer, Cristen J, Wilson, James G, Witte, Daniel R, Wood, Andrew R, Wu, Ying, Yaghootkar, Hanieh, Yao, Jie, Yao, Pang, Yerges-Armstrong, Laura M, Young, Robin, Zeggini, Eleftheria, Zhan, Xiaowei, Zhang, Weihua, Zhao, Jing Hua, Zhao, Wei, Zhou, Wei, Zondervan, Krina T, Rotter, Jerome I, Pospisilik, John A, Rivadeneira, Fernando, Borecki, Ingrid B, Deloukas, Panos, Frayling, Timothy M, Lettre, Guillaume, North, Kari E, Lindgren, Cecilia M, Hirschhorn, Joel N, Loos, Ruth JF
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945951/ https://www.ncbi.nlm.nih.gov/pubmed/29273807 http://dx.doi.org/10.1038/s41588-017-0011-x

_version_	1783322090838949888
author	Turcot, Valérie Lu, Yingchang Highland, Heather M Schurmann, Claudia Justice, Anne E Fine, Rebecca S Bradfield, Jonathan P Esko, Tõnu Giri, Ayush Graff, Mariaelisa Guo, Xiuqing Hendricks, Audrey E Karaderi, Tugce Lempradl, Adelheid Locke, Adam E Mahajan, Anubha Marouli, Eirini Sivapalaratnam, Suthesh Young, Kristin L Alfred, Tamuno Feitosa, Mary F Masca, Nicholas GD Manning, Alisa K Medina-Gomez, Carolina Mudgal, Poorva Ng, Maggie CY Reiner, Alex P Vedantam, Sailaja Willems, Sara M Winkler, Thomas W Abecasis, Goncalo Aben, Katja K Alam, Dewan S Alharthi, Sameer E Allison, Matthew Amouyel, Philippe Asselbergs, Folkert W Auer, Paul L Balkau, Beverley Bang, Lia E Barroso, Inês Bastarache, Lisa Benn, Marianne Bergmann, Sven Bielak, Lawrence F Blüher, Matthias Boehnke, Michael Boeing, Heiner Boerwinkle, Eric Böger, Carsten A Bork-Jensen, Jette Bots, Michiel L Bottinger, Erwin P Bowden, Donald W Brandslund, Ivan Breen, Gerome Brilliant, Murray H Broer, Linda Brumat, Marco Burt, Amber A Butterworth, Adam S Campbell, Peter T Cappellani, Stefania Carey, David J Catamo, Eulalia Caulfield, Mark J Chambers, John C Chasman, Daniel I Chen, Yii-Der Ida Chowdhury, Rajiv Christensen, Cramer Chu, Audrey Y Cocca, Massimiliano Collins, Francis S Cook, James P Corley, Janie Galbany, Jordi Corominas Cox, Amanda J Crosslin, David S Cuellar-Partida, Gabriel D'Eustacchio, Angela Danesh, John Davies, Gail de Bakker, Paul IW de Groot, Mark CH de Mutsert, Renée Deary, Ian J Dedoussis, George Demerath, Ellen W den Heijer, Martin den Hollander, Anneke I den Ruijter, Hester M Dennis, Joe G Denny, Josh C Di Angelantonio, Emanuele Drenos, Fotios Du, Mengmeng Dubé, Marie-Pierre Dunning, Alison M Easton, Douglas F Edwards, Todd L Ellinghaus, David Ellinor, Patrick T Elliott, Paul Evangelou, Evangelos Farmaki, Aliki-Eleni Farooqi, I. Sadaf Faul, Jessica D Fauser, Sascha Feng, Shuang Ferrannini, Ele Ferrieres, Jean Florez, Jose C Ford, Ian Fornage, Myriam Franco, Oscar H Franke, Andre Franks, Paul W Friedrich, Nele Frikke-Schmidt, Ruth Galesloot, Tessel E. Gan, Wei Gandin, Ilaria Gasparini, Paolo Gibson, Jane Giedraitis, Vilmantas Gjesing, Anette P Gordon-Larsen, Penny Gorski, Mathias Grabe, Hans-Jörgen Grant, Struan FA Grarup, Niels Griffiths, Helen L Grove, Megan L Gudnason, Vilmundur Gustafsson, Stefan Haessler, Jeff Hakonarson, Hakon Hammerschlag, Anke R Hansen, Torben Harris, Kathleen Mullan Harris, Tamara B Hattersley, Andrew T Have, Christian T Hayward, Caroline He, Liang Heard-Costa, Nancy L Heath, Andrew C Heid, Iris M Helgeland, Øyvind Hernesniemi, Jussi Hewitt, Alex W Holmen, Oddgeir L Hovingh, G Kees Howson, Joanna MM Hu, Yao Huang, Paul L Huffman, Jennifer E Ikram, M Arfan Ingelsson, Erik Jackson, Anne U Jansson, Jan-Håkan Jarvik, Gail P Jensen, Gorm B Jia, Yucheng Johansson, Stefan Jørgensen, Marit E Jørgensen, Torben Jukema, J Wouter Kahali, Bratati Kahn, René S Kähönen, Mika Kamstrup, Pia R Kanoni, Stavroula Kaprio, Jaakko Karaleftheri, Maria Kardia, Sharon LR Karpe, Fredrik Kathiresan, Sekar Kee, Frank Kiemeney, Lambertus A Kim, Eric Kitajima, Hidetoshi Komulainen, Pirjo Kooner, Jaspal S Kooperberg, Charles Korhonen, Tellervo Kovacs, Peter Kuivaniemi, Helena Kutalik, Zoltán Kuulasmaa, Kari Kuusisto, Johanna Laakso, Markku Lakka, Timo A Lamparter, David Lange, Ethan M Lange, Leslie A Langenberg, Claudia Larson, Eric B Lee, Nanette R Lehtimäki, Terho Lewis, Cora E Li, Huaixing Li, Jin Li-Gao, Ruifang Lin, Honghuang Lin, Keng-Hung Lin, Li-An Lin, Xu Lind, Lars Lindström, Jaana Linneberg, Allan Liu, Ching-Ti Liu, Dajiang J Liu, Yongmei Lo, Ken Sin Lophatananon, Artitaya Lotery, Andrew J Loukola, Anu Luan, Jian'an Lubitz, Steven A Lyytikäinen, Leo-Pekka Männistö, Satu Marenne, Gaëlle Mazul, Angela L McCarthy, Mark I McKean-Cowdin, Roberta Medland, Sarah E Meidtner, Karina Milani, Lili Mistry, Vanisha Mitchell, Paul Mohlke, Karen L Moilanen, Leena Moitry, Marie Montgomery, Grant W Mook-Kanamori, Dennis O Moore, Carmel Mori, Trevor A Morris, Andrew D Morris, Andrew P Müller-Nurasyid, Martina Munroe, Patricia B Nalls, Mike A Narisu, Narisu Nelson, Christopher P Neville, Matt Nielsen, Sune F Nikus, Kjell Njølstad, Pål R Nordestgaard, Børge G Nyholt, Dale R O'Connel, Jeffrey R O’Donoghue, Michelle L. Olde Loohuis, Loes M Ophoff, Roel A Owen, Katharine R Packard, Chris J Padmanabhan, Sandosh Palmer, Colin