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Therapeutic potential of GSK-J4, a histone demethylase KDM6B/JMJD3 inhibitor, for acute myeloid leukemia

PURPOSE: Acute myeloid leukemia (AML) is a heterogeneous disease with poor outcomes. Despite increased evidence shows that dysregulation of histone modification contributes to AML, specific drugs targeting key histone modulators are not applied in the clinical treatment of AML. Here, we investigated...

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Detalles Bibliográficos
Autores principales:	Li, Yunan, Zhang, Mingying, Sheng, Mengyao, Zhang, Peng, Chen, Zizhen, Xing, Wen, Bai, Jie, Cheng, Tao, Yang, Feng-Chun, Zhou, Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2018
Materias:	Original Article – Cancer Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948279/ https://www.ncbi.nlm.nih.gov/pubmed/29594337 http://dx.doi.org/10.1007/s00432-018-2631-7

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