Adeno-associated Virus Genome Population Sequencing Achieves Full Vector Genome Resolution and Reveals Human-Vector Chimeras

Recombinant adeno-associated virus (rAAV)-based gene therapy has entered a phase of clinical translation and commercialization. Despite this progress, vector integrity following production is often overlooked. Compromised vectors may negatively impact therapeutic efficacy and safety. Using single mo...

Descripción completa

Detalles Bibliográficos
Autores principales: Tai, Phillip W.L., Xie, Jun, Fong, Kaiyuen, Seetin, Matthew, Heiner, Cheryl, Su, Qin, Weiand, Michael, Wilmot, Daniella, Zapp, Maria L., Gao, Guangping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948225/
https://www.ncbi.nlm.nih.gov/pubmed/29766023
http://dx.doi.org/10.1016/j.omtm.2018.02.002

Ejemplares similares

Ejemplares similares