NA Palmer, Nicholette D Pasterkamp, Gerard Patel, Aniruddh P Pattie, Alison Pedersen, Oluf Peissig, Peggy L Peloso, Gina M Pennell, Craig E Perola, Markus Perry, James A Perry, John RB Pers, Tune H Person, Thomas N Peters, Annette Petersen, Eva RB Peyser, Patricia A Pirie, Ailith Polasek, Ozren Polderman, Tinca J Puolijoki, Hannu Raitakari, Olli T Rasheed, Asif Rauramaa, Rainer Reilly, Dermot F Renström, Frida Rheinberger, Myriam Ridker, Paul M Rioux, John D Rivas, Manuel A Roberts, David J Robertson, Neil R Robino, Antonietta Rolandsson, Olov Rudan, Igor Ruth, Katherine S Saleheen, Danish Salomaa, Veikko Samani, Nilesh J Sapkota, Yadav Sattar, Naveed Schoen, Robert E Schreiner, Pamela J Schulze, Matthias B Scott, Robert A Segura-Lepe, Marcelo P Shah, Svati H Sheu, Wayne H-H Sim, Xueling Slater, Andrew J Small, Kerrin S Smith, Albert Vernon Southam, Lorraine Spector, Timothy D Speliotes, Elizabeth K Starr, John M Stefansson, Kari Steinthorsdottir, Valgerdur Stirrups, Kathleen E Strauch, Konstantin Stringham, Heather M Stumvoll, Michael Sun, Liang Surendran, Praveen Swift, Amy J Tada, Hayato Tansey, Katherine E Tardif, Jean-Claude Taylor, Kent D Teumer, Alexander Thompson, Deborah J Thorleifsson, Gudmar Thorsteinsdottir, Unnur Thuesen, Betina H Tönjes, Anke Tromp, Gerard Trompet, Stella Tsafantakis, Emmanouil Tuomilehto, Jaakko Tybjaerg-Hansen, Anne Tyrer, Jonathan P Uher, Rudolf Uitterlinden, André G Uusitupa, Matti van der Laan, Sander W van Duijn, Cornelia M van Leeuwen, Nienke van Setten, Jessica Vanhala, Mauno Varbo, Anette Varga, Tibor V Varma, Rohit Velez Edwards, Digna R Vermeulen, Sita H Veronesi, Giovanni Vestergaard, Henrik Vitart, Veronique Vogt, Thomas F Völker, Uwe Vuckovic, Dragana Wagenknecht, Lynne E Walker, Mark Wallentin, Lars Wang, Feijie Wang, Carol A Wang, Shuai Wang, Yiqin Ware, Erin B Wareham, Nicholas J Warren, Helen R Waterworth, Dawn M Wessel, Jennifer White, Harvey D Willer, Cristen J Wilson, James G Witte, Daniel R Wood, Andrew R Wu, Ying Yaghootkar, Hanieh Yao, Jie Yao, Pang Yerges-Armstrong, Laura M Young, Robin Zeggini, Eleftheria Zhan, Xiaowei Zhang, Weihua Zhao, Jing Hua Zhao, Wei Zhao, Wei Zhou, Wei Zondervan, Krina T Rotter, Jerome I Pospisilik, John A Rivadeneira, Fernando Borecki, Ingrid B Deloukas, Panos Frayling, Timothy M Lettre, Guillaume North, Kari E Lindgren, Cecilia M Hirschhorn, Joel N Loos, Ruth JF
author_facet	Turcot, Valérie Lu, Yingchang Highland, Heather M Schurmann, Claudia Justice, Anne E Fine, Rebecca S Bradfield, Jonathan P Esko, Tõnu Giri, Ayush Graff, Mariaelisa Guo, Xiuqing Hendricks, Audrey E Karaderi, Tugce Lempradl, Adelheid Locke, Adam E Mahajan, Anubha Marouli, Eirini Sivapalaratnam, Suthesh Young, Kristin L Alfred, Tamuno Feitosa, Mary F Masca, Nicholas GD Manning, Alisa K Medina-Gomez, Carolina Mudgal, Poorva Ng, Maggie CY Reiner, Alex P Vedantam, Sailaja Willems, Sara M Winkler, Thomas W Abecasis, Goncalo Aben, Katja K Alam, Dewan S Alharthi, Sameer E Allison, Matthew Amouyel, Philippe Asselbergs, Folkert W Auer, Paul L Balkau, Beverley Bang, Lia E Barroso, Inês Bastarache, Lisa Benn, Marianne Bergmann, Sven Bielak, Lawrence F Blüher, Matthias Boehnke, Michael Boeing, Heiner Boerwinkle, Eric Böger, Carsten A Bork-Jensen, Jette Bots, Michiel L Bottinger, Erwin P Bowden, Donald W Brandslund, Ivan Breen, Gerome Brilliant, Murray H Broer, Linda Brumat, Marco Burt, Amber A Butterworth, Adam S Campbell, Peter T Cappellani, Stefania Carey, David J Catamo, Eulalia Caulfield, Mark J Chambers, John C Chasman, Daniel I Chen, Yii-Der Ida Chowdhury, Rajiv Christensen, Cramer Chu, Audrey Y Cocca, Massimiliano Collins, Francis S Cook, James P Corley, Janie Galbany, Jordi Corominas Cox, Amanda J Crosslin, David S Cuellar-Partida, Gabriel D'Eustacchio, Angela Danesh, John Davies, Gail de Bakker, Paul IW de Groot, Mark CH de Mutsert, Renée Deary, Ian J Dedoussis, George Demerath, Ellen W den Heijer, Martin den Hollander, Anneke I den Ruijter, Hester M Dennis, Joe G Denny, Josh C Di Angelantonio, Emanuele Drenos, Fotios Du, Mengmeng Dubé, Marie-Pierre Dunning, Alison M Easton, Douglas F Edwards, Todd L Ellinghaus, David Ellinor, Patrick T Elliott, Paul Evangelou, Evangelos Farmaki, Aliki-Eleni Farooqi, I. Sadaf Faul, Jessica D Fauser, Sascha Feng, Shuang Ferrannini, Ele Ferrieres, Jean Florez, Jose C Ford, Ian Fornage, Myriam Franco, Oscar H Franke, Andre Franks, Paul W Friedrich, Nele Frikke-Schmidt, Ruth Galesloot, Tessel E. Gan, Wei Gandin, Ilaria Gasparini, Paolo Gibson, Jane Giedraitis, Vilmantas Gjesing, Anette P Gordon-Larsen, Penny Gorski, Mathias Grabe, Hans-Jörgen Grant, Struan FA Grarup, Niels Griffiths, Helen L Grove, Megan L Gudnason, Vilmundur Gustafsson, Stefan Haessler, Jeff Hakonarson, Hakon Hammerschlag, Anke R Hansen, Torben Harris, Kathleen Mullan Harris, Tamara B Hattersley, Andrew T Have, Christian T Hayward, Caroline He, Liang Heard-Costa, Nancy L Heath, Andrew C Heid, Iris M Helgeland, Øyvind Hernesniemi, Jussi Hewitt, Alex W Holmen, Oddgeir