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A prospective study of fetal head growth, autistic traits and autism spectrum disorder
Altered trajectories of brain growth are often reported in Autism Spectrum Disorder (ASD), particularly during the first year of life. However, less is known about prenatal head growth trajectories, and no study has examined the relation with postnatal autistic symptom severity. The current study pr...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947578/ https://www.ncbi.nlm.nih.gov/pubmed/29356450 http://dx.doi.org/10.1002/aur.1921 |
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author | Blanken, Laura M. E. Dass, Alena Alvares, Gail van der Ende, Jan Schoemaker, Nikita K. El Marroun, Hanan Hickey, Martha Pennell, Craig White, Scott Maybery, Murray T. Dissanayake, Cheryl Jaddoe, Vincent W. V. Verhulst, Frank C. Tiemeier, Henning McIntosh, Will White, Tonya Whitehouse, Andrew |
author_facet | Blanken, Laura M. E. Dass, Alena Alvares, Gail van der Ende, Jan Schoemaker, Nikita K. El Marroun, Hanan Hickey, Martha Pennell, Craig White, Scott Maybery, Murray T. Dissanayake, Cheryl Jaddoe, Vincent W. V. Verhulst, Frank C. Tiemeier, Henning McIntosh, Will White, Tonya Whitehouse, Andrew |
author_sort | Blanken, Laura M. E. |
collection | PubMed |
description | Altered trajectories of brain growth are often reported in Autism Spectrum Disorder (ASD), particularly during the first year of life. However, less is known about prenatal head growth trajectories, and no study has examined the relation with postnatal autistic symptom severity. The current study prospectively examined the association between fetal head growth and the spectrum of autistic symptom severity in two large population‐based cohorts, including a sample of individuals with clinically diagnosed ASD. This study included 3,820 children from two longitudinal prenatal cohorts in The Netherlands and Australia, comprising 60 individuals with a confirmed diagnosis of ASD. Latent growth curve models were used to examine the relationship between fetal head circumference measured at three different time points and autistic traits measured in postnatal life using either the Social Responsiveness Scale or the Autism‐Spectrum Quotient. While lower initial prenatal HC was weakly associated with increasing autistic traits in the Dutch cohort, this relationship was not observed in the Australian cohort, nor when the two cohorts were analysed together. No differences in prenatal head growth were found between individuals with ASD and controls. This large population‐based study identified no consistent association across two cohorts between prenatal head growth and postnatal autistic traits. Our mixed findings suggest that further research in this area is needed. Autism Res 2018, 11: 602–612. © 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. LAY SUMMARY: It is not known whether different patterns of postnatal brain growth in Autism Spectrum Disorder (ASD) also occurs prenatally. We examined fetal head growth and autistic symptoms in two large groups from The Netherlands and Australia. Lower initial prenatal head circumference was associated with autistic traits in the Dutch, but not the Australian, group. No differences in head growth were found in individuals with ASD and controls when the data was combined. Our mixed findings suggest that more research in this area is needed. |
format | Online Article Text |
id | pubmed-5947578 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59475782018-05-17 A prospective study of fetal head growth, autistic traits and autism spectrum disorder Blanken, Laura M. E. Dass, Alena Alvares, Gail van der Ende, Jan Schoemaker, Nikita K. El Marroun, Hanan Hickey, Martha Pennell, Craig White, Scott Maybery, Murray T. Dissanayake, Cheryl Jaddoe, Vincent W. V. Verhulst, Frank C. Tiemeier, Henning McIntosh, Will White, Tonya Whitehouse, Andrew Autism Res Research Articles Altered trajectories of brain growth are often reported in Autism Spectrum Disorder (ASD), particularly during the first year of life. However, less is known about prenatal head growth trajectories, and no study has examined the relation with postnatal autistic symptom severity. The current study prospectively examined the association between fetal head growth and the spectrum of autistic symptom severity in two large population‐based cohorts, including a sample of individuals with clinically diagnosed ASD. This study included 3,820 children from two longitudinal prenatal cohorts in The Netherlands and Australia, comprising 60 individuals with a confirmed diagnosis of ASD. Latent growth curve models were used to examine the relationship between fetal head circumference measured at three different time points and autistic traits measured in postnatal life using either the Social Responsiveness Scale or the Autism‐Spectrum Quotient. While lower initial prenatal HC was weakly associated with increasing autistic traits in the Dutch cohort, this relationship was not observed in the Australian cohort, nor when the two cohorts were analysed together. No differences in prenatal head growth were found between individuals with ASD and controls. This large population‐based study identified no consistent association across two cohorts between prenatal head growth and postnatal autistic traits. Our mixed findings suggest that further research in this area is needed. Autism Res 2018, 11: 602–612. © 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. LAY SUMMARY: It is not known whether different patterns of postnatal brain growth in Autism Spectrum Disorder (ASD) also occurs prenatally. We examined fetal head growth and autistic symptoms in two large groups from The Netherlands and Australia. Lower initial prenatal head circumference was associated with autistic traits in the Dutch, but not the Australian, group. No differences in head growth were found in individuals with ASD and controls when the data was combined. Our mixed findings suggest that more research in this area is needed. John Wiley and Sons Inc. 2018-01-22 2018-04 /pmc/articles/PMC5947578/ /pubmed/29356450 http://dx.doi.org/10.1002/aur.1921 Text en © 2018 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Research Articles Blanken, Laura M. E. Dass, Alena Alvares, Gail van der Ende, Jan Schoemaker, Nikita K. El Marroun, Hanan Hickey, Martha Pennell, Craig White, Scott Maybery, Murray T. Dissanayake, Cheryl Jaddoe, Vincent W. V. Verhulst, Frank C. Tiemeier, Henning McIntosh, Will White, Tonya Whitehouse, Andrew A prospective study of fetal head growth, autistic traits and autism spectrum disorder |
title | A prospective study of fetal head growth, autistic traits and autism spectrum disorder |
title_full | A prospective study of fetal head growth, autistic traits and autism spectrum disorder |
title_fullStr | A prospective study of fetal head growth, autistic traits and autism spectrum disorder |
title_full_unstemmed | A prospective study of fetal head growth, autistic traits and autism spectrum disorder |
title_short | A prospective study of fetal head growth, autistic traits and autism spectrum disorder |
title_sort | prospective study of fetal head growth, autistic traits and autism spectrum disorder |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947578/ https://www.ncbi.nlm.nih.gov/pubmed/29356450 http://dx.doi.org/10.1002/aur.1921 |
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