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Dietary Niacin and Open-Angle Glaucoma: The Korean National Health and Nutrition Examination Survey

Glaucoma is a leading cause of loss of sight. High intraocular pressure (IOP) is the most critical risk factor. However, glaucoma develops even within a normal IOP range. Normal tension glaucoma (NTG) is more common in Asia, whereas high tension glaucoma is more common in Western countries. The path...

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Autores principales: Jung, Kyoung In, Kim, Yong Chan, Park, Chan Kee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946172/
https://www.ncbi.nlm.nih.gov/pubmed/29565276
http://dx.doi.org/10.3390/nu10040387
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author Jung, Kyoung In
Kim, Yong Chan
Park, Chan Kee
author_facet Jung, Kyoung In
Kim, Yong Chan
Park, Chan Kee
author_sort Jung, Kyoung In
collection PubMed
description Glaucoma is a leading cause of loss of sight. High intraocular pressure (IOP) is the most critical risk factor. However, glaucoma develops even within a normal IOP range. Normal tension glaucoma (NTG) is more common in Asia, whereas high tension glaucoma is more common in Western countries. The pathogenesis of glaucoma, especially NTG, is poorly understood. We evaluated the correlation between dietary nutrient intake and glaucoma using data from subjects ≥40 years old from the ongoing, nationwide, population-based study, the Korean National Health and Nutrition Examination Survey V (2008–2012). Dietary intake was determined using the 24 h recall method. Fiber (g/day), ash (g/day), calcium (mg/day), phosphorus (mg/day), iron (mg/day), sodium (mg/day), potassium (mg/day), β-Carotene (μg/day), retinol (μg/day), vitamin A (μg Retinol Equivalents/day), thiamine (mg/day), riboflavin (mg/day), niacin (mg/day), and vitamin C (mg/day) were included in nutrient intake data. All nutrient intake was divided into quartiles. The mean IOP did not differ according to quartiles from any nutrients (all p > 0.05). After adjusting for age, gender, income status, education level, smoking, alcohol consumption, physical activity, diabetes, hypertension, IOP, and total energy, the intake of niacin was associated with glaucoma (p = 0.013). Among subjects with IOP ≤ 21 mmHg, only niacin was related to glaucoma in a multivariate analysis (p = 0.022). Dietary nutrient intake was associated with open-angle glaucoma independent of IOP. Individuals with NTG showed lower intake of niacin among nutrients. This finding suggests the possibility that proper diet counseling may be another modifiable factor, aside from IOP, particularly among patients with NTG.
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spelling pubmed-59461722018-05-15 Dietary Niacin and Open-Angle Glaucoma: The Korean National Health and Nutrition Examination Survey Jung, Kyoung In Kim, Yong Chan Park, Chan Kee Nutrients Article Glaucoma is a leading cause of loss of sight. High intraocular pressure (IOP) is the most critical risk factor. However, glaucoma develops even within a normal IOP range. Normal tension glaucoma (NTG) is more common in Asia, whereas high tension glaucoma is more common in Western countries. The pathogenesis of glaucoma, especially NTG, is poorly understood. We evaluated the correlation between dietary nutrient intake and glaucoma using data from subjects ≥40 years old from the ongoing, nationwide, population-based study, the Korean National Health and Nutrition Examination Survey V (2008–2012). Dietary intake was determined using the 24 h recall method. Fiber (g/day), ash (g/day), calcium (mg/day), phosphorus (mg/day), iron (mg/day), sodium (mg/day), potassium (mg/day), β-Carotene (μg/day), retinol (μg/day), vitamin A (μg Retinol Equivalents/day), thiamine (mg/day), riboflavin (mg/day), niacin (mg/day), and vitamin C (mg/day) were included in nutrient intake data. All nutrient intake was divided into quartiles. The mean IOP did not differ according to quartiles from any nutrients (all p > 0.05). After adjusting for age, gender, income status, education level, smoking, alcohol consumption, physical activity, diabetes, hypertension, IOP, and total energy, the intake of niacin was associated with glaucoma (p = 0.013). Among subjects with IOP ≤ 21 mmHg, only niacin was related to glaucoma in a multivariate analysis (p = 0.022). Dietary nutrient intake was associated with open-angle glaucoma independent of IOP. Individuals with NTG showed lower intake of niacin among nutrients. This finding suggests the possibility that proper diet counseling may be another modifiable factor, aside from IOP, particularly among patients with NTG. MDPI 2018-03-22 /pmc/articles/PMC5946172/ /pubmed/29565276 http://dx.doi.org/10.3390/nu10040387 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jung, Kyoung In
Kim, Yong Chan
Park, Chan Kee
Dietary Niacin and Open-Angle Glaucoma: The Korean National Health and Nutrition Examination Survey
title Dietary Niacin and Open-Angle Glaucoma: The Korean National Health and Nutrition Examination Survey
title_full Dietary Niacin and Open-Angle Glaucoma: The Korean National Health and Nutrition Examination Survey
title_fullStr Dietary Niacin and Open-Angle Glaucoma: The Korean National Health and Nutrition Examination Survey
title_full_unstemmed Dietary Niacin and Open-Angle Glaucoma: The Korean National Health and Nutrition Examination Survey
title_short Dietary Niacin and Open-Angle Glaucoma: The Korean National Health and Nutrition Examination Survey
title_sort dietary niacin and open-angle glaucoma: the korean national health and nutrition examination survey
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946172/
https://www.ncbi.nlm.nih.gov/pubmed/29565276
http://dx.doi.org/10.3390/nu10040387
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