Crystal structures of two new 3-(2-chloro­eth­yl)-r(2),c(6)-diarylpiperidin-4-ones

The syntheses and crystal structures of 3-(2-chloro­eth­yl)-r-2,c-6-di­phenyl­piperidin-4-one, C(19)H(20)ClNO, (I), and 3-(2-chloro­eth­yl)-r-2,c-6-bis­(4-fluoro­phen­yl)piperidin-4-one, C(19)H(18)ClF(2)NO, (II), are described. The piperidone ring adopts a chair conformation in (I), whereas a slight...

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Autores principales: Rajkumar, K., Sivakumar, S., Arulraj, R., Kaur, Manpreet, Jasinski, Jerry P., Manimekalai, A., Thiruvalluvar, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2018
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946973/
https://www.ncbi.nlm.nih.gov/pubmed/29765751
http://dx.doi.org/10.1107/S2056989018003766
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author Rajkumar, K.
Sivakumar, S.
Arulraj, R.
Kaur, Manpreet
Jasinski, Jerry P.
Manimekalai, A.
Thiruvalluvar, A.
author_facet Rajkumar, K.
Sivakumar, S.
Arulraj, R.
Kaur, Manpreet
Jasinski, Jerry P.
Manimekalai, A.
Thiruvalluvar, A.
author_sort Rajkumar, K.
collection PubMed
description The syntheses and crystal structures of 3-(2-chloro­eth­yl)-r-2,c-6-di­phenyl­piperidin-4-one, C(19)H(20)ClNO, (I), and 3-(2-chloro­eth­yl)-r-2,c-6-bis­(4-fluoro­phen­yl)piperidin-4-one, C(19)H(18)ClF(2)NO, (II), are described. The piperidone ring adopts a chair conformation in (I), whereas a slightly distorted chair conformation is formed in (II). The dihedral angle between the mean plane of the phenyl rings is 59.1 (1)° in (I) and 76.1 (1)° in (II). The crystal packing features weak inter­molecular N—H⋯O hydrogen bonds in each structure.
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spelling pubmed-59469732018-05-15 Crystal structures of two new 3-(2-chloro­eth­yl)-r(2),c(6)-diarylpiperidin-4-ones Rajkumar, K. Sivakumar, S. Arulraj, R. Kaur, Manpreet Jasinski, Jerry P. Manimekalai, A. Thiruvalluvar, A. Acta Crystallogr E Crystallogr Commun Research Communications The syntheses and crystal structures of 3-(2-chloro­eth­yl)-r-2,c-6-di­phenyl­piperidin-4-one, C(19)H(20)ClNO, (I), and 3-(2-chloro­eth­yl)-r-2,c-6-bis­(4-fluoro­phen­yl)piperidin-4-one, C(19)H(18)ClF(2)NO, (II), are described. The piperidone ring adopts a chair conformation in (I), whereas a slightly distorted chair conformation is formed in (II). The dihedral angle between the mean plane of the phenyl rings is 59.1 (1)° in (I) and 76.1 (1)° in (II). The crystal packing features weak inter­molecular N—H⋯O hydrogen bonds in each structure. International Union of Crystallography 2018-03-09 /pmc/articles/PMC5946973/ /pubmed/29765751 http://dx.doi.org/10.1107/S2056989018003766 Text en © Rajkumar et al. 2018 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.http://creativecommons.org/licenses/by/2.0/uk/
spellingShingle Research Communications
Rajkumar, K.
Sivakumar, S.
Arulraj, R.
Kaur, Manpreet
Jasinski, Jerry P.
Manimekalai, A.
Thiruvalluvar, A.
Crystal structures of two new 3-(2-chloro­eth­yl)-r(2),c(6)-diarylpiperidin-4-ones
title Crystal structures of two new 3-(2-chloro­eth­yl)-r(2),c(6)-diarylpiperidin-4-ones
title_full Crystal structures of two new 3-(2-chloro­eth­yl)-r(2),c(6)-diarylpiperidin-4-ones
title_fullStr Crystal structures of two new 3-(2-chloro­eth­yl)-r(2),c(6)-diarylpiperidin-4-ones
title_full_unstemmed Crystal structures of two new 3-(2-chloro­eth­yl)-r(2),c(6)-diarylpiperidin-4-ones
title_short Crystal structures of two new 3-(2-chloro­eth­yl)-r(2),c(6)-diarylpiperidin-4-ones
title_sort crystal structures of two new 3-(2-chloro­eth­yl)-r(2),c(6)-diarylpiperidin-4-ones
topic Research Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946973/
https://www.ncbi.nlm.nih.gov/pubmed/29765751
http://dx.doi.org/10.1107/S2056989018003766
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