Increasing autophagy and blocking Nrf2 suppress laminopathy‐induced age‐dependent cardiac dysfunction and shortened lifespan

Mutations in the human LMNA gene cause a collection of diseases known as laminopathies. These include myocardial diseases that exhibit age‐dependent penetrance of dysrhythmias and heart failure. The LMNA gene encodes A‐type lamins, intermediate filaments that support nuclear structure and organize t...

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Detalles Bibliográficos
Autores principales: Bhide, Shruti, Trujillo, Adriana S., O'Connor, Maureen T., Young, Grant H., Cryderman, Diane E., Chandran, Sahaana, Nikravesh, Mastaneh, Wallrath, Lori L., Melkani, Girish C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946079/
https://www.ncbi.nlm.nih.gov/pubmed/29575479
http://dx.doi.org/10.1111/acel.12747

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