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Milling the Mistletoe: Nanotechnological Conversion of African Mistletoe (Loranthus micranthus) Intoantimicrobial Materials

Nanosizing represents a straight forward technique to unlock the biological activity of complex plant materials. The aim of this study was to develop herbal nanoparticles with medicinal value from dried leaves and stems of Loranthus micranthus with the aid of ball-milling, high speed stirring, and h...

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Autores principales: Sarfraz, Muhammad, Griffin, Sharoon, Gabour Sad, Tamara, Alhasan, Rama, Nasim, Muhammad Jawad, Irfan Masood, Muhammad, Schäfer, Karl Herbert, Ejike, Chukwunonso E.C.C., Keck, Cornelia M., Jacob, Claus, Ebokaiwe, Azubuike P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946126/
https://www.ncbi.nlm.nih.gov/pubmed/29677095
http://dx.doi.org/10.3390/antiox7040060
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author Sarfraz, Muhammad
Griffin, Sharoon
Gabour Sad, Tamara
Alhasan, Rama
Nasim, Muhammad Jawad
Irfan Masood, Muhammad
Schäfer, Karl Herbert
Ejike, Chukwunonso E.C.C.
Keck, Cornelia M.
Jacob, Claus
Ebokaiwe, Azubuike P.
author_facet Sarfraz, Muhammad
Griffin, Sharoon
Gabour Sad, Tamara
Alhasan, Rama
Nasim, Muhammad Jawad
Irfan Masood, Muhammad
Schäfer, Karl Herbert
Ejike, Chukwunonso E.C.C.
Keck, Cornelia M.
Jacob, Claus
Ebokaiwe, Azubuike P.
author_sort Sarfraz, Muhammad
collection PubMed
description Nanosizing represents a straight forward technique to unlock the biological activity of complex plant materials. The aim of this study was to develop herbal nanoparticles with medicinal value from dried leaves and stems of Loranthus micranthus with the aid of ball-milling, high speed stirring, and high-pressure homogenization techniques. The milled nanoparticles were characterized using laser diffraction analysis, photon correlation spectroscopy analysis, and light microscopy. The average size of leaf nanoparticles was around 245 nm and that of stem nanoparticles was around 180 nm. The nanoparticles were tested for their antimicrobial and nematicidal properties against a Gram-negative bacterium Escherichia coli, a Gram-positive bacterium Staphylococcus carnosus, fungi Candida albicans and Saccharomyces cerevisiae, and a nematode Steinernemafeltiae. The results show significant activities for both leaf and (particularly) stem nanoparticles of Loranthus micranthus on all organisms tested, even at a particle concentration as low as 0.01% (w/w). The results observed indicate that nanoparticles (especially of the stem) of Loranthus micranthus could serve as novel antimicrobial agents with wide-ranging biomedical applications.
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spelling pubmed-59461262018-05-15 Milling the Mistletoe: Nanotechnological Conversion of African Mistletoe (Loranthus micranthus) Intoantimicrobial Materials Sarfraz, Muhammad Griffin, Sharoon Gabour Sad, Tamara Alhasan, Rama Nasim, Muhammad Jawad Irfan Masood, Muhammad Schäfer, Karl Herbert Ejike, Chukwunonso E.C.C. Keck, Cornelia M. Jacob, Claus Ebokaiwe, Azubuike P. Antioxidants (Basel) Article Nanosizing represents a straight forward technique to unlock the biological activity of complex plant materials. The aim of this study was to develop herbal nanoparticles with medicinal value from dried leaves and stems of Loranthus micranthus with the aid of ball-milling, high speed stirring, and high-pressure homogenization techniques. The milled nanoparticles were characterized using laser diffraction analysis, photon correlation spectroscopy analysis, and light microscopy. The average size of leaf nanoparticles was around 245 nm and that of stem nanoparticles was around 180 nm. The nanoparticles were tested for their antimicrobial and nematicidal properties against a Gram-negative bacterium Escherichia coli, a Gram-positive bacterium Staphylococcus carnosus, fungi Candida albicans and Saccharomyces cerevisiae, and a nematode Steinernemafeltiae. The results show significant activities for both leaf and (particularly) stem nanoparticles of Loranthus micranthus on all organisms tested, even at a particle concentration as low as 0.01% (w/w). The results observed indicate that nanoparticles (especially of the stem) of Loranthus micranthus could serve as novel antimicrobial agents with wide-ranging biomedical applications. MDPI 2018-04-20 /pmc/articles/PMC5946126/ /pubmed/29677095 http://dx.doi.org/10.3390/antiox7040060 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sarfraz, Muhammad
Griffin, Sharoon
Gabour Sad, Tamara
Alhasan, Rama
Nasim, Muhammad Jawad
Irfan Masood, Muhammad
Schäfer, Karl Herbert
Ejike, Chukwunonso E.C.C.
Keck, Cornelia M.
Jacob, Claus
Ebokaiwe, Azubuike P.
Milling the Mistletoe: Nanotechnological Conversion of African Mistletoe (Loranthus micranthus) Intoantimicrobial Materials
title Milling the Mistletoe: Nanotechnological Conversion of African Mistletoe (Loranthus micranthus) Intoantimicrobial Materials
title_full Milling the Mistletoe: Nanotechnological Conversion of African Mistletoe (Loranthus micranthus) Intoantimicrobial Materials
title_fullStr Milling the Mistletoe: Nanotechnological Conversion of African Mistletoe (Loranthus micranthus) Intoantimicrobial Materials
title_full_unstemmed Milling the Mistletoe: Nanotechnological Conversion of African Mistletoe (Loranthus micranthus) Intoantimicrobial Materials
title_short Milling the Mistletoe: Nanotechnological Conversion of African Mistletoe (Loranthus micranthus) Intoantimicrobial Materials
title_sort milling the mistletoe: nanotechnological conversion of african mistletoe (loranthus micranthus) intoantimicrobial materials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946126/
https://www.ncbi.nlm.nih.gov/pubmed/29677095
http://dx.doi.org/10.3390/antiox7040060
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