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Inhibition of glutamate oxaloacetate transaminase 1 in cancer cell lines results in altered metabolism with increased dependency of glucose

BACKGROUND: Glutamate oxaloacetate transaminase 1 (GOT1) regulates cellular metabolism through coordinating the utilization of carbohydrates and amino acids to meet nutrient requirements. KRAS mutated cancer cells were recently shown to rely on GOT1 to support long-term cell proliferation. The aim o...

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Detalles Bibliográficos
Autores principales:	Zhou, Xiaoshan, Curbo, Sophie, Li, Fuqiang, Krishnan, Shuba, Karlsson, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948873/ https://www.ncbi.nlm.nih.gov/pubmed/29751795 http://dx.doi.org/10.1186/s12885-018-4443-1

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