L Hovingh, G Kees Howson, Joanna MM Hu, Yao Huang, Paul L Huffman, Jennifer E Ikram, M Arfan Ingelsson, Erik Jackson, Anne U Jansson, Jan-Håkan Jarvik, Gail P Jensen, Gorm B Jia, Yucheng Johansson, Stefan Jørgensen, Marit E Jørgensen, Torben Jukema, J Wouter Kahali, Bratati Kahn, René S Kähönen, Mika Kamstrup, Pia R Kanoni, Stavroula Kaprio, Jaakko Karaleftheri, Maria Kardia, Sharon LR Karpe, Fredrik Kathiresan, Sekar Kee, Frank Kiemeney, Lambertus A Kim, Eric Kitajima, Hidetoshi Komulainen, Pirjo Kooner, Jaspal S Kooperberg, Charles Korhonen, Tellervo Kovacs, Peter Kuivaniemi, Helena Kutalik, Zoltán Kuulasmaa, Kari Kuusisto, Johanna Laakso, Markku Lakka, Timo A Lamparter, David Lange, Ethan M Lange, Leslie A Langenberg, Claudia Larson, Eric B Lee, Nanette R Lehtimäki, Terho Lewis, Cora E Li, Huaixing Li, Jin Li-Gao, Ruifang Lin, Honghuang Lin, Keng-Hung Lin, Li-An Lin, Xu Lind, Lars Lindström, Jaana Linneberg, Allan Liu, Ching-Ti Liu, Dajiang J Liu, Yongmei Lo, Ken Sin Lophatananon, Artitaya Lotery, Andrew J Loukola, Anu Luan, Jian'an Lubitz, Steven A Lyytikäinen, Leo-Pekka Männistö, Satu Marenne, Gaëlle Mazul, Angela L McCarthy, Mark I McKean-Cowdin, Roberta Medland, Sarah E Meidtner, Karina Milani, Lili Mistry, Vanisha Mitchell, Paul Mohlke, Karen L Moilanen, Leena Moitry, Marie Montgomery, Grant W Mook-Kanamori, Dennis O Moore, Carmel Mori, Trevor A Morris, Andrew D Morris, Andrew P Müller-Nurasyid, Martina Munroe, Patricia B Nalls, Mike A Narisu, Narisu Nelson, Christopher P Neville, Matt Nielsen, Sune F Nikus, Kjell Njølstad, Pål R Nordestgaard, Børge G Nyholt, Dale R O'Connel, Jeffrey R O’Donoghue, Michelle L. Olde Loohuis, Loes M Ophoff, Roel A Owen, Katharine R Packard, Chris J Padmanabhan, Sandosh Palmer, Colin NA Palmer, Nicholette D Pasterkamp, Gerard Patel, Aniruddh P Pattie, Alison Pedersen, Oluf Peissig, Peggy L Peloso, Gina M Pennell, Craig E Perola, Markus Perry, James A Perry, John RB Pers, Tune H Person, Thomas N Peters, Annette Petersen, Eva RB Peyser, Patricia A Pirie, Ailith Polasek, Ozren Polderman, Tinca J Puolijoki, Hannu Raitakari, Olli T Rasheed, Asif Rauramaa, Rainer Reilly, Dermot F Renström, Frida Rheinberger, Myriam Ridker, Paul M Rioux, John D Rivas, Manuel A Roberts, David J Robertson, Neil R Robino, Antonietta Rolandsson, Olov Rudan, Igor Ruth, Katherine S Saleheen, Danish Salomaa, Veikko Samani, Nilesh J Sapkota, Yadav Sattar, Naveed Schoen, Robert E Schreiner, Pamela J Schulze, Matthias B Scott, Robert A Segura-Lepe, Marcelo P Shah, Svati H Sheu, Wayne H-H Sim, Xueling Slater, Andrew J Small, Kerrin S Smith, Albert Vernon Southam, Lorraine Spector, Timothy D Speliotes, Elizabeth K Starr, John M Stefansson, Kari Steinthorsdottir, Valgerdur Stirrups, Kathleen E Strauch, Konstantin Stringham, Heather M Stumvoll, Michael Sun, Liang Surendran, Praveen Swift, Amy J Tada, Hayato Tansey, Katherine E Tardif, Jean-Claude Taylor, Kent D Teumer, Alexander Thompson, Deborah J Thorleifsson, Gudmar Thorsteinsdottir, Unnur Thuesen, Betina H Tönjes, Anke Tromp, Gerard Trompet, Stella Tsafantakis, Emmanouil Tuomilehto, Jaakko Tybjaerg-Hansen, Anne Tyrer, Jonathan P Uher, Rudolf Uitterlinden, André G Uusitupa, Matti van der Laan, Sander W van Duijn, Cornelia M van Leeuwen, Nienke van Setten, Jessica Vanhala, Mauno Varbo, Anette Varga, Tibor V Varma, Rohit Velez Edwards, Digna R Vermeulen, Sita H Veronesi, Giovanni Vestergaard, Henrik Vitart, Veronique Vogt, Thomas F Völker, Uwe Vuckovic, Dragana Wagenknecht, Lynne E Walker, Mark Wallentin, Lars Wang, Feijie Wang, Carol A Wang, Shuai Wang, Yiqin Ware, Erin B Wareham, Nicholas J Warren, Helen R Waterworth, Dawn M Wessel, Jennifer White, Harvey D Willer, Cristen J Wilson, James G Witte, Daniel R Wood, Andrew R Wu, Ying Yaghootkar, Hanieh Yao, Jie Yao, Pang Yerges-Armstrong, Laura M Young, Robin Zeggini, Eleftheria Zhan, Xiaowei Zhang, Weihua Zhao, Jing Hua Zhao, Wei Zhao, Wei Zhou, Wei Zondervan, Krina T Rotter, Jerome I Pospisilik, John A Rivadeneira, Fernando Borecki, Ingrid B Deloukas, Panos Frayling, Timothy M Lettre, Guillaume North, Kari E Lindgren, Cecilia M Hirschhorn, Joel N Loos, Ruth JF
author_sort	Turcot, Valérie
collection	PubMed
description	Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, non-coding variants from which pinpointing causal genes remains challenging. Here, we combined data from 718,734 individuals to discover rare and low-frequency (MAF<5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which eight in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2, ZNF169) newly implicated in human obesity, two (MC4R, KSR2) previously observed in extreme obesity, and two variants in GIPR. Effect sizes of rare variants are ~10 times larger than of common variants, with the largest effect observed in carriers of an MC4R stop-codon (p.Tyr35Ter, MAF=0.01%), weighing ~7kg more than non-carriers. Pathway analyses confirmed enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically-supported therapeutic targets to treat obesity.
