Cargando…

Changes at the nuclear lamina alter binding of pioneer factor Foxa2 in aged liver

Increasing evidence suggests that regulation of heterochromatin at the nuclear envelope underlies metabolic disease susceptibility and age‐dependent metabolic changes, but the mechanism is unknown. Here, we profile lamina‐associated domains (LADs) using lamin B1 ChIP‐Seq in young and old hepatocytes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Whitton, Holly, Singh, Larry N., Patrick, Marissa A., Price, Andrew J., Osorio, Fernando G., López‐Otín, Carlos, Bochkis, Irina M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946061/ https://www.ncbi.nlm.nih.gov/pubmed/29484800 http://dx.doi.org/10.1111/acel.12742

Ejemplares similares

Redistribution of lamina-associated domains reshapes binding of pioneer factor FOXA2 in development of nonalcoholic fatty liver disease
por: Wei, Xiaolong, et al.
Publicado: (2022)

Pioneer factor Foxa2 enables ligand-dependent activation of type II nuclear receptors FXR and LXRα
por: Kain, Jessica, et al.
Publicado: (2021)

OR33-06 Pioneer Factor Foxa2 Mediates Chromatin Conformation Changes In Ligand-dependent Activation Of FXR
por: Hao, Yi, et al.
Publicado: (2023)

FOXA1: A Pioneer of Nuclear Receptor Action in Breast Cancer
por: Seachrist, Darcie D., et al.
Publicado: (2021)

FOXA1 mutations alter pioneering activity, differentiation, and prostate cancer phenotypes
por: Adams, Elizabeth J., et al.
Publicado: (2019)

Genome-Wide Location Analysis Reveals Distinct Transcriptional Circuitry by Paralogous Regulators Foxa1 and Foxa2
por: Bochkis, Irina M., et al.
Publicado: (2012)

Bookmarking by specific and nonspecific binding of FoxA1 pioneer factor to mitotic chromosomes
por: Caravaca, Juan Manuel, et al.
Publicado: (2013)

Pre-marked chromatin and transcription factor co-binding shape the pioneering activity of Foxa2
por: Cernilogar, Filippo M, et al.
Publicado: (2019)

Pioneer of prostate cancer: past, present and the future of FOXA1
por: Teng, Mona, et al.
Publicado: (2020)

Systematic Dissection of Sequence Features Affecting the Binding Specificity of a Pioneer Factor Reveals Binding Synergy Between FOXA1 and AP-1
por: Xu, Cheng, et al.
Publicado: (2023)

Pioneer Factors FOXA1 and FOXA2 Assist Selective Glucocorticoid Receptor Signaling in Human Endometrial Cells
por: Whirledge, Shannon, et al.
Publicado: (2017)

Genome-wide analysis reveals positional-nucleosome-oriented binding pattern of pioneer factor FOXA1
por: Ye, Zhenqing, et al.
Publicado: (2016)

The pioneer transcription factors Foxa1 and Foxa2 regulate alternative RNA splicing during thymocyte positive selection
por: Lau, Ching-In, et al.
Publicado: (2021)

Pioneer transcription factor FoxA is positioned on hypersensitive nucleosomes at active enhancers
por: Iwafuchi-Doi, Makiko, et al.
Publicado: (2013)

Comprehensive Genomic Analysis Reveals that the Pioneering Function of FOXA1 Is Independent of Hormonal Signaling
por: Glont, Silvia-E., et al.
Publicado: (2019)

A quantitative metric of pioneer activity reveals that HNF4A has stronger in vivo pioneer activity than FOXA1
por: Hansen, Jeffrey L., et al.
Publicado: (2022)

Analyses of an epigenetic switch involved in the activation of pioneer factor FOXA1 leading to the prognostic value of estrogen receptor and FOXA1 co-expression in breast cancer
por: Jing, Xuan, et al.
Publicado: (2019)

The isolation of the nuclear lamina
por: Leslie, Mitch
Publicado: (2005)

The Pioneer Transcription Factor Foxa2 Modulates T Helper Differentiation to Reduce Mouse Allergic Airway Disease
por: Yánez, Diana C., et al.
Publicado: (2022)

Mapping the micro-proteome of the nuclear lamina and lamina-associated domains
por: Wong, Xianrong, et al.
Publicado: (2021)

Similarities between the Epstein-Barr Virus (EBV) Nuclear Protein EBNA1 and the Pioneer Transcription Factor FoxA: Is EBNA1 a “Bookmarking” Oncoprotein that Alters the Host Cell Epigenotype?
por: Niller, Hans Helmut, et al.
Publicado: (2012)

The nuclear lamina in health and disease
por: Dobrzynska, Agnieszka, et al.
Publicado: (2016)

The intriguing plant nuclear lamina
por: Ciska, Malgorzata, et al.
Publicado: (2014)

Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors
por: Geusz, Ryan J., et al.
Publicado: (2021)

Different chromatin-scanning modes lead to targeting of compacted chromatin by pioneer factors FOXA1 and SOX2
por: Lerner, Jonathan, et al.
Publicado: (2023)

Reorganization of the nuclear lamina and cytoskeleton in adipogenesis
por: Verstraeten, Valerie L. R. M., et al.
Publicado: (2011)

Autophagy mediates degradation of nuclear lamina
por: Dou, Zhixun, et al.
Publicado: (2015)

The nuclear lamina during human spermiogenesis
por: Mitchell, Michael
Publicado: (2015)

The Nuclear Lamina as an Organizer of Chromosome Architecture
por: Shevelyov, Yuri Y., et al.
Publicado: (2019)

Defective Nuclear Lamina in Aneuploidy and Carcinogenesis
por: Smith, Elizabeth R., et al.
Publicado: (2018)

The Nuclear Lamina: Protein Accumulation and Disease
por: Almendáriz-Palacios, Carla, et al.
Publicado: (2020)

The nuclear lamina is a hub for the nuclear function of Jacob
por: Samer, Sebastian, et al.
Publicado: (2021)

Interactions of Chromatin with the Nuclear Lamina and Nuclear Pore Complexes
por: Shevelyov, Yuri Y.
Publicado: (2023)

High-Throughput RNA FISH Analysis by Imaging Flow Cytometry Reveals That Pioneer Factor Foxa1 Reduces Transcriptional Stochasticity
por: Lalmansingh, Avin S., et al.
Publicado: (2013)

CRISPR‐based knock‐in mutagenesis of the pioneer transcription factor FOXA1: optimization of strategies for multi‐allelic proteins in cancer cells
por: Li, Shen, et al.
Publicado: (2021)

The nuclear lamina binds the EBV genome during latency and regulates viral gene expression
por: Caruso, Lisa Beatrice, et al.
Publicado: (2022)

Fred Hoyle: pioneer in nuclear astrophysics
Publicado: (2005)

Role of the Nuclear Lamina in Age-Associated Nuclear Reorganization and Inflammation
por: Kristiani, Lidya, et al.
Publicado: (2020)

Baculovirus infection induces disruption of the nuclear lamina
por: Zhang, Xiaomei, et al.
Publicado: (2017)

Structural and Mechanical Aberrations of the Nuclear Lamina in Disease
por: Stiekema, Merel, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_g449bdsls6qap1jt4ronqvnrih