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Lutein and Zeaxanthin Are Positively Associated with Visual–Spatial Functioning in Older Adults: An fMRI Study

Lutein (L) and zeaxanthin (Z) are two xanthophyll carotenoids that have antioxidant and anti-inflammatory properties. Previous work has demonstrated their importance for eye health and preventing diseases such as age-related macular degeneration. An emerging literature base has also demonstrated the...

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Autores principales: Mewborn, Catherine M., Lindbergh, Cutter A., Robinson, Talia L., Gogniat, Marissa A., Terry, Douglas P., Jean, Kharine R., Hammond, Billy Randy, Renzi-Hammond, Lisa M., Miller, Lloyd Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946243/
https://www.ncbi.nlm.nih.gov/pubmed/29642425
http://dx.doi.org/10.3390/nu10040458
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author Mewborn, Catherine M.
Lindbergh, Cutter A.
Robinson, Talia L.
Gogniat, Marissa A.
Terry, Douglas P.
Jean, Kharine R.
Hammond, Billy Randy
Renzi-Hammond, Lisa M.
Miller, Lloyd Stephen
author_facet Mewborn, Catherine M.
Lindbergh, Cutter A.
Robinson, Talia L.
Gogniat, Marissa A.
Terry, Douglas P.
Jean, Kharine R.
Hammond, Billy Randy
Renzi-Hammond, Lisa M.
Miller, Lloyd Stephen
author_sort Mewborn, Catherine M.
collection PubMed
description Lutein (L) and zeaxanthin (Z) are two xanthophyll carotenoids that have antioxidant and anti-inflammatory properties. Previous work has demonstrated their importance for eye health and preventing diseases such as age-related macular degeneration. An emerging literature base has also demonstrated the importance of L and Z in cognition, neural structure, and neural efficiency. The present study aimed to better understand the mechanisms by which L and Z relate to cognition, in particular, visual–spatial processing and decision-making in older adults. We hypothesized that markers of higher levels of L and Z would be associated with better neural efficiency during a visual–spatial processing task. L and Z were assessed via standard measurement of blood serum and retinal concentrations. Visual–spatial processing and decision-making were assessed via a judgment of line orientation task (JLO) completed during a functional magnetic resonance imaging (fMRI) scan. The results demonstrated that individuals with higher concentrations of L and Z showed a decreased blood-oxygen-level dependent (BOLD) signal during task performance (i.e., “neural efficiency”) in key areas associated with visual–spatial perception, processing, decision-making, and motor coordination, including the lateral occipital cortex, occipital pole, superior and middle temporal gyri, superior parietal lobule, superior and middle frontal gyri, and pre- and post-central gyri. To our knowledge, this is the first investigation of the relationship of L and Z to visual–spatial processing at a neural level using in vivo methodology. Our findings suggest that L and Z may impact brain health and cognition in older adults by enhancing neurobiological efficiency in a variety of regions that support visual perception and decision-making.
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spelling pubmed-59462432018-05-15 Lutein and Zeaxanthin Are Positively Associated with Visual–Spatial Functioning in Older Adults: An fMRI Study Mewborn, Catherine M. Lindbergh, Cutter A. Robinson, Talia L. Gogniat, Marissa A. Terry, Douglas P. Jean, Kharine R. Hammond, Billy Randy Renzi-Hammond, Lisa M. Miller, Lloyd Stephen Nutrients Article Lutein (L) and zeaxanthin (Z) are two xanthophyll carotenoids that have antioxidant and anti-inflammatory properties. Previous work has demonstrated their importance for eye health and preventing diseases such as age-related macular degeneration. An emerging literature base has also demonstrated the importance of L and Z in cognition, neural structure, and neural efficiency. The present study aimed to better understand the mechanisms by which L and Z relate to cognition, in particular, visual–spatial processing and decision-making in older adults. We hypothesized that markers of higher levels of L and Z would be associated with better neural efficiency during a visual–spatial processing task. L and Z were assessed via standard measurement of blood serum and retinal concentrations. Visual–spatial processing and decision-making were assessed via a judgment of line orientation task (JLO) completed during a functional magnetic resonance imaging (fMRI) scan. The results demonstrated that individuals with higher concentrations of L and Z showed a decreased blood-oxygen-level dependent (BOLD) signal during task performance (i.e., “neural efficiency”) in key areas associated with visual–spatial perception, processing, decision-making, and motor coordination, including the lateral occipital cortex, occipital pole, superior and middle temporal gyri, superior parietal lobule, superior and middle frontal gyri, and pre- and post-central gyri. To our knowledge, this is the first investigation of the relationship of L and Z to visual–spatial processing at a neural level using in vivo methodology. Our findings suggest that L and Z may impact brain health and cognition in older adults by enhancing neurobiological efficiency in a variety of regions that support visual perception and decision-making. MDPI 2018-04-07 /pmc/articles/PMC5946243/ /pubmed/29642425 http://dx.doi.org/10.3390/nu10040458 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mewborn, Catherine M.
Lindbergh, Cutter A.
Robinson, Talia L.
Gogniat, Marissa A.
Terry, Douglas P.
Jean, Kharine R.
Hammond, Billy Randy
Renzi-Hammond, Lisa M.
Miller, Lloyd Stephen
Lutein and Zeaxanthin Are Positively Associated with Visual–Spatial Functioning in Older Adults: An fMRI Study
title Lutein and Zeaxanthin Are Positively Associated with Visual–Spatial Functioning in Older Adults: An fMRI Study
title_full Lutein and Zeaxanthin Are Positively Associated with Visual–Spatial Functioning in Older Adults: An fMRI Study
title_fullStr Lutein and Zeaxanthin Are Positively Associated with Visual–Spatial Functioning in Older Adults: An fMRI Study
title_full_unstemmed Lutein and Zeaxanthin Are Positively Associated with Visual–Spatial Functioning in Older Adults: An fMRI Study
title_short Lutein and Zeaxanthin Are Positively Associated with Visual–Spatial Functioning in Older Adults: An fMRI Study
title_sort lutein and zeaxanthin are positively associated with visual–spatial functioning in older adults: an fmri study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946243/
https://www.ncbi.nlm.nih.gov/pubmed/29642425
http://dx.doi.org/10.3390/nu10040458
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