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PSMA-PET based radiotherapy: a review of initial experiences, survey on current practice and future perspectives

(68)Gallium prostate specific membrane antigen (PSMA) ligand positron emission tomography (PET) is an increasingly used imaging modality in prostate cancer, especially in cases of tumor recurrence after curative intended therapy. Owed to the novelty of the PSMA-targeting tracers, clinical evidence o...

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Detalles Bibliográficos
Autores principales: Zschaeck, Sebastian, Lohaus, Fabian, Beck, Marcus, Habl, Gregor, Kroeze, Stephanie, Zamboglou, Constantinos, Koerber, Stefan Alexander, Debus, Jürgen, Hölscher, Tobias, Wust, Peter, Ganswindt, Ute, Baur, Alexander D. J., Zöphel, Klaus, Cihoric, Nikola, Guckenberger, Matthias, Combs, Stephanie E., Grosu, Anca Ligia, Ghadjar, Pirus, Belka, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948793/
https://www.ncbi.nlm.nih.gov/pubmed/29751842
http://dx.doi.org/10.1186/s13014-018-1047-5
Descripción
Sumario:(68)Gallium prostate specific membrane antigen (PSMA) ligand positron emission tomography (PET) is an increasingly used imaging modality in prostate cancer, especially in cases of tumor recurrence after curative intended therapy. Owed to the novelty of the PSMA-targeting tracers, clinical evidence on the value of PSMA-PET is moderate but rapidly increasing. State of the art imaging is pivotal for radiotherapy treatment planning as it may affect dose prescription, target delineation and use of concomitant therapy. This review summarizes the evidence on PSMA-PET imaging from a radiation oncologist’s point of view. Additionally a short survey containing twelve examples of patients and 6 additional questions was performed in seven mayor academic centers with experience in PSMA ligand imaging and the findings are reported here. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13014-018-1047-5) contains supplementary material, which is available to authorized users.