Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver

Increasing evidence suggests that regulation of heterochromatin at the nuclear envelope underlies metabolic disease susceptibility and age‐dependent metabolic changes, but the mechanism is unknown. Here, we profile lamina‐associated domains (LADs) using lamin B1 ChIP‐Seq in young and old hepatocytes...

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Detalles Bibliográficos
Autores principales: Whitton, Holly, Singh, Larry N., Patrick, Marissa A., Price, Andrew J., Osorio, Fernando G., López‐Otín, Carlos, Bochkis, Irina M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946061/
https://www.ncbi.nlm.nih.gov/pubmed/29484800
http://dx.doi.org/10.1111/acel.12742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946061/
https://www.ncbi.nlm.nih.gov/pubmed/29484800
http://dx.doi.org/10.1111/acel.12742

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