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Folate and B12 Levels Correlate with Histological Severity in NASH Patients

Background: The correlation between abnormal vitamin serum levels and chronic liver disease has been previously described in literature. However, the association between the severity of folate serum levels (B9), vitamin B12 and nonalcoholic steatohepatitis (NASH) has not been widely evaluated. There...

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Autores principales: Mahamid, Mahmud, Mahroum, Naim, Bragazzi, Nicola Luigi, Shalaata, Kasem, Yavne, Yarden, Adawi, Mohammad, Amital, Howard, Watad, Abdulla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946225/
https://www.ncbi.nlm.nih.gov/pubmed/29614799
http://dx.doi.org/10.3390/nu10040440
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author Mahamid, Mahmud
Mahroum, Naim
Bragazzi, Nicola Luigi
Shalaata, Kasem
Yavne, Yarden
Adawi, Mohammad
Amital, Howard
Watad, Abdulla
author_facet Mahamid, Mahmud
Mahroum, Naim
Bragazzi, Nicola Luigi
Shalaata, Kasem
Yavne, Yarden
Adawi, Mohammad
Amital, Howard
Watad, Abdulla
author_sort Mahamid, Mahmud
collection PubMed
description Background: The correlation between abnormal vitamin serum levels and chronic liver disease has been previously described in literature. However, the association between the severity of folate serum levels (B9), vitamin B12 and nonalcoholic steatohepatitis (NASH) has not been widely evaluated. Therefore, the aim of this study was to investigate the existence of such a correlation in a cohort of NASH patients. Methods: All patients aged 18 years and older who were diagnosed with biopsy-proven NASH at the EMMS hospital in Nazareth during the years 2015–2017 were enrolled in this study. Data regarding demographic, clinical and laboratory parameters was collected. Patients with other liver diseases were excluded. Results: Eighty-three NASH patients were enrolled during the study period. The mean age was 41 ± 11 years and the majority of patients were male. Mean values of folate and B12 were 9.85 ± 10.90 ng/mL and 387.53 ± 205.50 pg/mL, respectively. Half of the patients were presented with a grade 1 steatosis (43.4%), a grade 2 fibrosis (50.6%) and a grade 3 activity score (55.4%). The fibrosis grade was significantly correlated with low folate levels on multivariate analysis (p-value < 0.01). Similarly, low B12 levels were significantly associated with a higher fibrosis grade and NASH activity (p-value < 0.001 and p-value < 0.05 respectively). Conclusion: Our study demonstrated a statistically significant correlation between low levels of folate and vitamin B12 with the histological severity of NASH. These findings could have diagnostic and therapeutic implications for patient management and follow-up.
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spelling pubmed-59462252018-05-15 Folate and B12 Levels Correlate with Histological Severity in NASH Patients Mahamid, Mahmud Mahroum, Naim Bragazzi, Nicola Luigi Shalaata, Kasem Yavne, Yarden Adawi, Mohammad Amital, Howard Watad, Abdulla Nutrients Article Background: The correlation between abnormal vitamin serum levels and chronic liver disease has been previously described in literature. However, the association between the severity of folate serum levels (B9), vitamin B12 and nonalcoholic steatohepatitis (NASH) has not been widely evaluated. Therefore, the aim of this study was to investigate the existence of such a correlation in a cohort of NASH patients. Methods: All patients aged 18 years and older who were diagnosed with biopsy-proven NASH at the EMMS hospital in Nazareth during the years 2015–2017 were enrolled in this study. Data regarding demographic, clinical and laboratory parameters was collected. Patients with other liver diseases were excluded. Results: Eighty-three NASH patients were enrolled during the study period. The mean age was 41 ± 11 years and the majority of patients were male. Mean values of folate and B12 were 9.85 ± 10.90 ng/mL and 387.53 ± 205.50 pg/mL, respectively. Half of the patients were presented with a grade 1 steatosis (43.4%), a grade 2 fibrosis (50.6%) and a grade 3 activity score (55.4%). The fibrosis grade was significantly correlated with low folate levels on multivariate analysis (p-value < 0.01). Similarly, low B12 levels were significantly associated with a higher fibrosis grade and NASH activity (p-value < 0.001 and p-value < 0.05 respectively). Conclusion: Our study demonstrated a statistically significant correlation between low levels of folate and vitamin B12 with the histological severity of NASH. These findings could have diagnostic and therapeutic implications for patient management and follow-up. MDPI 2018-04-02 /pmc/articles/PMC5946225/ /pubmed/29614799 http://dx.doi.org/10.3390/nu10040440 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mahamid, Mahmud
Mahroum, Naim
Bragazzi, Nicola Luigi
Shalaata, Kasem
Yavne, Yarden
Adawi, Mohammad
Amital, Howard
Watad, Abdulla
Folate and B12 Levels Correlate with Histological Severity in NASH Patients
title Folate and B12 Levels Correlate with Histological Severity in NASH Patients
title_full Folate and B12 Levels Correlate with Histological Severity in NASH Patients
title_fullStr Folate and B12 Levels Correlate with Histological Severity in NASH Patients
title_full_unstemmed Folate and B12 Levels Correlate with Histological Severity in NASH Patients
title_short Folate and B12 Levels Correlate with Histological Severity in NASH Patients
title_sort folate and b12 levels correlate with histological severity in nash patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946225/
https://www.ncbi.nlm.nih.gov/pubmed/29614799
http://dx.doi.org/10.3390/nu10040440
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