Elevated LGI1‐IgG CSF index predicts worse neurological outcome

To determine whether CSF leucine‐rich glioma‐inactivated 1(LGI1)‐IgG titer, index or IgG subclass has prognostic significance, we tested serum and CSF specimens collected concomitantly from 39 seropositive patients. LGI1‐IgG index was elevated (>1) in 21 patients (54%), suggesting intrathecal syn...

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Autores principales: Gadoth, Avi, Zekeridou, Anastasia, Klein, Christopher J., Thoreson, Colton J., Majed, Masoud, Dubey, Divyanshu, Flanagan, Eoin P., McKeon, Andrew, Jenkins, Sarah M., Lennon, Vanda A., Pittock, Sean J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945965/
https://www.ncbi.nlm.nih.gov/pubmed/29761127
http://dx.doi.org/10.1002/acn3.561
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author Gadoth, Avi
Zekeridou, Anastasia
Klein, Christopher J.
Thoreson, Colton J.
Majed, Masoud
Dubey, Divyanshu
Flanagan, Eoin P.
McKeon, Andrew
Jenkins, Sarah M.
Lennon, Vanda A.
Pittock, Sean J.
author_facet Gadoth, Avi
Zekeridou, Anastasia
Klein, Christopher J.
Thoreson, Colton J.
Majed, Masoud
Dubey, Divyanshu
Flanagan, Eoin P.
McKeon, Andrew
Jenkins, Sarah M.
Lennon, Vanda A.
Pittock, Sean J.
author_sort Gadoth, Avi
collection PubMed
description To determine whether CSF leucine‐rich glioma‐inactivated 1(LGI1)‐IgG titer, index or IgG subclass has prognostic significance, we tested serum and CSF specimens collected concomitantly from 39 seropositive patients. LGI1‐IgG index was elevated (>1) in 21 patients (54%), suggesting intrathecal synthesis. Patients with worse outcome at last follow‐up (modified Rankin Scale >2) had significantly higher index (median 6.57 vs. 0.5, P = 0.048) compared to those with better outcome. Higher CSF LGI1‐IgG4 subclass‐specific titer and index correlated with worse outcome (P < 0.005 for both). These data suggest that evidence of intrathecal LGI1‐IgG synthesis may correlate with neuronal injury and warrant consideration of aggressive immunotherapy.
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spelling pubmed-59459652018-05-14 Elevated LGI1‐IgG CSF index predicts worse neurological outcome Gadoth, Avi Zekeridou, Anastasia Klein, Christopher J. Thoreson, Colton J. Majed, Masoud Dubey, Divyanshu Flanagan, Eoin P. McKeon, Andrew Jenkins, Sarah M. Lennon, Vanda A. Pittock, Sean J. Ann Clin Transl Neurol Brief Communications To determine whether CSF leucine‐rich glioma‐inactivated 1(LGI1)‐IgG titer, index or IgG subclass has prognostic significance, we tested serum and CSF specimens collected concomitantly from 39 seropositive patients. LGI1‐IgG index was elevated (>1) in 21 patients (54%), suggesting intrathecal synthesis. Patients with worse outcome at last follow‐up (modified Rankin Scale >2) had significantly higher index (median 6.57 vs. 0.5, P = 0.048) compared to those with better outcome. Higher CSF LGI1‐IgG4 subclass‐specific titer and index correlated with worse outcome (P < 0.005 for both). These data suggest that evidence of intrathecal LGI1‐IgG synthesis may correlate with neuronal injury and warrant consideration of aggressive immunotherapy. John Wiley and Sons Inc. 2018-04-02 /pmc/articles/PMC5945965/ /pubmed/29761127 http://dx.doi.org/10.1002/acn3.561 Text en © 2018 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Brief Communications
Gadoth, Avi
Zekeridou, Anastasia
Klein, Christopher J.
Thoreson, Colton J.
Majed, Masoud
Dubey, Divyanshu
Flanagan, Eoin P.
McKeon, Andrew
Jenkins, Sarah M.
Lennon, Vanda A.
Pittock, Sean J.
Elevated LGI1‐IgG CSF index predicts worse neurological outcome
title Elevated LGI1‐IgG CSF index predicts worse neurological outcome
title_full Elevated LGI1‐IgG CSF index predicts worse neurological outcome
title_fullStr Elevated LGI1‐IgG CSF index predicts worse neurological outcome
title_full_unstemmed Elevated LGI1‐IgG CSF index predicts worse neurological outcome
title_short Elevated LGI1‐IgG CSF index predicts worse neurological outcome
title_sort elevated lgi1‐igg csf index predicts worse neurological outcome
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5945965/
https://www.ncbi.nlm.nih.gov/pubmed/29761127
http://dx.doi.org/10.1002/acn3.561
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