Arteriovenous specification: BMPER and TWSG1 determine endothelial cell fate via activation of synergistic BMP and Notch signaling

Two extracellular BMP modulators, BMPER and TWSG1, act in a pro‐BMP fashion to activate endothelial‐specific members of the TGF‐β/BMP receptor family. Through cross‐talk with the Notch signaling pathways, they are key regulators of downstream Notch targets, including ephrin B2. This adds to our unde...

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Detalles Bibliográficos
Autores principales: Osmanagic‐Myers, Selma, Rezniczek, Günther A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947552/
https://www.ncbi.nlm.nih.gov/pubmed/29654706
http://dx.doi.org/10.1111/febs.14439
Descripción
Sumario:Two extracellular BMP modulators, BMPER and TWSG1, act in a pro‐BMP fashion to activate endothelial‐specific members of the TGF‐β/BMP receptor family. Through cross‐talk with the Notch signaling pathways, they are key regulators of downstream Notch targets, including ephrin B2. This adds to our understanding of BMP and Notch signaling, how these pathways converge, and thereby control arteriovenous specification. [Image: see text]

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