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Association between Urinary Aflatoxin (AFM(1)) and Dietary Intake among Adults in Hulu Langat District, Selangor, Malaysia

Aflatoxin is a food contaminant and its exposure through the diet is frequent and ubiquitous. A long-term dietary aflatoxin exposure has been linked to the development of liver cancer in populations with high prevalence of aflatoxin contamination in foods. Therefore, this study was conducted to iden...

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Autores principales: Sulaiman, Siti Husna, Jamaluddin, Rosita, Sabran, Mohd Redzwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946245/
https://www.ncbi.nlm.nih.gov/pubmed/29642443
http://dx.doi.org/10.3390/nu10040460
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author Sulaiman, Siti Husna
Jamaluddin, Rosita
Sabran, Mohd Redzwan
author_facet Sulaiman, Siti Husna
Jamaluddin, Rosita
Sabran, Mohd Redzwan
author_sort Sulaiman, Siti Husna
collection PubMed
description Aflatoxin is a food contaminant and its exposure through the diet is frequent and ubiquitous. A long-term dietary aflatoxin exposure has been linked to the development of liver cancer in populations with high prevalence of aflatoxin contamination in foods. Therefore, this study was conducted to identify the association between urinary aflatoxin M(1) (AFM(1)), a biomarker of aflatoxin exposure, with the dietary intake among adults in Hulu Langat district, Selangor, Malaysia. Certain food products have higher potential for aflatoxin contamination and these were listed in a Food Frequency Questionnaire, which was given to all study participants. This allowed us to record consumption rates for each food product listed. Concomitantly, urine samples were collected, from adults in selected areas in Hulu Langat district, for the measurement of AFM(1) levels using an ELISA kit. Of the 444 urine samples collected and tested, 199 were positive for AFM(1), with 37 of them exceeding the limit of detection (LOD) of 0.64 ng/mL. Cereal products showed the highest consumption level among all food groups, with an average intake of 512.54 g per day. Chi-square analysis showed that consumption of eggs (X(2) = 4.77, p = 0.03) and dairy products (X(2) = 19.36, p < 0.01) had significant associations with urinary AFM(1) but both food groups were having a phi and Cramer’s V value that less than 0.3, which indicated that the association between these food groups’ consumption and AFM(1) level in urine was weak.
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spelling pubmed-59462452018-05-15 Association between Urinary Aflatoxin (AFM(1)) and Dietary Intake among Adults in Hulu Langat District, Selangor, Malaysia Sulaiman, Siti Husna Jamaluddin, Rosita Sabran, Mohd Redzwan Nutrients Article Aflatoxin is a food contaminant and its exposure through the diet is frequent and ubiquitous. A long-term dietary aflatoxin exposure has been linked to the development of liver cancer in populations with high prevalence of aflatoxin contamination in foods. Therefore, this study was conducted to identify the association between urinary aflatoxin M(1) (AFM(1)), a biomarker of aflatoxin exposure, with the dietary intake among adults in Hulu Langat district, Selangor, Malaysia. Certain food products have higher potential for aflatoxin contamination and these were listed in a Food Frequency Questionnaire, which was given to all study participants. This allowed us to record consumption rates for each food product listed. Concomitantly, urine samples were collected, from adults in selected areas in Hulu Langat district, for the measurement of AFM(1) levels using an ELISA kit. Of the 444 urine samples collected and tested, 199 were positive for AFM(1), with 37 of them exceeding the limit of detection (LOD) of 0.64 ng/mL. Cereal products showed the highest consumption level among all food groups, with an average intake of 512.54 g per day. Chi-square analysis showed that consumption of eggs (X(2) = 4.77, p = 0.03) and dairy products (X(2) = 19.36, p < 0.01) had significant associations with urinary AFM(1) but both food groups were having a phi and Cramer’s V value that less than 0.3, which indicated that the association between these food groups’ consumption and AFM(1) level in urine was weak. MDPI 2018-04-07 /pmc/articles/PMC5946245/ /pubmed/29642443 http://dx.doi.org/10.3390/nu10040460 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sulaiman, Siti Husna
Jamaluddin, Rosita
Sabran, Mohd Redzwan
Association between Urinary Aflatoxin (AFM(1)) and Dietary Intake among Adults in Hulu Langat District, Selangor, Malaysia
title Association between Urinary Aflatoxin (AFM(1)) and Dietary Intake among Adults in Hulu Langat District, Selangor, Malaysia
title_full Association between Urinary Aflatoxin (AFM(1)) and Dietary Intake among Adults in Hulu Langat District, Selangor, Malaysia
title_fullStr Association between Urinary Aflatoxin (AFM(1)) and Dietary Intake among Adults in Hulu Langat District, Selangor, Malaysia
title_full_unstemmed Association between Urinary Aflatoxin (AFM(1)) and Dietary Intake among Adults in Hulu Langat District, Selangor, Malaysia
title_short Association between Urinary Aflatoxin (AFM(1)) and Dietary Intake among Adults in Hulu Langat District, Selangor, Malaysia
title_sort association between urinary aflatoxin (afm(1)) and dietary intake among adults in hulu langat district, selangor, malaysia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946245/
https://www.ncbi.nlm.nih.gov/pubmed/29642443
http://dx.doi.org/10.3390/nu10040460
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