Prevention of Infectious Complications in Patients With Chronic Granulomatous Disease

Chronic granulomatous disease (CGD) is a primary immunodeficiency that confers a markedly increased risk of bacterial and fungal infections caused by certain opportunistic pathogens. Current evidence supports the use of prophylactic antibacterial, antifungal, and immunomodulatory therapies designed...

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Autores principales: Slack, Maria A, Thomsen, Isaac P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Supplement Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946879/
https://www.ncbi.nlm.nih.gov/pubmed/29746681
http://dx.doi.org/10.1093/jpids/piy016
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author Slack, Maria A
Thomsen, Isaac P
author_facet Slack, Maria A
Thomsen, Isaac P
author_sort Slack, Maria A
collection PubMed
description Chronic granulomatous disease (CGD) is a primary immunodeficiency that confers a markedly increased risk of bacterial and fungal infections caused by certain opportunistic pathogens. Current evidence supports the use of prophylactic antibacterial, antifungal, and immunomodulatory therapies designed to prevent serious or life-threatening infections in patients with CGD. In this review, we discuss current strategies for the prevention of infections in children and adults with CGD and the evidence that supports those strategies. In addition, we address current challenges and opportunities for future research in this important area.
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spelling pubmed-59468792018-05-16 Prevention of Infectious Complications in Patients With Chronic Granulomatous Disease Slack, Maria A Thomsen, Isaac P J Pediatric Infect Dis Soc Supplement Articles Chronic granulomatous disease (CGD) is a primary immunodeficiency that confers a markedly increased risk of bacterial and fungal infections caused by certain opportunistic pathogens. Current evidence supports the use of prophylactic antibacterial, antifungal, and immunomodulatory therapies designed to prevent serious or life-threatening infections in patients with CGD. In this review, we discuss current strategies for the prevention of infections in children and adults with CGD and the evidence that supports those strategies. In addition, we address current challenges and opportunities for future research in this important area. Oxford University Press 2018-05 2018-05-09 /pmc/articles/PMC5946879/ /pubmed/29746681 http://dx.doi.org/10.1093/jpids/piy016 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Supplement Articles
Slack, Maria A
Thomsen, Isaac P
Prevention of Infectious Complications in Patients With Chronic Granulomatous Disease
title Prevention of Infectious Complications in Patients With Chronic Granulomatous Disease
title_full Prevention of Infectious Complications in Patients With Chronic Granulomatous Disease
title_fullStr Prevention of Infectious Complications in Patients With Chronic Granulomatous Disease
title_full_unstemmed Prevention of Infectious Complications in Patients With Chronic Granulomatous Disease
title_short Prevention of Infectious Complications in Patients With Chronic Granulomatous Disease
title_sort prevention of infectious complications in patients with chronic granulomatous disease
topic Supplement Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946879/
https://www.ncbi.nlm.nih.gov/pubmed/29746681
http://dx.doi.org/10.1093/jpids/piy016
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