Crystal structures of sampatrilat and sampatrilat‐Asp in complex with human ACE – a molecular basis for domain selectivity

Angiotensin‐1‐converting enzyme (ACE) is a zinc metallopeptidase that consists of two homologous catalytic domains (known as nACE and cACE) with different substrate specificities. Based on kinetic studies it was previously reported that sampatrilat, a tight‐binding inhibitor of ACE, K (i) = 13.8 nm...

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Detalles Bibliográficos
Autores principales: Cozier, Gyles E., Schwager, Sylva L., Sharma, Rajni K., Chibale, Kelly, Sturrock, Edward D., Acharya, K. Ravi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947662/
https://www.ncbi.nlm.nih.gov/pubmed/29476645
http://dx.doi.org/10.1111/febs.14421

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947662/
https://www.ncbi.nlm.nih.gov/pubmed/29476645
http://dx.doi.org/10.1111/febs.14421

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