Serum-free Erythroid Differentiation for Efficient Genetic Modification and High-Level Adult Hemoglobin Production

In vitro erythroid differentiation from primary human cells is valuable to develop genetic strategies for hemoglobin disorders. However, current erythroid differentiation methods are encumbered by modest transduction rates and high baseline fetal hemoglobin production. In this study, we sought to im...

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Detalles Bibliográficos
Autores principales: Uchida, Naoya, Demirci, Selami, Haro-Mora, Juan J., Fujita, Atsushi, Raines, Lydia N., Hsieh, Matthew M., Tisdale, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948232/
https://www.ncbi.nlm.nih.gov/pubmed/29766032
http://dx.doi.org/10.1016/j.omtm.2018.03.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948232/
https://www.ncbi.nlm.nih.gov/pubmed/29766032
http://dx.doi.org/10.1016/j.omtm.2018.03.007

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