Chronic Granulomatous Disease: Epidemiology, Pathophysiology, and Genetic Basis of Disease

Chronic Granulomatous Disease is one of the classic primary immunodeficiencies of childhood. While the incidence and severity of bacterial and fungal infections have been greatly reduced in this patient population, much remains to be learned about the pathophysiology of the disease, particularly for...

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Detalles Bibliográficos
Autores principales: Rider, N L, Jameson, M B, Creech, C B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Supplement Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946813/
https://www.ncbi.nlm.nih.gov/pubmed/29746675
http://dx.doi.org/10.1093/jpids/piy008
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author Rider, N L
Jameson, M B
Creech, C B
author_facet Rider, N L
Jameson, M B
Creech, C B
author_sort Rider, N L
collection PubMed
description Chronic Granulomatous Disease is one of the classic primary immunodeficiencies of childhood. While the incidence and severity of bacterial and fungal infections have been greatly reduced in this patient population, much remains to be learned about the pathophysiology of the disease, particularly for autoinflammatory manifestations. In this review, we examine the epidemiology, pathophysiology, and genetic basis for CGD.
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spelling pubmed-59468132018-05-15 Chronic Granulomatous Disease: Epidemiology, Pathophysiology, and Genetic Basis of Disease Rider, N L Jameson, M B Creech, C B J Pediatric Infect Dis Soc Supplement Articles Chronic Granulomatous Disease is one of the classic primary immunodeficiencies of childhood. While the incidence and severity of bacterial and fungal infections have been greatly reduced in this patient population, much remains to be learned about the pathophysiology of the disease, particularly for autoinflammatory manifestations. In this review, we examine the epidemiology, pathophysiology, and genetic basis for CGD. Oxford University Press 2018-05 2018-05-09 /pmc/articles/PMC5946813/ /pubmed/29746675 http://dx.doi.org/10.1093/jpids/piy008 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Supplement Articles
Rider, N L
Jameson, M B
Creech, C B
Chronic Granulomatous Disease: Epidemiology, Pathophysiology, and Genetic Basis of Disease
title Chronic Granulomatous Disease: Epidemiology, Pathophysiology, and Genetic Basis of Disease
title_full Chronic Granulomatous Disease: Epidemiology, Pathophysiology, and Genetic Basis of Disease
title_fullStr Chronic Granulomatous Disease: Epidemiology, Pathophysiology, and Genetic Basis of Disease
title_full_unstemmed Chronic Granulomatous Disease: Epidemiology, Pathophysiology, and Genetic Basis of Disease
title_short Chronic Granulomatous Disease: Epidemiology, Pathophysiology, and Genetic Basis of Disease
title_sort chronic granulomatous disease: epidemiology, pathophysiology, and genetic basis of disease
topic Supplement Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946813/
https://www.ncbi.nlm.nih.gov/pubmed/29746675
http://dx.doi.org/10.1093/jpids/piy008
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