Cloning, purification and structure determination of the HIV integrase-binding domain of lens epithelium-derived growth factor

Lens epithelium-derived growth factor (LEDGF)/p75 is the dominant binding partner of HIV-1 integrase in human cells. The crystal structure of the HIV integrase-binding domain (IBD) of LEDGF has been determined in the absence of ligand. IBD was overexpressed in Escherichia coli, purified and crystall...

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Detalles Bibliográficos
Autores principales: Hannon, Clare, Cruz-Migoni, Abimael, Platonova, Olga, Owen, Robin L., Nettleship, Joanne E., Miller, Ami, Carr, Stephen B., Harris, Gemma, Rabbitts, Terence H., Phillips, Simon E. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2018
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947699/
https://www.ncbi.nlm.nih.gov/pubmed/29497017
http://dx.doi.org/10.1107/S2053230X18001553

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