Interaction between STAT3 and GLI1/tGLI1 oncogenic transcription factors promotes the aggressiveness of triple-negative and HER2-enriched breast cancers

STAT3, GLI1, and truncated GLI1 (tGLI1) are oncogenic transcription factors playing important roles in breast cancer. tGLI1 is a gain-of-function GLI1 isoform. Whether STAT3 physically and/or functionally interacts with GLI1/tGLI1 has not been explored. To address this knowledge gap, we analyzed 47...

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Detalles Bibliográficos
Autores principales: Sirkisoon, Sherona R., Carpenter, Richard L., Rimkus, Tadas, Anderson, Ashley, Harrison, Alexandria, Lange, Allison M., Jin, Guangxu, Watabe, Kounosuke, Lo, Hui-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948110/
https://www.ncbi.nlm.nih.gov/pubmed/29449694
http://dx.doi.org/10.1038/s41388-018-0132-4

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