Arteriovenous specification: BMPER and TWSG1 determine endothelial cell fate via activation of synergistic BMP and Notch signaling

Two extracellular BMP modulators, BMPER and TWSG1, act in a pro‐BMP fashion to activate endothelial‐specific members of the TGF‐β/BMP receptor family. Through cross‐talk with the Notch signaling pathways, they are key regulators of downstream Notch targets, including ephrin B2. This adds to our unde...

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Detalles Bibliográficos
Autores principales: Osmanagic‐Myers, Selma, Rezniczek, Günther A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947552/
https://www.ncbi.nlm.nih.gov/pubmed/29654706
http://dx.doi.org/10.1111/febs.14439
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author Osmanagic‐Myers, Selma
Rezniczek, Günther A.
author_facet Osmanagic‐Myers, Selma
Rezniczek, Günther A.
author_sort Osmanagic‐Myers, Selma
collection PubMed
description Two extracellular BMP modulators, BMPER and TWSG1, act in a pro‐BMP fashion to activate endothelial‐specific members of the TGF‐β/BMP receptor family. Through cross‐talk with the Notch signaling pathways, they are key regulators of downstream Notch targets, including ephrin B2. This adds to our understanding of BMP and Notch signaling, how these pathways converge, and thereby control arteriovenous specification. [Image: see text]
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spelling pubmed-59475522018-05-17 Arteriovenous specification: BMPER and TWSG1 determine endothelial cell fate via activation of synergistic BMP and Notch signaling Osmanagic‐Myers, Selma Rezniczek, Günther A. FEBS J Commentary Two extracellular BMP modulators, BMPER and TWSG1, act in a pro‐BMP fashion to activate endothelial‐specific members of the TGF‐β/BMP receptor family. Through cross‐talk with the Notch signaling pathways, they are key regulators of downstream Notch targets, including ephrin B2. This adds to our understanding of BMP and Notch signaling, how these pathways converge, and thereby control arteriovenous specification. [Image: see text] John Wiley and Sons Inc. 2018-04-14 2018-04 /pmc/articles/PMC5947552/ /pubmed/29654706 http://dx.doi.org/10.1111/febs.14439 Text en © 2018 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Osmanagic‐Myers, Selma
Rezniczek, Günther A.
Arteriovenous specification: BMPER and TWSG1 determine endothelial cell fate via activation of synergistic BMP and Notch signaling
title Arteriovenous specification: BMPER and TWSG1 determine endothelial cell fate via activation of synergistic BMP and Notch signaling
title_full Arteriovenous specification: BMPER and TWSG1 determine endothelial cell fate via activation of synergistic BMP and Notch signaling
title_fullStr Arteriovenous specification: BMPER and TWSG1 determine endothelial cell fate via activation of synergistic BMP and Notch signaling
title_full_unstemmed Arteriovenous specification: BMPER and TWSG1 determine endothelial cell fate via activation of synergistic BMP and Notch signaling
title_short Arteriovenous specification: BMPER and TWSG1 determine endothelial cell fate via activation of synergistic BMP and Notch signaling
title_sort arteriovenous specification: bmper and twsg1 determine endothelial cell fate via activation of synergistic bmp and notch signaling
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947552/
https://www.ncbi.nlm.nih.gov/pubmed/29654706
http://dx.doi.org/10.1111/febs.14439
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