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nNOS–CAPON interaction mediates amyloid‐β‐induced neurotoxicity, especially in the early stages

In neurons, increased protein–protein interactions between neuronal nitric oxide synthase (nNOS) and its carboxy‐terminal PDZ ligand (CAPON) contribute to excitotoxicity and abnormal dendritic spine development, both of which are involved in the development of Alzheimer's disease. In models of...

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Detalles Bibliográficos
Autores principales: Zhang, Yu, Zhu, Zhu, Liang, Hai‐Ying, Zhang, Lei, Zhou, Qi‐Gang, Ni, Huan‐Yu, Luo, Chun‐Xia, Zhu, Dong‐Ya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946066/
https://www.ncbi.nlm.nih.gov/pubmed/29577585
http://dx.doi.org/10.1111/acel.12754