Cargando…
The role of phospholipid molecular species in determining the physical properties of yeast membranes
In most eukaryotes, including Saccharomyces cerevisiae, glycerophospholipids are the main membrane lipid constituents. Besides serving as general membrane ‘building blocks’, glycerophospholipids play an important role in determining the physical properties of the membrane, which are crucial for prop...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947837/ https://www.ncbi.nlm.nih.gov/pubmed/29265372 http://dx.doi.org/10.1002/1873-3468.12944 |
_version_ | 1783322451101351936 |
---|---|
author | Renne, Mike F. de Kroon, Anton I. P. M. |
author_facet | Renne, Mike F. de Kroon, Anton I. P. M. |
author_sort | Renne, Mike F. |
collection | PubMed |
description | In most eukaryotes, including Saccharomyces cerevisiae, glycerophospholipids are the main membrane lipid constituents. Besides serving as general membrane ‘building blocks’, glycerophospholipids play an important role in determining the physical properties of the membrane, which are crucial for proper membrane function. To ensure optimal physical properties, membrane glycerophospholipid composition and synthesis are tightly regulated. This review will summarize our current knowledge of factors and processes determining the membrane glycerophospholipid composition of the reference eukaryote S. cerevisiae at the level of molecular species. Extrapolating from relevant model membrane data, we also discuss how modulation of the molecular species composition can regulate membrane physical properties. |
format | Online Article Text |
id | pubmed-5947837 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59478372018-05-17 The role of phospholipid molecular species in determining the physical properties of yeast membranes Renne, Mike F. de Kroon, Anton I. P. M. FEBS Lett Review Articles In most eukaryotes, including Saccharomyces cerevisiae, glycerophospholipids are the main membrane lipid constituents. Besides serving as general membrane ‘building blocks’, glycerophospholipids play an important role in determining the physical properties of the membrane, which are crucial for proper membrane function. To ensure optimal physical properties, membrane glycerophospholipid composition and synthesis are tightly regulated. This review will summarize our current knowledge of factors and processes determining the membrane glycerophospholipid composition of the reference eukaryote S. cerevisiae at the level of molecular species. Extrapolating from relevant model membrane data, we also discuss how modulation of the molecular species composition can regulate membrane physical properties. John Wiley and Sons Inc. 2017-12-29 2018-04 /pmc/articles/PMC5947837/ /pubmed/29265372 http://dx.doi.org/10.1002/1873-3468.12944 Text en © 2017 The Authors. FEBS Letters published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Articles Renne, Mike F. de Kroon, Anton I. P. M. The role of phospholipid molecular species in determining the physical properties of yeast membranes |
title | The role of phospholipid molecular species in determining the physical properties of yeast membranes |
title_full | The role of phospholipid molecular species in determining the physical properties of yeast membranes |
title_fullStr | The role of phospholipid molecular species in determining the physical properties of yeast membranes |
title_full_unstemmed | The role of phospholipid molecular species in determining the physical properties of yeast membranes |
title_short | The role of phospholipid molecular species in determining the physical properties of yeast membranes |
title_sort | role of phospholipid molecular species in determining the physical properties of yeast membranes |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5947837/ https://www.ncbi.nlm.nih.gov/pubmed/29265372 http://dx.doi.org/10.1002/1873-3468.12944 |
work_keys_str_mv | AT rennemikef theroleofphospholipidmolecularspeciesindeterminingthephysicalpropertiesofyeastmembranes AT dekroonantonipm theroleofphospholipidmolecularspeciesindeterminingthephysicalpropertiesofyeastmembranes AT rennemikef roleofphospholipidmolecularspeciesindeterminingthephysicalpropertiesofyeastmembranes AT dekroonantonipm roleofphospholipidmolecularspeciesindeterminingthephysicalpropertiesofyeastmembranes |