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Elevated serum levels of malondialdehyde and cortisol are associated with major depressive disorder: A case-control study
OBJECTIVES: Major depressive disorder is diagnosed on the basis of patient’s self-reported experiences, behavior reported by relatives, and a mental status examination, and yet we do not have any reliable biomarker for this. Mood-regulating pathways are affected by oxidative injury to lipids and cor...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946642/ https://www.ncbi.nlm.nih.gov/pubmed/29770218 http://dx.doi.org/10.1177/2050312118773953 |
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author | Islam, Md Rabiul Islam, Md Reazul Ahmed, Imtiaz Moktadir, Abdullah Al Nahar, Zabun Islam, Mohammad Safiqul Shahid, Shelina Fatema Binte Islam, Sheikh Nazrul Islam, Md Saiful Hasnat, Abul |
author_facet | Islam, Md Rabiul Islam, Md Reazul Ahmed, Imtiaz Moktadir, Abdullah Al Nahar, Zabun Islam, Mohammad Safiqul Shahid, Shelina Fatema Binte Islam, Sheikh Nazrul Islam, Md Saiful Hasnat, Abul |
author_sort | Islam, Md Rabiul |
collection | PubMed |
description | OBJECTIVES: Major depressive disorder is diagnosed on the basis of patient’s self-reported experiences, behavior reported by relatives, and a mental status examination, and yet we do not have any reliable biomarker for this. Mood-regulating pathways are affected by oxidative injury to lipids and cortisol is released into the blood due to stimulation of corticotrophin receptors in the adrenal cortex. Here, we aimed to determine serum levels of malondialdehyde and cortisol in major depressive disorder patients and controls. METHODS: We collected blood samples from 247 major depressive disorder patients and 248 controls. Serum levels of malondialdehyde and cortisol were measured by ultraviolet spectrophotometry and enzyme-linked immunosorbent assay kit, respectively. RESULTS: We found malondialdehyde levels were significantly higher in patients than controls, with mean ± standard deviation at 4.49 ± 1.37 and 2.87 ± 0.82 µmol/L, respectively, p < 0.001. Cortisol levels were also found significantly higher in patients than controls, with mean ± SD at 19.22 ± 1.64 and 17.37 ± 1.34 µg/dL, respectively, p < 0.001. Significant negative correlation was observed between serum levels of malondialdehyde and cortisol in patients (r =−0.170, p = 0.021). Receiver operating characteristic analysis showed good diagnostic value for malondialdehyde and cortisol, with the area under the curve at 0.853 and 0.819, respectively. CONCLUSION: The present study suggests that increased serum levels of malondialdehyde and cortisol are strongly associated with major depressive disorder. We believe elevations of malondialdehyde and cortisol in serum level arise independently and they could serve as biomarkers for major depressive disorder. |
format | Online Article Text |
id | pubmed-5946642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-59466422018-05-16 Elevated serum levels of malondialdehyde and cortisol are associated with major depressive disorder: A case-control study Islam, Md Rabiul Islam, Md Reazul Ahmed, Imtiaz Moktadir, Abdullah Al Nahar, Zabun Islam, Mohammad Safiqul Shahid, Shelina Fatema Binte Islam, Sheikh Nazrul Islam, Md Saiful Hasnat, Abul SAGE Open Med Original Article OBJECTIVES: Major depressive disorder is diagnosed on the basis of patient’s self-reported experiences, behavior reported by relatives, and a mental status examination, and yet we do not have any reliable biomarker for this. Mood-regulating pathways are affected by oxidative injury to lipids and cortisol is released into the blood due to stimulation of corticotrophin receptors in the adrenal cortex. Here, we aimed to determine serum levels of malondialdehyde and cortisol in major depressive disorder patients and controls. METHODS: We collected blood samples from 247 major depressive disorder patients and 248 controls. Serum levels of malondialdehyde and cortisol were measured by ultraviolet spectrophotometry and enzyme-linked immunosorbent assay kit, respectively. RESULTS: We found malondialdehyde levels were significantly higher in patients than controls, with mean ± standard deviation at 4.49 ± 1.37 and 2.87 ± 0.82 µmol/L, respectively, p < 0.001. Cortisol levels were also found significantly higher in patients than controls, with mean ± SD at 19.22 ± 1.64 and 17.37 ± 1.34 µg/dL, respectively, p < 0.001. Significant negative correlation was observed between serum levels of malondialdehyde and cortisol in patients (r =−0.170, p = 0.021). Receiver operating characteristic analysis showed good diagnostic value for malondialdehyde and cortisol, with the area under the curve at 0.853 and 0.819, respectively. CONCLUSION: The present study suggests that increased serum levels of malondialdehyde and cortisol are strongly associated with major depressive disorder. We believe elevations of malondialdehyde and cortisol in serum level arise independently and they could serve as biomarkers for major depressive disorder. SAGE Publications 2018-05-09 /pmc/articles/PMC5946642/ /pubmed/29770218 http://dx.doi.org/10.1177/2050312118773953 Text en © The Author(s) 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Article Islam, Md Rabiul Islam, Md Reazul Ahmed, Imtiaz Moktadir, Abdullah Al Nahar, Zabun Islam, Mohammad Safiqul Shahid, Shelina Fatema Binte Islam, Sheikh Nazrul Islam, Md Saiful Hasnat, Abul Elevated serum levels of malondialdehyde and cortisol are associated with major depressive disorder: A case-control study |
title | Elevated serum levels of malondialdehyde and cortisol are associated with major depressive disorder: A case-control study |
title_full | Elevated serum levels of malondialdehyde and cortisol are associated with major depressive disorder: A case-control study |
title_fullStr | Elevated serum levels of malondialdehyde and cortisol are associated with major depressive disorder: A case-control study |
title_full_unstemmed | Elevated serum levels of malondialdehyde and cortisol are associated with major depressive disorder: A case-control study |
title_short | Elevated serum levels of malondialdehyde and cortisol are associated with major depressive disorder: A case-control study |
title_sort | elevated serum levels of malondialdehyde and cortisol are associated with major depressive disorder: a case-control study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946642/ https://www.ncbi.nlm.nih.gov/pubmed/29770218 http://dx.doi.org/10.1177/2050312118773953 |
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