Bilateral Mastectomy as Radical Treatment of Gynecomastia Secondary to Antiretroviral Therapy in a Low-Income Setting: A Case Report

Gynecomastia is a common finding in males, with an incidence that varies widely globally. In 10–25% of cases, it is caused by drugs. Its pathophysiologic mechanism includes exposure to exogenous estrogens and medications that cause hypogonadism, antiandrogenic effects and hyperprolactinemia. Gynecom...

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Detalles Bibliográficos
Autores principales: Antunes, Mario, Schiavone, Marcella, Pizzol, Damiano, Di Gennaro, Francesco, Ludovico, Rossana, De Palma, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948190/
https://www.ncbi.nlm.nih.gov/pubmed/29752634
http://dx.doi.org/10.1007/s40800-018-0085-0
Descripción
Sumario:Gynecomastia is a common finding in males, with an incidence that varies widely globally. In 10–25% of cases, it is caused by drugs. Its pathophysiologic mechanism includes exposure to exogenous estrogens and medications that cause hypogonadism, antiandrogenic effects and hyperprolactinemia. Gynecomastia is associated with exposure to antiretroviral therapy (ART), particularly efavirenz. Sometimes surgery may be required as treatment. We report a case of a 46-year-old man receiving ART presenting with a marked bilateral breast enlargement who underwent bilateral mastectomy as the only successful treatment in a low-income setting.

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