format	Online Article Text
id	pubmed-5945951
institution	National Center for Biotechnology Information
language	English
publishDate	2017
record_format	MEDLINE/PubMed
spelling	pubmed-59459512018-06-22 Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity Turcot, Valérie Lu, Yingchang Highland, Heather M Schurmann, Claudia Justice, Anne E Fine, Rebecca S Bradfield, Jonathan P Esko, Tõnu Giri, Ayush Graff, Mariaelisa Guo, Xiuqing Hendricks, Audrey E Karaderi, Tugce Lempradl, Adelheid Locke, Adam E Mahajan, Anubha Marouli, Eirini Sivapalaratnam, Suthesh Young, Kristin L Alfred, Tamuno Feitosa, Mary F Masca, Nicholas GD Manning, Alisa K Medina-Gomez, Carolina Mudgal, Poorva Ng, Maggie CY Reiner, Alex P Vedantam, Sailaja Willems, Sara M Winkler, Thomas W Abecasis, Goncalo Aben, Katja K Alam, Dewan S Alharthi, Sameer E Allison, Matthew Amouyel, Philippe Asselbergs, Folkert W Auer, Paul L Balkau, Beverley Bang, Lia E Barroso, Inês Bastarache, Lisa Benn, Marianne Bergmann, Sven Bielak, Lawrence F Blüher, Matthias Boehnke, Michael Boeing, Heiner Boerwinkle, Eric Böger, Carsten A Bork-Jensen, Jette Bots, Michiel L Bottinger, Erwin P Bowden, Donald W Brandslund, Ivan Breen, Gerome Brilliant, Murray H Broer, Linda Brumat, Marco Burt, Amber A Butterworth, Adam S Campbell, Peter T Cappellani, Stefania Carey, David J Catamo, Eulalia Caulfield, Mark J Chambers, John C Chasman, Daniel I Chen, Yii-Der Ida Chowdhury, Rajiv Christensen, Cramer Chu, Audrey Y Cocca, Massimiliano Collins, Francis S Cook, James P Corley, Janie Galbany, Jordi Corominas Cox, Amanda J Crosslin, David S Cuellar-Partida, Gabriel D'Eustacchio, Angela Danesh, John Davies, Gail de Bakker, Paul IW de Groot, Mark CH de Mutsert, Renée Deary, Ian J Dedoussis, George Demerath, Ellen W den Heijer, Martin den Hollander, Anneke I den Ruijter, Hester M Dennis, Joe G Denny, Josh C Di Angelantonio, Emanuele Drenos, Fotios Du, Mengmeng Dubé, Marie-Pierre Dunning, Alison M Easton, Douglas F Edwards, Todd L Ellinghaus, David Ellinor, Patrick T Elliott, Paul Evangelou, Evangelos Farmaki, Aliki-Eleni Farooqi, I. Sadaf Faul, Jessica D Fauser, Sascha Feng, Shuang Ferrannini, Ele Ferrieres, Jean Florez, Jose C Ford, Ian Fornage, Myriam Franco, Oscar H Franke, Andre Franks, Paul W Friedrich, Nele Frikke-Schmidt, Ruth Galesloot, Tessel E. Gan, Wei Gandin, Ilaria Gasparini, Paolo Gibson, Jane Giedraitis, Vilmantas Gjesing, Anette P Gordon-Larsen, Penny Gorski, Mathias Grabe, Hans-Jörgen Grant, Struan FA Grarup, Niels Griffiths, Helen L Grove, Megan L Gudnason, Vilmundur Gustafsson, Stefan Haessler, Jeff Hakonarson, Hakon Hammerschlag, Anke R Hansen, Torben Harris, Kathleen Mullan Harris, Tamara B Hattersley, Andrew T Have, Christian T Hayward, Caroline He, Liang Heard-Costa, Nancy L Heath, Andrew C Heid, Iris M Helgeland, Øyvind Hernesniemi, Jussi Hewitt, Alex W Holmen, Oddgeir L Hovingh, G Kees Howson, Joanna MM Hu, Yao Huang, Paul L Huffman, Jennifer E Ikram, M Arfan Ingelsson, Erik Jackson, Anne U Jansson, Jan-Håkan Jarvik, Gail P Jensen, Gorm B Jia, Yucheng Johansson, Stefan Jørgensen, Marit E Jørgensen, Torben Jukema, J Wouter Kahali, Bratati Kahn, René S Kähönen, Mika Kamstrup, Pia R Kanoni, Stavroula Kaprio, Jaakko Karaleftheri, Maria Kardia, Sharon LR Karpe, Fredrik Kathiresan, Sekar Kee, Frank Kiemeney, Lambertus A Kim, Eric Kitajima, Hidetoshi Komulainen, Pirjo Kooner, Jaspal S Kooperberg, Charles Korhonen, Tellervo Kovacs, Peter Kuivaniemi, Helena Kutalik, Zoltán Kuulasmaa, Kari Kuusisto, Johanna Laakso, Markku Lakka, Timo A Lamparter, David Lange, Ethan M Lange, Leslie A Langenberg, Claudia Larson, Eric B Lee, Nanette R Lehtimäki, Terho Lewis, Cora E Li, Huaixing Li, Jin Li-Gao, Ruifang Lin, Honghuang Lin, Keng-Hung Lin, Li-An Lin, Xu Lind, Lars Lindström, Jaana Linneberg, Allan Liu, Ching-Ti Liu, Dajiang J Liu, Yongmei Lo, Ken Sin Lophatananon, Artitaya Lotery, Andrew J Loukola, Anu Luan, Jian'an Lubitz, Steven A Lyytikäinen, Leo-Pekka Männistö, Satu Marenne, Gaëlle Mazul, Angela L McCarthy, Mark I McKean-Cowdin, Roberta Medland, Sarah E Meidtner, Karina Milani, Lili Mistry, Vanisha Mitchell, Paul Mohlke, Karen L Moilanen, Leena Moitry, Marie Montgomery, Grant W Mook-Kanamori, Dennis O Moore, Carmel Mori, Trevor A Morris, Andrew D Morris, Andrew P Müller-Nurasyid, Martina Munroe, Patricia B Nalls, Mike A Narisu, Narisu Nelson, Christopher P Neville, Matt Nielsen, Sune F Nikus, Kjell Njølstad, Pål R Nordestgaard, Børge G Nyholt, Dale R O'Connel, Jeffrey R O’Donoghue, Michelle L. Olde Loohuis, Loes M Ophoff, Roel A Owen, Katharine R Packard, Chris J Padmanabhan, Sandosh Palmer, Colin NA Palmer, Nicholette D Pasterkamp, Gerard Patel, Aniruddh P Pattie, Alison Pedersen, Oluf Peissig, Peggy L Peloso, Gina M Pennell, Craig E Perola, Markus Perry, James A Perry, John RB Pers, Tune H Person, Thomas N Peters, Annette Petersen, Eva RB Peyser, Patricia A Pirie, Ailith Polasek, Ozren Polderman, Tinca J Puolijoki, Hannu Raitakari, Olli T Rasheed, Asif Rauramaa, Rainer Reilly, Dermot F Renström, Frida Rheinberger, Myriam Ridker, Paul M Rioux, John D Rivas, Manuel A Roberts, David J Robertson, Neil R Robino, Antonietta Rolandsson, Olov Rudan, Igor Ruth, Katherine S Saleheen, Danish Salomaa, Veikko Samani, Nilesh J Sapkota, Yadav Sattar, Naveed Schoen, Robert E Schreiner, Pamela J Schulze, Matthias B Scott, Robert A Segura-Lepe, Marcelo P Shah, Svati H Sheu, Wayne H-H Sim, Xueling Slater, Andrew J Small, Kerrin S Smith, Albert Vernon Southam, Lorraine Spector, Timothy D Speliotes, Elizabeth K Starr, John M Stefansson, Kari Steinthorsdottir, Valgerdur Stirrups, Kathleen E Strauch, Konstantin Stringham, Heather M Stumvoll, Michael Sun, Liang Surendran, Praveen Swift, Amy J Tada, Hayato Tansey, Katherine E Tardif, Jean-Claude Taylor, Kent D Teumer, Alexander Thompson, Deborah J Thorleifsson, Gudmar Thorsteinsdottir, Unnur Thuesen, Betina H Tönjes, Anke Tromp, Gerard Trompet, Stella Tsafantakis, Emmanouil Tuomilehto, Jaakko Tybjaerg-Hansen, Anne Tyrer, Jonathan P Uher, Rudolf Uitterlinden, André G Uusitupa, Matti van der Laan, Sander W van Duijn, Cornelia M van Leeuwen, Nienke van Setten, Jessica Vanhala, Mauno Varbo, Anette Varga, Tibor V Varma, Rohit Velez Edwards, Digna R Vermeulen, Sita H Veronesi, Giovanni Vestergaard, Henrik Vitart, Veronique Vogt, Thomas F Völker, Uwe Vuckovic, Dragana Wagenknecht, Lynne E Walker, Mark Wallentin, Lars Wang, Feijie Wang, Carol A Wang, Shuai Wang, Yiqin Ware, Erin B Wareham, Nicholas J Warren, Helen R Waterworth, Dawn M Wessel, Jennifer White, Harvey D Willer, Cristen J Wilson, James G Witte, Daniel R Wood, Andrew R Wu, Ying Yaghootkar, Hanieh Yao, Jie Yao, Pang Yerges-Armstrong, Laura M Young, Robin Zeggini, Eleftheria Zhan, Xiaowei Zhang, Weihua Zhao, Jing Hua Zhao, Wei Zhao, Wei Zhou, Wei Zondervan, Krina T Rotter, Jerome I Pospisilik, John A Rivadeneira, Fernando Borecki, Ingrid B Deloukas, Panos Frayling, Timothy M Lettre, Guillaume North, Kari E Lindgren, Cecilia M Hirschhorn, Joel N Loos, Ruth JF Nat Genet Article Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, non-coding variants from which pinpointing causal genes remains challenging. Here, we combined data from 718,734 individuals to discover rare and low-frequency (MAF<5%) coding variants associated with BMI. We identified 14 coding variants in 13 genes, of which eight in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2, ZNF169) newly implicated in human obesity, two (MC4R, KSR2) previously observed in extreme obesity, and two variants in GIPR. Effect sizes of rare variants are ~10 times larger than of common variants, with the largest effect observed in carriers of an MC4R stop-codon (p.Tyr35Ter, MAF=0.01%), weighing ~7kg more than non-carriers. Pathway analyses confirmed enrichment of neuronal genes and provide new evidence for adipocyte and energy expenditure biology, widening the potential of genetically-supported therapeutic targets to treat obesity. 