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Crystal structure and Hirshfeld surface analysis of 4′-(2-chloro­phen­yl)-1′-methyl-3′′-phenyl-7′′,8′′-di­hydro-5′′H-di­spiro­[indoline-3,2′-pyrrolidine-3′,6′′-iso­quinoline]-2,5′′-dione

In the title di­spiro compound, C(32)H(26)ClN(3)O(2), the cyclo­hexa­none ring of the iso­quinoline unit has a distorted envelope conformation, with the methyl­ene C atom adjacent to the spiro C atom as the flap. The central 1-methyl­pyrrolidine ring has an envelope conformation with the N atom as t...

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Detalles Bibliográficos
Autores principales: Vishnupriya, R., Selva Meenatchi, C., Suresh, J., Sumesh, R. V., Kumar, R. Ranjith, Lakshman, P. L. Nilantha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947482/
https://www.ncbi.nlm.nih.gov/pubmed/29850086
http://dx.doi.org/10.1107/S2056989018005455
Descripción
Sumario:In the title di­spiro compound, C(32)H(26)ClN(3)O(2), the cyclo­hexa­none ring of the iso­quinoline unit has a distorted envelope conformation, with the methyl­ene C atom adjacent to the spiro C atom as the flap. The central 1-methyl­pyrrolidine ring has an envelope conformation with the N atom as the flap. The mean planes of the indolin-2-one ring system, the chloro­benzene ring and the iso­quinoline ring system are inclined to the mean plane of the central 1-methyl­pyrrolidine ring by 87.95 (11), 71.01 (12) and 88.81 (10)°, respectively. There are two short C—H⋯O intra­molecular contacts present. In the crystal, mol­ecules are linked via C—H⋯ O hydrogen bonds, forming chains along the a-axis direction. The NH H atom is involved in a weak N—H⋯O hydrogen bond with the same carbonyl O atom. There are no further significant inter­molecular contacts present. The largest contribution to the overall Hirshfeld surface of 52.3% is due to H—H contacts.