Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity

Poly(ADP-ribose) polymerases (PARPs) and sirtuins (SIRTs) are involved in the regulation of cell metabolism, transcription, and DNA repair. Alterations of these enzymes may play a crucial role in Alzheimer’s disease (AD). Our previous results indicated that amyloid beta (Aβ) peptides and inflammatio...

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Detalles Bibliográficos
Autores principales: Wencel, Przemysław L., Lukiw, Walter J., Strosznajder, Joanna B., Strosznajder, Robert Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948241/
https://www.ncbi.nlm.nih.gov/pubmed/28698968
http://dx.doi.org/10.1007/s12035-017-0646-8

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