2017-12-22 2018-01 /pmc/articles/PMC5945951/ /pubmed/29273807 http://dx.doi.org/10.1038/s41588-017-0011-x Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle	Article Turcot, Valérie Lu, Yingchang Highland, Heather M Schurmann, Claudia Justice, Anne E Fine, Rebecca S Bradfield, Jonathan P Esko, Tõnu Giri, Ayush Graff, Mariaelisa Guo, Xiuqing Hendricks, Audrey E Karaderi, Tugce Lempradl, Adelheid Locke, Adam E Mahajan, Anubha Marouli, Eirini Sivapalaratnam, Suthesh Young, Kristin L Alfred, Tamuno Feitosa, Mary F Masca, Nicholas GD Manning, Alisa K Medina-Gomez, Carolina Mudgal, Poorva Ng, Maggie CY Reiner, Alex P Vedantam, Sailaja Willems, Sara M Winkler, Thomas W Abecasis, Goncalo Aben, Katja K Alam, Dewan S Alharthi, Sameer E Allison, Matthew Amouyel, Philippe Asselbergs, Folkert W Auer, Paul L Balkau, Beverley Bang, Lia E Barroso, Inês Bastarache, Lisa Benn, Marianne Bergmann, Sven Bielak, Lawrence F Blüher, Matthias Boehnke, Michael Boeing, Heiner Boerwinkle, Eric Böger, Carsten A Bork-Jensen, Jette Bots, Michiel L Bottinger, Erwin P Bowden, Donald W Brandslund, Ivan Breen, Gerome Brilliant, Murray H Broer, Linda Brumat, Marco Burt, Amber A Butterworth, Adam S Campbell, Peter T Cappellani, Stefania Carey, David J Catamo, Eulalia Caulfield, Mark J Chambers, John C Chasman, Daniel I Chen, Yii-Der Ida Chowdhury, Rajiv Christensen, Cramer Chu, Audrey Y Cocca, Massimiliano Collins, Francis S Cook, James P Corley, Janie Galbany, Jordi Corominas Cox, Amanda J Crosslin, David S Cuellar-Partida, Gabriel D'Eustacchio, Angela Danesh, John Davies, Gail de Bakker, Paul IW de Groot, Mark CH de Mutsert, Renée Deary, Ian J Dedoussis, George Demerath, Ellen W den Heijer, Martin den Hollander, Anneke I den Ruijter, Hester M Dennis, Joe G Denny, Josh C Di Angelantonio, Emanuele Drenos, Fotios Du, Mengmeng Dubé, Marie-Pierre Dunning, Alison M Easton, Douglas F Edwards, Todd L Ellinghaus, David Ellinor, Patrick T Elliott, Paul Evangelou, Evangelos Farmaki, Aliki-Eleni Farooqi, I. Sadaf Faul, Jessica D Fauser, Sascha Feng, Shuang Ferrannini, Ele Ferrieres, Jean Florez, Jose C Ford, Ian Fornage, Myriam Franco, Oscar H Franke, Andre Franks, Paul W Friedrich, Nele Frikke-Schmidt, Ruth Galesloot, Tessel E. Gan, Wei Gandin, Ilaria Gasparini, Paolo Gibson, Jane Giedraitis, Vilmantas Gjesing, Anette P Gordon-Larsen, Penny Gorski, Mathias Grabe, Hans-Jörgen Grant, Struan FA Grarup, Niels Griffiths, Helen L Grove, Megan L Gudnason, Vilmundur Gustafsson, Stefan Haessler, Jeff Hakonarson, Hakon Hammerschlag, Anke R Hansen, Torben Harris, Kathleen Mullan Harris, Tamara B Hattersley, Andrew T Have, Christian T Hayward, Caroline He, Liang Heard-Costa, Nancy L Heath, Andrew C Heid, Iris M Helgeland, Øyvind Hernesniemi, Jussi Hewitt, Alex W Holmen, Oddgeir L Hovingh, G Kees Howson, Joanna MM Hu, Yao Huang, Paul L Huffman, Jennifer E Ikram, M Arfan Ingelsson, Erik Jackson, Anne U Jansson, Jan-Håkan Jarvik, Gail P Jensen, Gorm B Jia, Yucheng Johansson, Stefan Jørgensen, Marit E Jørgensen, Torben Jukema, J Wouter Kahali, Bratati Kahn, René S Kähönen, Mika Kamstrup, Pia R Kanoni, Stavroula Kaprio, Jaakko Karaleftheri, Maria Kardia, Sharon LR Karpe, Fredrik Kathiresan, Sekar Kee, Frank Kiemeney, Lambertus A Kim, Eric Kitajima, Hidetoshi Komulainen, Pirjo Kooner, Jaspal S Kooperberg, Charles Korhonen, Tellervo Kovacs, Peter Kuivaniemi, Helena Kutalik, Zoltán Kuulasmaa, Kari Kuusisto, Johanna Laakso, Markku Lakka, Timo A Lamparter, David Lange, Ethan M Lange, Leslie A Langenberg, Claudia Larson, Eric B Lee, Nanette R Lehtimäki, Terho Lewis, Cora E Li, Huaixing Li, Jin Li-Gao, Ruifang Lin, Honghuang Lin, Keng-Hung Lin, Li-An Lin, Xu Lind, Lars Lindström, Jaana Linneberg, Allan Liu, Ching-Ti Liu, Dajiang J Liu, Yongmei Lo, Ken Sin Lophatananon, Artitaya Lotery, Andrew J Loukola, Anu Luan, Jian'an Lubitz, Steven A Lyytikäinen, Leo-Pekka Männistö, Satu Marenne, Gaëlle Mazul, Angela L McCarthy, Mark I McKean-Cowdin, Roberta Medland, Sarah E Meidtner, Karina Milani, Lili Mistry, Vanisha Mitchell, Paul Mohlke, Karen L Moilanen, Leena Moitry, Marie Montgomery, Grant W Mook-Kanamori, Dennis O Moore, Carmel Mori, Trevor A Morris, Andrew D Morris, Andrew P Müller-Nurasyid, Martina Munroe, Patricia B Nalls, Mike A Narisu, Narisu Nelson, Christopher P Neville, Matt Nielsen, Sune F Nikus, Kjell Njølstad, Pål R Nordestgaard, Børge G Nyholt, Dale R O'Connel, Jeffrey R O’Donoghue, Michelle L. Olde Loohuis, Loes M Ophoff, Roel A Owen, Katharine R Packard, Chris J Padmanabhan, Sandosh Palmer, Colin NA Palmer, Nicholette D Pasterkamp, Gerard Patel, Aniruddh P Pattie, Alison Pedersen, Oluf Peissig, Peggy L Peloso, Gina M Pennell, Craig E Perola, Markus Perry, James A Perry, John RB Pers, Tune H Person, Thomas N Peters, Annette Petersen, Eva RB Peyser, Patricia A Pirie, Ailith Polasek, Ozren Polderman, Tinca J Puolijoki, Hannu Raitakari, Olli T Rasheed, Asif Rauramaa, Rainer Reilly, Dermot F Renström, Frida Rheinberger, Myriam Ridker, Paul M Rioux, John D Rivas, Manuel A Roberts, David J Robertson, Neil R Robino, Antonietta Rolandsson, Olov Rudan, Igor Ruth, Katherine S Saleheen, Danish Salomaa, Veikko Samani, Nilesh J Sapkota, Yadav Sattar, Naveed Schoen, Robert E Schreiner, Pamela J Schulze, Matthias B Scott, Robert A Segura-Lepe, Marcelo P Shah, Svati H Sheu, Wayne H-H Sim, Xueling Slater, Andrew J Small, Kerrin S Smith, Albert Vernon Southam, Lorraine Spector, Timothy D Speliotes, Elizabeth K Starr, John M Stefansson, Kari Steinthorsdottir, Valgerdur Stirrups, Kathleen E Strauch, Konstantin Stringham, Heather M Stumvoll, Michael Sun, Liang Surendran, Praveen Swift, Amy J Tada, Hayato Tansey, Katherine E Tardif, Jean-Claude Taylor, Kent D Teumer, Alexander Thompson, Deborah J Thorleifsson, Gudmar Thorsteinsdottir, Unnur Thuesen, Betina H Tönjes, Anke Tromp, Gerard Trompet, Stella Tsafantakis, Emmanouil Tuomilehto, Jaakko Tybjaerg-Hansen, Anne Tyrer, Jonathan P Uher, Rudolf Uitterlinden, André G Uusitupa, Matti van der Laan, Sander W van Duijn, Cornelia M van Leeuwen, Nienke van Setten, Jessica Vanhala, Mauno Varbo, Anette Varga, Tibor V Varma, Rohit Velez Edwards, Digna R Vermeulen, Sita H Veronesi, Giovanni Vestergaard, Henrik Vitart, Veronique Vogt, Thomas F Völker, Uwe Vuckovic, Dragana Wagenknecht, Lynne E Walker, Mark Wallentin, Lars Wang, Feijie Wang, Carol A Wang, Shuai Wang, Yiqin Ware, Erin B Wareham, Nicholas J Warren, Helen R Waterworth, Dawn M Wessel, Jennifer White, Harvey D Willer, Cristen J Wilson, James G Witte, Daniel R Wood, Andrew R Wu, Ying Yaghootkar, Hanieh Yao, Jie Yao, Pang Yerges-Armstrong, Laura M Young, Robin Zeggini, Eleftheria Zhan, Xiaowei Zhang, Weihua Zhao, Jing Hua Zhao, Wei Zhao, Wei Zhou, Wei Zondervan, Krina T Rotter, Jerome I Pospisilik, John A Rivadeneira, Fernando Borecki, Ingrid B Deloukas, Panos Frayling, Timothy M Lettre, Guillaume North, Kari E Lindgren, Cecilia M Hirschhorn, Joel N Loos, Ruth JF Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity
title	Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity
title_full	Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity
title_fullStr	Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity
title_full_unstemmed	Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity
title_short	Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity
title_sort	protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity
topic	Article
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945951/ https://www.ncbi.nlm.nih.gov/pubmed/29273807 http://dx.doi.org/10.1038/s41588-017-0011-x
work_keys_str_mv	AT turcotvalerie proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT luyingchang proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT highlandheatherm proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT schurmannclaudia proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT justiceannee proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT finerebeccas proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT bradfieldjonathanp proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT eskotonu proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT giriayush proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT graffmariaelisa proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT guoxiuqing proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT hendricksaudreye proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT karaderitugce proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT lempradladelheid proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT lockeadame proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT mahajananubha proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT maroulieirini proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT sivapalaratnamsuthesh proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT youngkristinl proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT alfredtamuno proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT feitosamaryf proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT mascanicholasgd proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT manningalisak proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT medinagomezcarolina proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT mudgalpoorva proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT ngmaggiecy proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT reineralexp proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT vedantamsailaja proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT willemssaram proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT winklerthomasw proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT abecasisgoncalo proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT abenkatjak proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT alamdewans proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT alharthisameere proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT allisonmatthew proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT amouyelphilippe proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT asselbergsfolkertw proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT auerpaull proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT balkaubeverley proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT bangliae proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT barrosoines proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT bastarachelisa proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT bennmarianne proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT bergmannsven proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT bielaklawrencef proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT bluhermatthias proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT boehnkemichael proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT boeingheiner proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT boerwinkleeric proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT bogercarstena proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT borkjensenjette proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT botsmichiell proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT bottingererwinp proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT bowdendonaldw proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT brandslundivan proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT breengerome proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT brilliantmurrayh proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT broerlinda proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT brumatmarco proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT burtambera proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT butterworthadams proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT campbellpetert proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT cappellanistefania proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT careydavidj proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT catamoeulalia proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT caulfieldmarkj proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT chambersjohnc proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT chasmandanieli proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT chenyiiderida proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT chowdhuryrajiv proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT christensencramer proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT chuaudreyy proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT coccamassimiliano proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT collinsfranciss proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT cookjamesp proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT corleyjanie proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT galbanyjordicorominas proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT coxamandaj proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT crosslindavids proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT cuellarpartidagabriel proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT deustacchioangela proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT daneshjohn proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT daviesgail proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT debakkerpauliw proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT degrootmarkch proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT demutsertrenee proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT dearyianj proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT dedoussisgeorge proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT demerathellenw proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT denheijermartin proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT denhollanderannekei proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT denruijterhesterm proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT dennisjoeg proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT dennyjoshc proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT diangelantonioemanuele proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT drenosfotios proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT dumengmeng proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT dubemariepierre proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT dunningalisonm proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT eastondouglasf proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT edwardstoddl proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT ellinghausdavid proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT ellinorpatrickt proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT elliottpaul proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT evangelouevangelos proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT farmakialikieleni proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT farooqiisadaf proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT fauljessicad proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT fausersascha proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT fengshuang proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT ferranniniele proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT ferrieresjean proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT florezjosec proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT fordian proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT fornagemyriam proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT francooscarh proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT frankeandre proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT frankspaulw proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT friedrichnele proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT frikkeschmidtruth proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT galesloottessele proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT ganwei proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT gandinilaria proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT gasparinipaolo proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT gibsonjane proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT giedraitisvilmantas proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT gjesinganettep proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT gordonlarsenpenny proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT gorskimathias proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT grabehansjorgen proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT grantstruanfa proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT grarupniels proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT griffithshelenl proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT grovemeganl proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT gudnasonvilmundur proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT gustafssonstefan proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT haesslerjeff proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT hakonarsonhakon proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT hammerschlaganker proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT hansentorben proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT harriskathleenmullan proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT harristamarab proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT hattersleyandrewt proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT havechristiant proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT haywardcaroline proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT heliang proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT heardcostanancyl proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT heathandrewc proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT heidirism proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT helgelandøyvind proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT hernesniemijussi proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT hewittalexw proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT holmenoddgeirl proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT hovinghgkees proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT howsonjoannamm proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT huyao proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT