Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances

If misregulated, macrophage (Mϕ)–T cell interactions can drive chronic inflammation thereby causing diseases, such as rheumatoid arthritis (RA). We report that in a proinflammatory environment, granulocyte-Mϕ (GM-CSF)- and Mϕ colony-stimulating factor (M-CSF)-dependent Mϕs have dichotomous effects o...

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Detalles Bibliográficos
Autores principales: Ohradanova-Repic, Anna, Machacek, Christian, Charvet, Celine, Lager, Franck, Le Roux, Delphine, Platzer, René, Leksa, Vladimir, Mitulovic, Goran, Burkard, Thomas R., Zlabinger, Gerhard J., Fischer, Michael B., Feuillet, Vincent, Renault, Gilles, Blüml, Stephan, Benko, Miroslav, Suchanek, Miloslav, Huppa, Johannes B., Matsuyama, Takami, Cavaco-Paulo, Artur, Bismuth, Georges, Stockinger, Hannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946032/
https://www.ncbi.nlm.nih.gov/pubmed/29780382
http://dx.doi.org/10.3389/fimmu.2018.00852

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