QuantiFERON-TB Gold In-tube test for the diagnosis of active and latent tuberculosis in selected health facilities of Addis Ababa, Ethiopia

OBJECTIVE: To determine the performance of QuantiFERON-TB IN-Gold for the diagnosis active tuberculosis and latent tuberculosis. RESULTS: A total of 213 participants (136 tuberculosis suspects, 66 latently infected) were enrolled. Of 213, 21 (15.4%) of the tuberculosis suspects and 3 (4.5%) of the l...

Descripción completa

Detalles Bibliográficos
Autores principales: Niguse, Selam, Desta, Kassu, Gebremichael, Gebremdihin, Gebrezgeaxier, Atsebeha, Getahun, Mulluwork, Kassa, Desta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948922/
https://www.ncbi.nlm.nih.gov/pubmed/29751780
http://dx.doi.org/10.1186/s13104-018-3410-x
_version_ 1783322661708890112
author Niguse, Selam
Desta, Kassu
Gebremichael, Gebremdihin
Gebrezgeaxier, Atsebeha
Getahun, Mulluwork
Kassa, Desta
author_facet Niguse, Selam
Desta, Kassu
Gebremichael, Gebremdihin
Gebrezgeaxier, Atsebeha
Getahun, Mulluwork
Kassa, Desta
author_sort Niguse, Selam
collection PubMed
description OBJECTIVE: To determine the performance of QuantiFERON-TB IN-Gold for the diagnosis active tuberculosis and latent tuberculosis. RESULTS: A total of 213 participants (136 tuberculosis suspects, 66 latently infected) were enrolled. Of 213, 21 (15.4%) of the tuberculosis suspects and 3 (4.5%) of the latent tuberculosis groups were human immunodeficiency virus infected. The sensitivity, specificity, positive and negative predictive value of QuantiFERON-TB IN-Gold for the diagnosis of active tuberculosis was 70.3% (26/37), 49.5% (49/99), 34.7% (26/75) and 83.1% (49/59) respectively. A kappa value of 0.316 (p = 0.001, 95% CI 1.605–1.609) between QuantiFERON-TB IN-Gold and tuberculin skin test were found.
format Online
Article
Text
id pubmed-5948922
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-59489222018-05-18 QuantiFERON-TB Gold In-tube test for the diagnosis of active and latent tuberculosis in selected health facilities of Addis Ababa, Ethiopia Niguse, Selam Desta, Kassu Gebremichael, Gebremdihin Gebrezgeaxier, Atsebeha Getahun, Mulluwork Kassa, Desta BMC Res Notes Research Note OBJECTIVE: To determine the performance of QuantiFERON-TB IN-Gold for the diagnosis active tuberculosis and latent tuberculosis. RESULTS: A total of 213 participants (136 tuberculosis suspects, 66 latently infected) were enrolled. Of 213, 21 (15.4%) of the tuberculosis suspects and 3 (4.5%) of the latent tuberculosis groups were human immunodeficiency virus infected. The sensitivity, specificity, positive and negative predictive value of QuantiFERON-TB IN-Gold for the diagnosis of active tuberculosis was 70.3% (26/37), 49.5% (49/99), 34.7% (26/75) and 83.1% (49/59) respectively. A kappa value of 0.316 (p = 0.001, 95% CI 1.605–1.609) between QuantiFERON-TB IN-Gold and tuberculin skin test were found. BioMed Central 2018-05-11 /pmc/articles/PMC5948922/ /pubmed/29751780 http://dx.doi.org/10.1186/s13104-018-3410-x Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Note
Niguse, Selam
Desta, Kassu
Gebremichael, Gebremdihin
Gebrezgeaxier, Atsebeha
Getahun, Mulluwork
Kassa, Desta
QuantiFERON-TB Gold In-tube test for the diagnosis of active and latent tuberculosis in selected health facilities of Addis Ababa, Ethiopia
title QuantiFERON-TB Gold In-tube test for the diagnosis of active and latent tuberculosis in selected health facilities of Addis Ababa, Ethiopia
title_full QuantiFERON-TB Gold In-tube test for the diagnosis of active and latent tuberculosis in selected health facilities of Addis Ababa, Ethiopia
title_fullStr QuantiFERON-TB Gold In-tube test for the diagnosis of active and latent tuberculosis in selected health facilities of Addis Ababa, Ethiopia
title_full_unstemmed QuantiFERON-TB Gold In-tube test for the diagnosis of active and latent tuberculosis in selected health facilities of Addis Ababa, Ethiopia
title_short QuantiFERON-TB Gold In-tube test for the diagnosis of active and latent tuberculosis in selected health facilities of Addis Ababa, Ethiopia
title_sort quantiferon-tb gold in-tube test for the diagnosis of active and latent tuberculosis in selected health facilities of addis ababa, ethiopia
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5948922/
https://www.ncbi.nlm.nih.gov/pubmed/29751780
http://dx.doi.org/10.1186/s13104-018-3410-x
work_keys_str_mv AT niguseselam quantiferontbgoldintubetestforthediagnosisofactiveandlatenttuberculosisinselectedhealthfacilitiesofaddisababaethiopia
AT destakassu quantiferontbgoldintubetestforthediagnosisofactiveandlatenttuberculosisinselectedhealthfacilitiesofaddisababaethiopia
AT gebremichaelgebremdihin quantiferontbgoldintubetestforthediagnosisofactiveandlatenttuberculosisinselectedhealthfacilitiesofaddisababaethiopia
AT gebrezgeaxieratsebeha quantiferontbgoldintubetestforthediagnosisofactiveandlatenttuberculosisinselectedhealthfacilitiesofaddisababaethiopia
AT getahunmulluwork quantiferontbgoldintubetestforthediagnosisofactiveandlatenttuberculosisinselectedhealthfacilitiesofaddisababaethiopia
AT kassadesta quantiferontbgoldintubetestforthediagnosisofactiveandlatenttuberculosisinselectedhealthfacilitiesofaddisababaethiopia

Ejemplares similares