huangpaull proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT huffmanjennifere proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT ikrammarfan proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT ingelssonerik proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT jacksonanneu proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT janssonjanhakan proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT jarvikgailp proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT jensengormb proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT jiayucheng proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT johanssonstefan proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT jørgensenmarite proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT jørgensentorben proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT jukemajwouter proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT kahalibratati proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT kahnrenes proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT kahonenmika proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT kamstruppiar proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT kanonistavroula proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT kapriojaakko proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT karaleftherimaria proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT kardiasharonlr proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT karpefredrik proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT kathiresansekar proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT keefrank proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT kiemeneylambertusa proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT kimeric proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT kitajimahidetoshi proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT komulainenpirjo proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT koonerjaspals proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT kooperbergcharles proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT korhonentellervo proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT kovacspeter proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT kuivaniemihelena proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT kutalikzoltan proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT kuulasmaakari proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT kuusistojohanna proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT laaksomarkku proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT lakkatimoa proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT lamparterdavid proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT langeethanm proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT langelesliea proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT langenbergclaudia proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT larsonericb proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT leenanetter proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT lehtimakiterho proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT lewiscorae proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT lihuaixing proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT lijin proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT ligaoruifang proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT linhonghuang proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT linkenghung proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT linlian proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT linxu proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT lindlars proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT lindstromjaana proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT linnebergallan proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT liuchingti proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT liudajiangj proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT liuyongmei proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT lokensin proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT lophatananonartitaya proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT loteryandrewj proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT loukolaanu proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT luanjianan proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT lubitzstevena proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT lyytikainenleopekka proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT mannistosatu proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT marennegaelle proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT mazulangelal proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT mccarthymarki proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT mckeancowdinroberta proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT medlandsarahe proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT meidtnerkarina proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT milanilili proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT mistryvanisha proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT mitchellpaul proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT mohlkekarenl proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT moilanenleena proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT moitrymarie proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT montgomerygrantw proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT mookkanamoridenniso proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT moorecarmel proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT moritrevora proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT morrisandrewd proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT morrisandrewp proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT mullernurasyidmartina proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT munroepatriciab proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT nallsmikea proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT narisunarisu proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT nelsonchristopherp proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT nevillematt proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT nielsensunef proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT nikuskjell proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT njølstadpalr proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT nordestgaardbørgeg proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT nyholtdaler proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT oconneljeffreyr proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT odonoghuemichellel proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT oldeloohuisloesm proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT ophoffroela proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT owenkathariner proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT packardchrisj proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT padmanabhansandosh proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT palmercolinna proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT palmernicholetted proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT pasterkampgerard proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT patelaniruddhp proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT pattiealison proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT pedersenoluf proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT peissigpeggyl proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT pelosoginam proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT pennellcraige proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT perolamarkus proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT perryjamesa proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT perryjohnrb proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT perstuneh proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT personthomasn proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT petersannette proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT petersenevarb proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT peyserpatriciaa proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT pirieailith proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT polasekozren proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT poldermantincaj proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT puolijokihannu proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT