Chronic Granulomatous Disease: Epidemiology, Pathophysiology, and Genetic Basis of Disease

Chronic Granulomatous Disease is one of the classic primary immunodeficiencies of childhood. While the incidence and severity of bacterial and fungal infections have been greatly reduced in this patient population, much remains to be learned about the pathophysiology of the disease, particularly for...

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Detalles Bibliográficos
Autores principales: Rider, N L, Jameson, M B, Creech, C B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Supplement Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946813/
https://www.ncbi.nlm.nih.gov/pubmed/29746675
http://dx.doi.org/10.1093/jpids/piy008
Descripción
Sumario:Chronic Granulomatous Disease is one of the classic primary immunodeficiencies of childhood. While the incidence and severity of bacterial and fungal infections have been greatly reduced in this patient population, much remains to be learned about the pathophysiology of the disease, particularly for autoinflammatory manifestations. In this review, we examine the epidemiology, pathophysiology, and genetic basis for CGD.

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