Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective

The blood–brain barrier (BBB) is a critical biological structure that prevents damage to the brain and maintains its bathing microenvironment. However, this barrier is also the obstacle to deliver beneficial drugs to treat CNS (central nervous system) diseases. Many efforts have been made for improv...

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Detalles Bibliográficos
Autores principales: He, Quanguo, Liu, Jun, Liang, Jing, Liu, Xiaopeng, Li, Wen, Liu, Zhi, Ding, Ziyu, Tuo, Du
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946101/
https://www.ncbi.nlm.nih.gov/pubmed/29570659
http://dx.doi.org/10.3390/cells7040024
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author He, Quanguo
Liu, Jun
Liang, Jing
Liu, Xiaopeng
Li, Wen
Liu, Zhi
Ding, Ziyu
Tuo, Du
author_facet He, Quanguo
Liu, Jun
Liang, Jing
Liu, Xiaopeng
Li, Wen
Liu, Zhi
Ding, Ziyu
Tuo, Du
author_sort He, Quanguo
collection PubMed
description The blood–brain barrier (BBB) is a critical biological structure that prevents damage to the brain and maintains its bathing microenvironment. However, this barrier is also the obstacle to deliver beneficial drugs to treat CNS (central nervous system) diseases. Many efforts have been made for improvement of delivering drugs across the BBB in recent years to treat CNS diseases. In this review, the anatomical and functional structure of the BBB is comprehensively discussed. The mechanisms of BBB penetration are summarized, and the methods and effects on increasing BBB permeability are investigated in detail. It also elaborates on the physical, chemical, biological and nanocarrier aspects to improve drug delivery penetration to the brain and introduces some specific drug delivery effects on BBB permeability.
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spelling pubmed-59461012018-05-15 Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective He, Quanguo Liu, Jun Liang, Jing Liu, Xiaopeng Li, Wen Liu, Zhi Ding, Ziyu Tuo, Du Cells Review The blood–brain barrier (BBB) is a critical biological structure that prevents damage to the brain and maintains its bathing microenvironment. However, this barrier is also the obstacle to deliver beneficial drugs to treat CNS (central nervous system) diseases. Many efforts have been made for improvement of delivering drugs across the BBB in recent years to treat CNS diseases. In this review, the anatomical and functional structure of the BBB is comprehensively discussed. The mechanisms of BBB penetration are summarized, and the methods and effects on increasing BBB permeability are investigated in detail. It also elaborates on the physical, chemical, biological and nanocarrier aspects to improve drug delivery penetration to the brain and introduces some specific drug delivery effects on BBB permeability. MDPI 2018-03-23 /pmc/articles/PMC5946101/ /pubmed/29570659 http://dx.doi.org/10.3390/cells7040024 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
He, Quanguo
Liu, Jun
Liang, Jing
Liu, Xiaopeng
Li, Wen
Liu, Zhi
Ding, Ziyu
Tuo, Du
Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective
title Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective
title_full Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective
title_fullStr Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective
title_full_unstemmed Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective
title_short Towards Improvements for Penetrating the Blood–Brain Barrier—Recent Progress from a Material and Pharmaceutical Perspective
title_sort towards improvements for penetrating the blood–brain barrier—recent progress from a material and pharmaceutical perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946101/
https://www.ncbi.nlm.nih.gov/pubmed/29570659
http://dx.doi.org/10.3390/cells7040024
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