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Milling the Mistletoe: Nanotechnological Conversion of African Mistletoe (Loranthus micranthus) Intoantimicrobial Materials
Nanosizing represents a straight forward technique to unlock the biological activity of complex plant materials. The aim of this study was to develop herbal nanoparticles with medicinal value from dried leaves and stems of Loranthus micranthus with the aid of ball-milling, high speed stirring, and h...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946126/ https://www.ncbi.nlm.nih.gov/pubmed/29677095 http://dx.doi.org/10.3390/antiox7040060 |
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author | Sarfraz, Muhammad Griffin, Sharoon Gabour Sad, Tamara Alhasan, Rama Nasim, Muhammad Jawad Irfan Masood, Muhammad Schäfer, Karl Herbert Ejike, Chukwunonso E.C.C. Keck, Cornelia M. Jacob, Claus Ebokaiwe, Azubuike P. |
author_facet | Sarfraz, Muhammad Griffin, Sharoon Gabour Sad, Tamara Alhasan, Rama Nasim, Muhammad Jawad Irfan Masood, Muhammad Schäfer, Karl Herbert Ejike, Chukwunonso E.C.C. Keck, Cornelia M. Jacob, Claus Ebokaiwe, Azubuike P. |
author_sort | Sarfraz, Muhammad |
collection | PubMed |
description | Nanosizing represents a straight forward technique to unlock the biological activity of complex plant materials. The aim of this study was to develop herbal nanoparticles with medicinal value from dried leaves and stems of Loranthus micranthus with the aid of ball-milling, high speed stirring, and high-pressure homogenization techniques. The milled nanoparticles were characterized using laser diffraction analysis, photon correlation spectroscopy analysis, and light microscopy. The average size of leaf nanoparticles was around 245 nm and that of stem nanoparticles was around 180 nm. The nanoparticles were tested for their antimicrobial and nematicidal properties against a Gram-negative bacterium Escherichia coli, a Gram-positive bacterium Staphylococcus carnosus, fungi Candida albicans and Saccharomyces cerevisiae, and a nematode Steinernemafeltiae. The results show significant activities for both leaf and (particularly) stem nanoparticles of Loranthus micranthus on all organisms tested, even at a particle concentration as low as 0.01% (w/w). The results observed indicate that nanoparticles (especially of the stem) of Loranthus micranthus could serve as novel antimicrobial agents with wide-ranging biomedical applications. |
format | Online Article Text |
id | pubmed-5946126 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59461262018-05-15 Milling the Mistletoe: Nanotechnological Conversion of African Mistletoe (Loranthus micranthus) Intoantimicrobial Materials Sarfraz, Muhammad Griffin, Sharoon Gabour Sad, Tamara Alhasan, Rama Nasim, Muhammad Jawad Irfan Masood, Muhammad Schäfer, Karl Herbert Ejike, Chukwunonso E.C.C. Keck, Cornelia M. Jacob, Claus Ebokaiwe, Azubuike P. Antioxidants (Basel) Article Nanosizing represents a straight forward technique to unlock the biological activity of complex plant materials. The aim of this study was to develop herbal nanoparticles with medicinal value from dried leaves and stems of Loranthus micranthus with the aid of ball-milling, high speed stirring, and high-pressure homogenization techniques. The milled nanoparticles were characterized using laser diffraction analysis, photon correlation spectroscopy analysis, and light microscopy. The average size of leaf nanoparticles was around 245 nm and that of stem nanoparticles was around 180 nm. The nanoparticles were tested for their antimicrobial and nematicidal properties against a Gram-negative bacterium Escherichia coli, a Gram-positive bacterium Staphylococcus carnosus, fungi Candida albicans and Saccharomyces cerevisiae, and a nematode Steinernemafeltiae. The results show significant activities for both leaf and (particularly) stem nanoparticles of Loranthus micranthus on all organisms tested, even at a particle concentration as low as 0.01% (w/w). The results observed indicate that nanoparticles (especially of the stem) of Loranthus micranthus could serve as novel antimicrobial agents with wide-ranging biomedical applications. MDPI 2018-04-20 /pmc/articles/PMC5946126/ /pubmed/29677095 http://dx.doi.org/10.3390/antiox7040060 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Sarfraz, Muhammad Griffin, Sharoon Gabour Sad, Tamara Alhasan, Rama Nasim, Muhammad Jawad Irfan Masood, Muhammad Schäfer, Karl Herbert Ejike, Chukwunonso E.C.C. Keck, Cornelia M. Jacob, Claus Ebokaiwe, Azubuike P. Milling the Mistletoe: Nanotechnological Conversion of African Mistletoe (Loranthus micranthus) Intoantimicrobial Materials |
title | Milling the Mistletoe: Nanotechnological Conversion of African Mistletoe (Loranthus micranthus) Intoantimicrobial Materials |
title_full | Milling the Mistletoe: Nanotechnological Conversion of African Mistletoe (Loranthus micranthus) Intoantimicrobial Materials |
title_fullStr | Milling the Mistletoe: Nanotechnological Conversion of African Mistletoe (Loranthus micranthus) Intoantimicrobial Materials |
title_full_unstemmed | Milling the Mistletoe: Nanotechnological Conversion of African Mistletoe (Loranthus micranthus) Intoantimicrobial Materials |
title_short | Milling the Mistletoe: Nanotechnological Conversion of African Mistletoe (Loranthus micranthus) Intoantimicrobial Materials |
title_sort | milling the mistletoe: nanotechnological conversion of african mistletoe (loranthus micranthus) intoantimicrobial materials |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946126/ https://www.ncbi.nlm.nih.gov/pubmed/29677095 http://dx.doi.org/10.3390/antiox7040060 |
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