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Dietary Flavonoids in the Prevention of T2D: An Overview
Type 2 diabetes (T2D) is a progressive metabolic disease that is increasing in prevalence globally. It is well established that insulin resistance (IR) and a progressive decline in functional β-cell mass are hallmarks of developing T2D. Obesity is a leading pathogenic factor for developing IR. Const...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946223/ https://www.ncbi.nlm.nih.gov/pubmed/29614722 http://dx.doi.org/10.3390/nu10040438 |
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author | Alkhalidy, Hana Wang, Yao Liu, Dongmin |
author_facet | Alkhalidy, Hana Wang, Yao Liu, Dongmin |
author_sort | Alkhalidy, Hana |
collection | PubMed |
description | Type 2 diabetes (T2D) is a progressive metabolic disease that is increasing in prevalence globally. It is well established that insulin resistance (IR) and a progressive decline in functional β-cell mass are hallmarks of developing T2D. Obesity is a leading pathogenic factor for developing IR. Constant IR will progress to T2D when β-cells are unable to secret adequate amounts of insulin to compensate for decreased insulin sensitivity. Recently, a considerable amount of research has been devoted to identifying naturally occurring anti-diabetic compounds that are abundant in certain types of foods. Flavonoids are a group of polyphenols that have drawn great interest for their various health benefits. Results from many clinical and animal studies demonstrate that dietary intake of flavonoids might be helpful in preventing T2D, although cellular and molecular mechanisms underlying these effects are still not completely understood. This review discusses our current understanding of the pathophysiology of T2D and highlights the potential anti-diabetic effects of flavonoids and mechanisms of their actions. |
format | Online Article Text |
id | pubmed-5946223 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59462232018-05-15 Dietary Flavonoids in the Prevention of T2D: An Overview Alkhalidy, Hana Wang, Yao Liu, Dongmin Nutrients Review Type 2 diabetes (T2D) is a progressive metabolic disease that is increasing in prevalence globally. It is well established that insulin resistance (IR) and a progressive decline in functional β-cell mass are hallmarks of developing T2D. Obesity is a leading pathogenic factor for developing IR. Constant IR will progress to T2D when β-cells are unable to secret adequate amounts of insulin to compensate for decreased insulin sensitivity. Recently, a considerable amount of research has been devoted to identifying naturally occurring anti-diabetic compounds that are abundant in certain types of foods. Flavonoids are a group of polyphenols that have drawn great interest for their various health benefits. Results from many clinical and animal studies demonstrate that dietary intake of flavonoids might be helpful in preventing T2D, although cellular and molecular mechanisms underlying these effects are still not completely understood. This review discusses our current understanding of the pathophysiology of T2D and highlights the potential anti-diabetic effects of flavonoids and mechanisms of their actions. MDPI 2018-03-31 /pmc/articles/PMC5946223/ /pubmed/29614722 http://dx.doi.org/10.3390/nu10040438 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Alkhalidy, Hana Wang, Yao Liu, Dongmin Dietary Flavonoids in the Prevention of T2D: An Overview |
title | Dietary Flavonoids in the Prevention of T2D: An Overview |
title_full | Dietary Flavonoids in the Prevention of T2D: An Overview |
title_fullStr | Dietary Flavonoids in the Prevention of T2D: An Overview |
title_full_unstemmed | Dietary Flavonoids in the Prevention of T2D: An Overview |
title_short | Dietary Flavonoids in the Prevention of T2D: An Overview |
title_sort | dietary flavonoids in the prevention of t2d: an overview |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946223/ https://www.ncbi.nlm.nih.gov/pubmed/29614722 http://dx.doi.org/10.3390/nu10040438 |
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