AutoCSA, an algorithm for high throughput DNA sequence variant detection in cancer genomes

The undertaking of large-scale DNA sequencing screens for somatic variants in human cancers requires accurate and rapid processing of traces for variants. Due to their often aneuploid nature and admixed normal tissue, heterozygous variants found in primary cancers are often subtle and difficult to d...

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Autores principales: Dicks, E., Teague, J. W., Stephens, P., Raine, K., Yates, A., Mattocks, C., Tarpey, P., Butler, A., Menzies, A., Richardson, D., Jenkinson, A., Davies, H., Edkins, S., Forbes, S., Gray, K., Greenman, C., Shepherd, R., Stratton, M. R., Futreal, P. A., Wooster, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2007
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947781/
https://www.ncbi.nlm.nih.gov/pubmed/17485433
http://dx.doi.org/10.1093/bioinformatics/btm152
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author Dicks, E.
Teague, J. W.
Stephens, P.
Raine, K.
Yates, A.
Mattocks, C.
Tarpey, P.
Butler, A.
Menzies, A.
Richardson, D.
Jenkinson, A.
Davies, H.
Edkins, S.
Forbes, S.
Gray, K.
Greenman, C.
Shepherd, R.
Stratton, M. R.
Futreal, P. A.
Wooster, R.
author_facet Dicks, E.
Teague, J. W.
Stephens, P.
Raine, K.
Yates, A.
Mattocks, C.
Tarpey, P.
Butler, A.
Menzies, A.
Richardson, D.
Jenkinson, A.
Davies, H.
Edkins, S.
Forbes, S.
Gray, K.
Greenman, C.
Shepherd, R.
Stratton, M. R.
Futreal, P. A.
Wooster, R.
author_sort Dicks, E.
collection PubMed
description The undertaking of large-scale DNA sequencing screens for somatic variants in human cancers requires accurate and rapid processing of traces for variants. Due to their often aneuploid nature and admixed normal tissue, heterozygous variants found in primary cancers are often subtle and difficult to detect. To address these issues, we have developed a mutation detection algorithm, AutoCSA, specifically optimized for the high throughput screening of cancer samples.
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spelling pubmed-59477812018-05-11 AutoCSA, an algorithm for high throughput DNA sequence variant detection in cancer genomes Dicks, E. Teague, J. W. Stephens, P. Raine, K. Yates, A. Mattocks, C. Tarpey, P. Butler, A. Menzies, A. Richardson, D. Jenkinson, A. Davies, H. Edkins, S. Forbes, S. Gray, K. Greenman, C. Shepherd, R. Stratton, M. R. Futreal, P. A. Wooster, R. Bioinformatics Article The undertaking of large-scale DNA sequencing screens for somatic variants in human cancers requires accurate and rapid processing of traces for variants. Due to their often aneuploid nature and admixed normal tissue, heterozygous variants found in primary cancers are often subtle and difficult to detect. To address these issues, we have developed a mutation detection algorithm, AutoCSA, specifically optimized for the high throughput screening of cancer samples. 2007-05-07 2007-07-01 /pmc/articles/PMC5947781/ /pubmed/17485433 http://dx.doi.org/10.1093/bioinformatics/btm152 Text en http://creativecommons.org/licenses/by-nc/2.0/uk/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Dicks, E.
Teague, J. W.
Stephens, P.
Raine, K.
Yates, A.
Mattocks, C.
Tarpey, P.
Butler, A.
Menzies, A.
Richardson, D.
Jenkinson, A.
Davies, H.
Edkins, S.
Forbes, S.
Gray, K.
Greenman, C.
Shepherd, R.
Stratton, M. R.
Futreal, P. A.
Wooster, R.
AutoCSA, an algorithm for high throughput DNA sequence variant detection in cancer genomes
title AutoCSA, an algorithm for high throughput DNA sequence variant detection in cancer genomes
title_full AutoCSA, an algorithm for high throughput DNA sequence variant detection in cancer genomes
title_fullStr AutoCSA, an algorithm for high throughput DNA sequence variant detection in cancer genomes
title_full_unstemmed AutoCSA, an algorithm for high throughput DNA sequence variant detection in cancer genomes
title_short AutoCSA, an algorithm for high throughput DNA sequence variant detection in cancer genomes
title_sort autocsa, an algorithm for high throughput dna sequence variant detection in cancer genomes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947781/
https://www.ncbi.nlm.nih.gov/pubmed/17485433
http://dx.doi.org/10.1093/bioinformatics/btm152
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