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A Novel “Off-On” Fluorescent Probe Based on Carbon Nitride Nanoribbons for the Detection of Citrate Anion and Live Cell Imaging
A novel fluorescent “off-on” probe based on carbon nitride (C(3)N(4)) nanoribbons was developed for citrate anion (C(6)H(5)O(7)(3−)) detection. The fluorescence of C(3)N(4) nanoribbons can be quenched by Cu(2+) and then recovered by the addition of C(6)H(5)O(7)(3−), because the chelation between C(6...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948658/ https://www.ncbi.nlm.nih.gov/pubmed/29641452 http://dx.doi.org/10.3390/s18041163 |
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author | Hu, Yanling Yang, Dongliang Yang, Chen Feng, Ning Shao, Zhouwei Zhang, Lei Wang, Xiaodong Weng, Lixing Luo, Zhimin Wang, Lianhui |
author_facet | Hu, Yanling Yang, Dongliang Yang, Chen Feng, Ning Shao, Zhouwei Zhang, Lei Wang, Xiaodong Weng, Lixing Luo, Zhimin Wang, Lianhui |
author_sort | Hu, Yanling |
collection | PubMed |
description | A novel fluorescent “off-on” probe based on carbon nitride (C(3)N(4)) nanoribbons was developed for citrate anion (C(6)H(5)O(7)(3−)) detection. The fluorescence of C(3)N(4) nanoribbons can be quenched by Cu(2+) and then recovered by the addition of C(6)H(5)O(7)(3−), because the chelation between C(6)H(5)O(7)(3−) and Cu(2+) blocks the electron transfer between Cu(2+) and C(3)N(4) nanoribbons. The turn-on fluorescent sensor using this fluorescent “off-on” probe can detect C(6)H(5)O(7)(3−) rapidly and selectively, showing a wide detection linear range (1~400 μM) and a low detection limit (0.78 μM) in aqueous solutions. Importantly, this C(3)N(4) nanoribbon-based “off-on” probe exhibits good biocompatibility and can be used as fluorescent visualizer for exogenous C(6)H(5)O(7)(3−) in HeLa cells. |
format | Online Article Text |
id | pubmed-5948658 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-59486582018-05-17 A Novel “Off-On” Fluorescent Probe Based on Carbon Nitride Nanoribbons for the Detection of Citrate Anion and Live Cell Imaging Hu, Yanling Yang, Dongliang Yang, Chen Feng, Ning Shao, Zhouwei Zhang, Lei Wang, Xiaodong Weng, Lixing Luo, Zhimin Wang, Lianhui Sensors (Basel) Article A novel fluorescent “off-on” probe based on carbon nitride (C(3)N(4)) nanoribbons was developed for citrate anion (C(6)H(5)O(7)(3−)) detection. The fluorescence of C(3)N(4) nanoribbons can be quenched by Cu(2+) and then recovered by the addition of C(6)H(5)O(7)(3−), because the chelation between C(6)H(5)O(7)(3−) and Cu(2+) blocks the electron transfer between Cu(2+) and C(3)N(4) nanoribbons. The turn-on fluorescent sensor using this fluorescent “off-on” probe can detect C(6)H(5)O(7)(3−) rapidly and selectively, showing a wide detection linear range (1~400 μM) and a low detection limit (0.78 μM) in aqueous solutions. Importantly, this C(3)N(4) nanoribbon-based “off-on” probe exhibits good biocompatibility and can be used as fluorescent visualizer for exogenous C(6)H(5)O(7)(3−) in HeLa cells. MDPI 2018-04-11 /pmc/articles/PMC5948658/ /pubmed/29641452 http://dx.doi.org/10.3390/s18041163 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hu, Yanling Yang, Dongliang Yang, Chen Feng, Ning Shao, Zhouwei Zhang, Lei Wang, Xiaodong Weng, Lixing Luo, Zhimin Wang, Lianhui A Novel “Off-On” Fluorescent Probe Based on Carbon Nitride Nanoribbons for the Detection of Citrate Anion and Live Cell Imaging |
title | A Novel “Off-On” Fluorescent Probe Based on Carbon Nitride Nanoribbons for the Detection of Citrate Anion and Live Cell Imaging |
title_full | A Novel “Off-On” Fluorescent Probe Based on Carbon Nitride Nanoribbons for the Detection of Citrate Anion and Live Cell Imaging |
title_fullStr | A Novel “Off-On” Fluorescent Probe Based on Carbon Nitride Nanoribbons for the Detection of Citrate Anion and Live Cell Imaging |
title_full_unstemmed | A Novel “Off-On” Fluorescent Probe Based on Carbon Nitride Nanoribbons for the Detection of Citrate Anion and Live Cell Imaging |
title_short | A Novel “Off-On” Fluorescent Probe Based on Carbon Nitride Nanoribbons for the Detection of Citrate Anion and Live Cell Imaging |
title_sort | novel “off-on” fluorescent probe based on carbon nitride nanoribbons for the detection of citrate anion and live cell imaging |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948658/ https://www.ncbi.nlm.nih.gov/pubmed/29641452 http://dx.doi.org/10.3390/s18041163 |
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