raitakariollit proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT rasheedasif proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT rauramaarainer proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT reillydermotf proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT renstromfrida proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT rheinbergermyriam proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT ridkerpaulm proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT riouxjohnd proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT rivasmanuela proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT robertsdavidj proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT robertsonneilr proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT robinoantonietta proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT rolandssonolov proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT rudanigor proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT ruthkatherines proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT saleheendanish proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT salomaaveikko proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT samaninileshj proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT sapkotayadav proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT sattarnaveed proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT schoenroberte proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT schreinerpamelaj proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT schulzematthiasb proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT scottroberta proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT seguralepemarcelop proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT shahsvatih proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT sheuwaynehh proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT simxueling proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT slaterandrewj proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT smallkerrins proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT smithalbertvernon proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT southamlorraine proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT spectortimothyd proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT spelioteselizabethk proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT starrjohnm proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT stefanssonkari proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT steinthorsdottirvalgerdur proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT stirrupskathleene proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT strauchkonstantin proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT stringhamheatherm proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT stumvollmichael proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT sunliang proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT surendranpraveen proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT swiftamyj proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT tadahayato proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT tanseykatherinee proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT tardifjeanclaude proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT taylorkentd proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT teumeralexander proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT thompsondeborahj proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT thorleifssongudmar proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT thorsteinsdottirunnur proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT thuesenbetinah proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT tonjesanke proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT trompgerard proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT trompetstella proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT tsafantakisemmanouil proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT tuomilehtojaakko proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT tybjaerghansenanne proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT tyrerjonathanp proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT uherrudolf proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT uitterlindenandreg proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT uusitupamatti proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT vanderlaansanderw proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT vanduijncorneliam proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT vanleeuwennienke proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT vansettenjessica proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT vanhalamauno proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT varboanette proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT vargatiborv proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT varmarohit proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT velezedwardsdignar proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT vermeulensitah proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT veronesigiovanni proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT vestergaardhenrik proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT vitartveronique proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT vogtthomasf proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT volkeruwe proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT vuckovicdragana proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT wagenknechtlynnee proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT walkermark proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT wallentinlars proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT wangfeijie proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT wangcarola proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT wangshuai proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT wangyiqin proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT wareerinb proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT warehamnicholasj proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT warrenhelenr proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT waterworthdawnm proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT wesseljennifer proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT whiteharveyd proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT willercristenj proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT wilsonjamesg proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT wittedanielr proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT woodandrewr proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT wuying proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT yaghootkarhanieh proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT yaojie proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT yaopang proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT yergesarmstronglauram proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT youngrobin proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT zegginieleftheria proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT zhanxiaowei proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT zhangweihua proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT zhaojinghua proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT zhaowei proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT zhaowei proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT zhouwei proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT zondervankrinat proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT rotterjeromei proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT pospisilikjohna proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT rivadeneirafernando proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT boreckiingridb proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT deloukaspanos proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT fraylingtimothym proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT lettreguillaume proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT northkarie proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT lindgrenceciliam proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT hirschhornjoeln proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity AT loosruthjf proteinalteringvariantsassociatedwithbodymassindeximplicatepathwaysthatcontrolenergyintakeandexpenditureunderpinningobesity

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure underpinning obesity

Ejemplares similares