A horizontally gene transferred copper resistance locus confers hyper‐resistance to antibacterial copper toxicity and enables survival of community acquired methicillin resistant Staphylococcus aureus USA300 in macrophages

Excess copper is highly toxic and forms part of the host innate immune system's antibacterial arsenal, accumulating at sites of infection and acting within macrophages to kill engulfed pathogens. We show for the first time that a novel, horizontally gene transferred copper resistance locus (cop...

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Detalles Bibliográficos
Autores principales: Purves, Joanne, Thomas, Jamie, Riboldi, Gustavo P., Zapotoczna, Marta, Tarrant, Emma, Andrew, Peter W., Londoño, Alejandra, Planet, Paul J., Geoghegan, Joan A., Waldron, Kevin J., Morrissey, Julie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947656/
https://www.ncbi.nlm.nih.gov/pubmed/29521441
http://dx.doi.org/10.1111/1462-2920.14088

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